bis(2-hydroxyethyl)ammonium salicylate | 109962-24-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(2-hydroxyethyl)ammonium salicylate
• 英文别名: bis(2-hydroxy-ethyl)ammonium 2-hydroxy-benzoate；2-Hydroxybenzoic acid;2-(2-hydroxyethylamino)ethanol
• CAS: 109962-24-5
• 化学式: C₄H₁₁NO₂*C₇H₆O₃
• 分子量: 243.26
• InChiKey: CZGCKCNJZSEAQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.01
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  117
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  二乙醇胺 、 阿司匹林 在 甲醇 作用下， 反应 1.0h， 以96%的产率得到bis(2-hydroxyethyl)ammonium salicylate
  参考文献：
  名称：

  Biologically active protic (2-hydroxyethyl)ammonium ionic liquids. Liquid aspirin

  摘要：

  DOI：

  10.1007/s11172-012-0172-9

文献信息

• Synthesis of novel non-toxic naphthenic and benzoic acid ionic liquids. Structure-properties relationship and evaluation of their biodegradability potential
  作者：Andromachi Tzani、Dimitrios Skarpalezos、Achilleas Papadopoulos、Dionysia Aravopoulou、Ioannis Kleidas、Efstathia Ioannou、Epaminondas Voutsas、Apostolos Kyritsis、Anastasia Detsi

  DOI：10.1016/j.molliq.2019.111927

  日期：2019.12

  alternatives to common organic solvents but in order to efficiently be characterized as green their environmental impact has to be assessed. In the present study, the design, synthesis and an initial potential hazard assessment of 11 naphthenic and benzoic acid based PILs is presented. PILs’ “greenness” is enhanced considering that they are non-toxic according to the aquatic toxicity evaluation and most

  质子离子液体（PIL）是有前途的溶剂，具有各种应用所需的理化特性。它们被认为是普通有机溶剂的更绿色替代品，但是为了有效地将其表征为绿色，必须评估其对环境的影响。在本研究中，提出了基于11种环烷酸和苯甲酸的PIL的设计，合成和初步潜在危害评估。根据水生毒性评估，PIL的“绿色”得到了增强，因为它们无毒，而且大多数都令人满意地显示出极高的生物降解水平。此外，它们最重要的两个物理化学特性是粘度和玻璃化转变温度（T g确定所选IL的）。为了研究环境和物理化学性质，还讨论了芳香族和脂环族对阴离子，阴离子和阳离子上羟基取代基的大小和存在的影响。
• Diethanolammonium protic ionic liquids - promising buffers for the synthesis of 68Ga- labelled radiopharmaceuticals
  作者：Yulia A. Kondratenko、Dmitrii O. Antuganov、Andrey A. Zolotarev、Michail A. Nadporojskii、Valery L. Ugolkov、Tatyana A. Kochina

  DOI：10.1016/j.molliq.2021.117029

  日期：2022.1

  diethanolammonium (DEA) salts of carboxylic acids have been synthesized and identified using a complex of physicochemical methods (NMR, FT-IR spectroscopy, elemental, thermal analysis). The crystal structure of diethanolammonium salts of benzoic and 2-hydroxy-1-naphthoic acids was determined for the first time by XRD. A comparative analysis of the conformations of DEA cations was carried out. The effectiveness

  已经合成并使用一系列物理化学方法（NMR、FT-IR 光谱、元素、热分析）鉴定了 15 种基于羧酸的二乙醇铵 (DEA) 盐的新型质子离子液体。通过XRD首次确定了苯甲酸和2-羟基-1-萘甲酸的二乙醇铵盐的晶体结构。对 DEA 阳离子的构象进行了比较分析。合成的 DEA 离子液体作为缓冲剂的有效性在68 次Ga 放射性标记反应中与不同的螯合剂和临床批准的肽进行了证明。
• Ionic Liquids
  申请人：Walker Adam John

  公开号：US20080221361A1

  公开（公告）日：2008-09-11

  The invention provides ionic liquids and processes for their preparation. The liquids may either comprise a cation of the formula (I); N + HR 1 R 2 R 3 (I) wherein R 1 is a group —R 4 —O—R 5 ; R 2 and R 3 are each independently either hydrogen or hydrocarbyl, R 2 and R 3 may be joined together with the N to form a heterocyclic group; R 4 is a divalent hydrocarbyl radical; and R 5 is hydrocarbyl; or a cation of the formula (II), N+HR6R7R8 (II) wherein R 6 is an alkanolyl group; R 7 is a hydrocarbyl group; and R 8 is either hydrogen or hydrocarbyl, or R 7 and R 8 may be joined together with the N to form a heterocyclic group.

  本发明提供了离子液体及其制备方法。这些液体可以包括公式（I）的阳离子; N+HR1R2R3（I），其中R1是一个基团-R4-O-R5; R2和R3分别是氢或烃基，R2和R3可以与N结合形成杂环基团; R4是一个二价的烃基基团; R5是烃基; 或者是公式（II）的阳离子，N+HR6R7R8（II），其中R6是烷基醇基团; R7是烃基基团; R8是氢或烃基，或者R7和R8可以与N结合形成杂环基团。
• Ionic liquids comprising nitrogen containing cations
  申请人：Innovia Films Limited

  公开号：EP2322497A1

  公开（公告）日：2011-05-18

  The present invention relates to ionic liquid comprising an anion and a cation wherein the cation is a primary, secondary or tertiary ammonium ion containing a protonated nitrogen atom.

  本发明涉及由阴离子和阳离子组成的离子液体，其中阳离子是含有质子化氮原子的一级、二级或三级铵离子。
• Composition for film formation, method of film formation, and silica-based film
  申请人：JSR CORPORATION

  公开号：US20030091838A1

  公开（公告）日：2003-05-15

  A composition for film formation which comprises: (A) a product of hydrolysis and condensation obtained by hydrolyzing and condensing at least one silane compound selected from the group consisting of compounds represented by the formula (1), compounds represented by the formula (2), and compounds represented by the formula (3) in the presence of water and an ammonium compound, and (B) an organic solvent.

  一种用于成膜的组合物，它包括 (A) 至少一种硅烷化合物的水解和缩合产物，该硅烷化合物选自由式（1）、式（2）和式（3）所代表的化合物组成的组，在水和铵化合物存在下水解和缩合得到，以及 (B) 有机溶剂。