1-phenyl-N¹,N²-ditosylethane-1,2-diamine | 35550-12-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-phenyl-N¹,N²-ditosylethane-1,2-diamine
• 英文别名: 1,2-Bis--1-phenyl-ethan；N,N'-Di-(p-tolylsulfonyl)-1-phenyl-1,2-ethylendiamin；N,N'-Di(p-toluenesulfonyl)-1,2-diamino-1-phenylethane；4-methyl-N-[2-[(4-methylphenyl)sulfonylamino]-2-phenylethyl]benzenesulfonamide
• CAS: 35550-12-0
• 化学式: C₂₂H₂₄N₂O₄S₂
• 分子量: 444.576
• InChiKey: HOIVORUOLGPEAX-UHFFFAOYSA-N

物化性质

• 沸点：
  635.7±65.0 °C(Predicted)
• 密度：
  1.286±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  chloroamine-T 在 tin(II) iodide 作用下， 以 乙腈 为溶剂， 反应 88.0h， 生成 1-phenyl-N¹,N²-ditosylethane-1,2-diamine
  参考文献：
  名称：

  Tin(II) Iodide-catalyzed Selective Aziri- dination or 1,2-Diamination of Alkenes with Chloramine-T

  摘要：

  Tin(II) iodide selectively catalyzes reactions of alkenes in acetonitrile to afford the corresponding aziridines by the use of one equimolar amount of Chloramine-T [Ts(Cl)N-] at room temperature and to afford the corresponding 1,2-diamines by the use of excess Chloramine-T at 50 degrees C.

  DOI：

  10.3987/com-05-s(t)43

文献信息

• Methods of preparing manganese complexes of nitrogen-containing
  申请人：Monsanto Company

  公开号：US05610293A1

  公开（公告）日：1997-03-11

  The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: ##STR1## wherein R, R', R.sub.1, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3, R'.sub.3, R.sub.4, R'.sub.4, R.sub.5, R'.sub.5, R.sub.6, R'.sub.6, R.sub.7, R'.sub.7, R.sub.8, R'.sub.8, R.sub.9, and R'.sub.9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.

  本发明涉及超氧化物歧化酶（SOD）的低分子量模拟物，其化学式如下：##STR1## 其中R、R'、R₁、R'₁、R₂、R'₂、R₃、R'₃、R₄、R'₄、R₅、R'₅、R₆、R'₆、R₇、R'₇、R₈、R'₈、R₉和R'₉以及X、Y、Z和n的定义如本文所述，可用作治疗炎症性疾病状态和紊乱、缺血/再灌注损伤、中风、动脉粥样硬化、高血压和所有其他由氧化剂引起的组织损伤或损伤的条件。
• A Metal-Free Protocol for Aminofunctionalization of Olefins Using TsNBr₂
  作者：Kamal Krishna Rajbongshi、Indranirekha Saikia、Loukrakpam Dineshwori Chanu、Subhasish Roy、Prodeep Phukan

  DOI：10.1021/acs.joc.6b00785

  日期：2016.7.1

  proceeds rapidly under mild conditions with high regioselectivity. Olefins react with TsNBr2 in moist THF to form δ-amino ether at room temperature. Treatment of TsNBr2 with olefin in MeCN at room temperature produced imidazoline in high yield. Further modification of the reaction condition resulted in the development of a one-step procedure for the synthesis of N-acetyl,N′-tosyl diamine derivatives directly

  已经发现N，N-二溴-对甲苯磺酰胺（TsNBr 2）是用于各种氨基官能化反应的有效试剂。该试剂既可作为亲电子溴源，也可作为胺在不同条件下与烯烃反应，从而产生氨基醚，咪唑啉，二胺和氨基溴。该反应在温和条件下以高区域选择性快速进行。烯烃与TsNBr 2在潮湿的THF中反应，在室温下形成δ-氨基醚。在室温下，在MeCN中用烯烃处理TsNBr 2可以高产率生产咪唑啉。反应条件的进一步改变导致了一步合成步骤的发展。N-乙酰基，N'-甲苯磺酰基二胺衍生物直接来自烯烃。当烯烃与2.4摩尔当量TsNBr的处理2中K的存在2 CO 3，Ñ，Ñ在适中的产率获得'-ditosyl二胺衍生物。当在室温下在干燥的CH 2 Cl 2中用试剂处理烯烃时，观察到氨基溴的瞬时形成。
• Manganese complexes of nitrogen-containing macrocyclic ligands effective
  申请人：——

  公开号：US05637578A1

  公开（公告）日：1997-06-10

  The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: ##STR1## wherein R, R', R.sub.1, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3, R'.sub.3, R.sub.4, R'.sub.4, R.sub.5, R'.sub.5, R.sub.6, R'.sub.6, R.sub.7, R'.sub.7, R.sub.8, R'.sub.8, R.sub.9, and R'.sub.9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.

  本发明涉及超氧化物歧化酶（SOD）的低分子量模拟物，其化学式为：##STR1## 其中R、R'、R1、R'1、R2、R'2、R3、R'3、R4、R'4、R5、R'5、R6、R'6、R7、R'7、R8、R'8、R9和R'9以及X、Y、Z和n的定义如本文所述，作为治疗炎症性疾病状态和紊乱、缺血/再灌注损伤、中风、动脉粥样硬化、高血压以及其他氧化剂引起的组织损伤或损伤的治疗剂使用。
• Manganese complexes of nitrogen containing macrocyclic ligands effective as catalysts for dismutating superoxide
  申请人：MONSANTO COMPANY

  公开号：EP0524161A1

  公开（公告）日：1993-01-20

  The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: wherein R, R′, R₁, R′₁, R₂, R′₂, R₃, R′₃, R₄, R′₄, R₅, R′₅, R₆, R′₆, R₇, R′₇, R₈, R′₈, R₉, and R′₉ and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.

  本发明涉及由式表示的超氧化物歧化酶（SOD）的低分子量模拟物： 其中 R、R′、R₁、R′₁、R₂、R′₂、R₃、R′₃、R′₄、R′₄、R₅、R′₅、R₆、R′₆、R₇、R′₇、R₈、R₉、R₉ 和 R′₉ 以及 X、Y、Z 和 n 如本文所定义、可用作炎症性疾病和失调、缺血/再灌注损伤、中风、动脉粥样硬化、高血压和所有其他氧化剂诱发的组织损伤或伤害的治疗剂。
• PhI(OAc)2/I2 induced aziridination of alkenes with TsNH2 under mild conditions
  作者：Renhua Fan、Dongming Pu、Jianhong Gan、Bing Wang

  DOI：10.1016/j.tetlet.2008.05.143

  日期：2008.8

  The aziridination of alkenes with the direct use of p-toluenesulfonamide (TsNH2) was achieved by using PhI(OAc)(2) and I-2 under mild conditions. The reaction affords aziridines in moderate to good yields, and offers good manipulability by avoiding the use of the expensive metal catalyst and the unstable and explosive PhI=NTs. (C) 2008 Elsevier Ltd. All rights reserved.