Phenol, 4-[[(4-methoxyphenyl)imino]methyl]-, (E)- | 3230-50-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phenol, 4-[[(4-methoxyphenyl)imino]methyl]-, (E)-
• 英文别名: 4-[(4-methoxyanilino)methylidene]cyclohexa-2,5-dien-1-one；(E)-4-(((4-methoxyphenyl)imino)methyl)phenol；4-(4-hydroxyphenyl)-N-(4-methoxyphenyl)imine；4-[N-(4-methoxyphenyl)formimidoyl]phenol；N-(4-Hydroxybenzyliden)-4-methoxyanilin
• CAS: 3230-50-0；145771-82-0
• 化学式: C₁₄H₁₃NO₂
• 分子量: 227.263
• InChiKey: JFVWOEIMTLSAAO-XNTDXEJSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.15
• 重原子数：
  17.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  41.82
• 氢给体数：
  1.0
• 氢受体数：
  3.0

安全信息

• 海关编码：
  2925290090

反应信息

• 作为反应物：
  描述：

  Phenol, 4-[[(4-methoxyphenyl)imino]methyl]-, (E)- 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.25h， 生成 3-乙酰氧基-4-(4-乙酰氧基苯基)-N-(4-甲氧基苯基)氮杂环丁烷-2-酮
  参考文献：
  名称：

  Antibiotic-conjugated polyacrylate nanoparticles: New opportunities for development of anti-MRSA agents

  摘要：

  This report describes the preparation of polyacrylate nanoparticles in which an N-thiolated beta-lactam antibiotic is covalently conjugated onto the polymer framework. These nanoparticles are formed in water by emulsion polymerization of an acrylated antibiotic pre-dissolved in a liquid acrylate monomer (or mixture of co-monomers) in the presence of sodium dodecyl sulfate as a surfactant and potassium persulfate as a radical initiator. Dynamic light scattering analysis and electron microscopy images of these emulsions show that the nanoparticles are approximately 40 nm in diameter. The emulsions have potent in vitro antibacterial properties against methicillin-resistant Staphylococcus aureus and have improved bioactivity relative to the non-polymerized form of the antibiotic. A unique feature of this methodology is the ability to incorporate water-insoluble drugs directly into the nanoparticle framework without the need for post-synthetic modification. Additionally, the antibiotic properties of the nanoparticles can be modulated by changing the length or location of the acrylate linker on the drug monomer. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.09.098
• 作为产物：
  描述：

  4-hydroxybenzenediazonium tetrafluoroborate 在 sodium acetate 、 palladium diacetate 、 iron(II) chloride 作用下， 以 乙腈 为溶剂， 反应 12.0h， 生成 Phenol, 4-[[(4-methoxyphenyl)imino]methyl]-, (E)-
  参考文献：
  名称：

  4-羟基丁苯与芳基叠氮化物的铁催化硝基转移反应：通过C═C键裂解合成亚胺。

  摘要：

  打破C bondC债券以获取C═N债券的领域仍然不发达。报道了一种在非氧化条件下通过4-羟基苯乙烯与芳基叠氮化物的铁催化的腈转移反应产生亚胺的烯烃的C═C键裂解的新方案。各种顺序一锅法反应的成功表明，该方法的良好兼容性使其对于合成应用非常有吸引力。在实验观察的基础上，还提出了合理的反应机理。

  DOI：

  10.1021/acs.orglett.9b03160

文献信息

• Solvent-free synthesis of azomethines, spectral correlations and antimicrobial activities of some E-benzylidene-4-chlorobenzenamines
  作者：R. Suresh、S. P. Sakthinathan、D. Kamalakkannan、K. Ranganathan、K. Sathiyamoorthi、V. Mala、R. Arulkumaran、S. Vijayakumar、R. Sundararajan、G. Vanangamudi、M. Subramanian、G. Thirunarayanan、G. Vanaja、P. Kanagambal

  DOI：10.4314/bcse.v29i2.10

  日期：——

  Some azomethines including substituted benzylidene-4-chlorobenzenamines (E-imines) have been synthesized by fly-ash: PTS catalyzed microwave assisted condensation of 4-chloroaniline and substituted benzaldehydes under solvent-free conditions. The yield of the imines has been found to be more than 85%. The purity of all imines has been checked using their physical constants and UV, IR and NMR spectral data. These spectral data have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied. The antimicrobial activities of all imines have been studied using standard methods.

  一些偶氮甲碱，包括取代苄叉-4-氯苯胺（E-亚胺），已在无溶剂条件下通过飞灰：PTS催化的微波辅助缩合4-氯苯胺和取代苯甲醛合成。亚胺的产率已发现超过85%。所有亚胺的纯度已通过其物理常数以及紫外、红外和核磁共振光谱数据进行检查。这些光谱数据已通过单一和多元线性回归分析与Hammett取代常数以及F和R参数相关联。从统计分析的结果中，研究了取代基对上述光谱数据的影响。所有亚胺的抗菌活性已采用标准方法进行研究。
• Substituted-phenyl substituted-alkyl ethers and the preparation thereof
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04214094A1

  公开（公告）日：1980-07-22

  The present invention relates to new substituted-phenyl substituted-alkyl ethers and pharmaceutically acceptable salts thereof, which have hypolipidemic activity, and to processes for the preparation thereof, the compound having the following formula ##STR1## wherein R.sub.1 is lower alkyl, cycloalkyl, aryl, ar(lower)alkyl, a heterocyclic group or a group represented by the formula: ##STR2## wherein R.sub.3 and R.sub.4 are each hydrogen or lower alkyl, R.sub.5 is carboxy, esterified carboxy or hydroxymethyl and A is lower alkylene; R.sub.2 is hydrogen, lower alkyl, cycloalkyl, aryl, ar(lower)alkyl, a heterocyclic group or a group represented by the formula: ##STR3## and R.sub.6 is hydrogen, hydroxy or lower alkoxy; in which the aryl or the ar(lower)alkyl for R.sub.1 and R.sub.2 may be substituted with halogen, hydroxy or lower alkoxy, and when R.sub.1 and R.sub.2 are both lower alkyl, R.sub.1 and R.sub.2 may be linked together.

  本发明涉及新的取代苯基取代烷基醚及其药用盐，具有降脂活性，并涉及其制备方法，该化合物具有以下结构式 其中R.sub.1为较低烷基，环烷基，芳基，芳基(较低)烷基，杂环基团或由以下结构式表示的基团： 其中R.sub.3和R.sub.4各自为氢或较低烷基，R.sub.5为羧基，酯化羧基或羟甲基，A为较低烷基；R.sub.2为氢，较低烷基，环烷基，芳基，芳基(较低)烷基，杂环基团或由以下结构式表示的基团： R.sub.6为氢，羟基或较低烷氧基；其中R.sub.1和R.sub.2的芳基或芳基(较低)烷基可以被卤素，羟基或较低烷氧基取代，当R.sub.1和R.sub.2都是较低烷基时，R.sub.1和R.sub.2可以连接在一起。
• Discovery of Novel Coumarin-Schiff Base Hybrids as Potential Acetylcholinesterase Inhibitors: Design, Synthesis, Enzyme Inhibition, and Computational Studies
  作者：Aso Hameed Hasan、Faruq Azeez Abdulrahman、Ahmad J. Obaidullah、Hadil Faris Alotaibi、Mohammed M. Alanazi、Mahmoud A. Noamaan、Sankaranarayanan Murugesan、Syazwani Itri Amran、Ajmal R. Bhat、Joazaizulfazli Jamalis

  DOI：10.3390/ph16070971

  日期：——

  ase agents for the treatment of Alzheimer’s disease (AD), a series of novel Schiff base-coumarin hybrids was rationally designed, synthesized successfully, and structurally characterized using Fourier transform infrared (FTIR), Nuclear magnetic resonance (NMR), and High-Resolution Mass Spectrometry (HRMS) analyses. These hybrids were evaluated for their potential inhibitory effect on acetylcholinesterase

  为了发现治疗阿尔茨海默病（AD）的抗乙酰胆碱酯酶药物，我们合理设计、成功合成了一系列新型希夫碱-香豆素杂化物，并利用傅里叶变换红外（FTIR）、核磁共振（NMR）、和高分辨率质谱 (HRMS) 分析。评估了这些杂种对乙酰胆碱酯酶（AChE）的潜在抑制作用。它们均表现出优异的 AChE 抑制活性。IC50值范围为87.84至515.59 μg/mL；杂交体 13c 和 13d 的 IC50 值分别为 0.232 ± 0.011 和 0.190 ± 0.004 µM，显示出最有效的乙酰胆碱酯酶抑制剂 (AChEI) 活性。参比药物加兰他敏的 IC50 为 1.142 ± 0.027 µM。在 wB97XD/6-311++ G (d,p) 上计算反应性描述符，包括化学势 (μ)、化学硬度 (η)、亲电性 (ω)、凝聚福井函数和对偶描述符，以识别反应性变化设计的化合物。对所研究化合物的自然电荷模式的深入研究使人们对这些化合物与
• Facile and Novel Synthetic Approach, Molecular Docking, Molecular Dynamics, and Drug‐Likeness Evaluation of 9‐Substituted Acridine Derivatives as Dual Anticancer and Antimicrobial Agents
  作者：Mohamed G. Abouelenein、Mahmoud Basseem I. Mohamed、Mohamed M. Elsenety、Ahmed A. El‐Rashedy、Samirah H. Ghalib、Fatima Abdelgalil E. Mohamed、Nora M. A. El‐Ebiary、Abeer A. Ageeli

  DOI：10.1002/cbdv.202301986

  日期：——

  the present study, numerous acridine derivatives A1–A20 were synthesized via aromatic nucleophilic substitution (SNAr) reaction of 9-chloroacridine with carbonyl hydrazides, amines, or phenolic derivatives depending upon facile, novel, and eco-friendly approaches (Microwave and ultrasonication assisted synthesis). The structures of the new compounds were elucidated using spectroscopic methods. The title

  在本研究中，通过9-氯吖啶与羰基酰肼、胺或酚类衍生物的芳香族亲核取代（S NAr ）反应，采用简便、新颖且环保的方法（微波和超声处理）合成了多种吖啶衍生物A1 – A20辅助合成）。使用光谱方法阐明了新化合物的结构。使用多种测定方法评估了标题产品的抗菌、抗氧化和抗增殖活性。令人鼓舞的是，所研究的主流化合物显示出有希望的抗菌和抗癌活性。此后，通过一系列计算机研究对所研究的化合物的预期作用模式进行了争论。化合物A2和A3是最有前途的抗菌剂，而化合物A2 、 A5和A7显示出最具细胞毒性的活性。因此，进行化合物A2和A3的RMSD、RMSF、Rg和SASA分析，并计算MMPBSA。最后，研究了新型吖啶衍生物的 ADMET（吸收、分布、代谢、排泄和毒性）分析。测试化合物的现有筛选结果为开发基于吖啶支架的新型引人注目的抗菌剂和抗癌剂提供了鼓舞人心的基础。
• [EN] NANOPARTICLES FOR DRUG-DELIVERY<br/>[FR] NANOPARTICULES POUR APPORT DE MEDICAMENT
  申请人：UNIV SOUTH FLORIDA

  公开号：WO2005020933A3

  公开（公告）日：2005-06-09