Fmoc-D-Hyp(tBu) | 1276694-30-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Fmoc-D-Hyp(tBu)
• 英文别名: (2R,4R)-4-(tert-butoxy)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid；(2R,4R)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-[(2-methylpropan-2-yl)oxy]pyrrolidine-2-carboxylic acid
• CAS: 1276694-30-4
• 化学式: C₂₄H₂₇NO₅
• 分子量: 409.482
• InChiKey: WPBXBYOKQUEIDW-QVKFZJNVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Fmoc-D-Hyp(tBu) 在 四氢吡咯 、 硼烷四氢呋喃络合物 、 N,N-二异丙基乙胺 、 potassium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 2-((2R,4R)-4-(tert-butoxy)-2-(hydroxymethyl)pyrrolidin-1-yl)-N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)phenyl)acetamide
  参考文献：
  名称：

  Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors

  摘要：

  The synthesis and SAR for a novel series of pyrrolotriazines as pan-Aurora kinase inhibitors are described. Optimization of the cyclopropane carboxamide terminus of lead compound 1 resulted in analogs with high cellular activity and improved rat PK profiles. Notably, compound 17l demonstrated tumor growth inhibition in a mouse xenograft model. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.07.027

文献信息

• Glycine-replaced derivatives of [Pro 3 ,DLeu 9 ]TL, a temporin L analogue: Evaluation of antimicrobial, cytotoxic and hemolytic activities
  作者：Francesco Merlino、Alfonso Carotenuto、Bruno Casciaro、Francesca Martora、Maria Rosa Loffredo、Antonio Di Grazia、Ali M. Yousif、Diego Brancaccio、Luciana Palomba、Ettore Novellino、Massimiliano Galdiero、Maria Rosaria Iovene、Maria L. Mangoni、Paolo Grieco

  DOI：10.1016/j.ejmech.2017.08.040

  日期：2017.10

  designed and synthesized a new library of antimicrobial peptides correlated to [Pro3,DLeu9]TL 1, a temporin L derivative devoid of cytolytic effects in vitro, and investigated the correlation between the α-helical content of the compounds and their antibacterial, cytotoxic and hemolytic activities. We systematically replaced Gly in position 10 of reference peptide with several amino acids. Structure-activity

  在这项研究中，我们设计并合成了一个新的与[Pro 3，DLeu 9 ] TL 1相关的抗菌肽文库，该化合物是一种在体外没有溶细胞作用的temporin L衍生物，并研究了这些化合物的α-螺旋含量与它们的抗菌，细胞毒性和溶血活性。我们用几种氨基酸系统地取代了参考肽第10位的Gly。这些类似物的构效关系研究是通过抗微生物和细胞毒性试验以及CD光谱分析进行的。还完成了化合物10的NMR分析。同样，还通过研究某些代表性微生物菌株的膜扰动动力学，对最有前途的肽对从人皮肤分离的某些临床菌株的活性及其作用机理进行了评估。我们确定了具有令人感兴趣的特性的新型类似物，使其成为潜在的潜在应用有吸引力的铅化合物。
• Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors
  作者：Sunny Abraham、Michael J. Hadd、Lan Tran、Troy Vickers、Janice Sindac、Zdravko V. Milanov、Mark W. Holladay、Shripad S. Bhagwat、Helen Hua、Julia M. Ford Pulido、Merryl D. Cramer、Dana Gitnick、Joyce James、Alan Dao、Barbara Belli、Robert C. Armstrong、Daniel K. Treiber、Gang Liu

  DOI：10.1016/j.bmcl.2011.07.027

  日期：2011.9

  The synthesis and SAR for a novel series of pyrrolotriazines as pan-Aurora kinase inhibitors are described. Optimization of the cyclopropane carboxamide terminus of lead compound 1 resulted in analogs with high cellular activity and improved rat PK profiles. Notably, compound 17l demonstrated tumor growth inhibition in a mouse xenograft model. (C) 2011 Elsevier Ltd. All rights reserved.