cis-[PtCl2(isopropylamine)(dimethylamine] | 246245-69-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: cis-[PtCl2(isopropylamine)(dimethylamine]
• 英文别名: cis-[Pt(II)Cl2(NHMe2)(NH2-i-Pr)]；N-methylmethanamine;platinum(2+);propan-2-amine;dichloride
• CAS: 246245-69-2
• 化学式: C₅H₁₆Cl₂N₂Pt
• 分子量: 370.181
• InChiKey: MXNIQNBEDSOXOM-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  1.57
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  鸟苷酸 、 cis-[PtCl2(isopropylamine)(dimethylamine] 在 sodium perchlorate 作用下， 以 not given 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and characterization of new cis-[PtCl2(isopropylamine)(amine′)] compounds: cytotoxic activity and reactions with 5′-GMP compared with their trans-platinum isomers

  摘要：

  The synthesis and characterization of four new cis-platinum compounds of structural formula cis[PtCl2(NH2CH(CH3)(2))(amine')] (amine' = methylamine, dimethylamine, propylamine and butylamine) (2a-2d) are described. Cytotoxicity tests in tumor cell lines sensitive to cisplatin (CH1 and Pam 212) and resistant to cisplatin (CH1cisR, and Pam 212-ras) indicate that only compound 2a possesses cytotoxic activity in the cisplatin-sensitive cell line CH1, albeit much less than cis-DDP and also less than corresponding trans-platinum compounds with mixed aliphatic amines. The interactions of cis- (2a-2d) and trans- (3a-3d) [PtCl2(NH2CH(CH3)(2))(amine')] compounds with 5'-GMP in dilute NaClO4 (10 mM) were investigated by H-1 NMR spectroscopy, and the progress of the reactions was followed overnight. In all cases two product peaks are observed in the cis-complexes, because the compounds are not symmetric. Temperature-dependent studies have been performed, but no significant variation in product structure is observed. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0020-1693(02)01050-2
• 作为产物：
  描述：

  potassium chloride 、 cis-[PtI₂(isopropylamine)(dimethylamine] 在 silver nitrate 作用下， 以 水 为溶剂， 生成 cis-[PtCl2(isopropylamine)(dimethylamine]
  参考文献：
  名称：

  Synthesis and characterization of new cis-[PtCl2(isopropylamine)(amine′)] compounds: cytotoxic activity and reactions with 5′-GMP compared with their trans-platinum isomers

  摘要：

  The synthesis and characterization of four new cis-platinum compounds of structural formula cis[PtCl2(NH2CH(CH3)(2))(amine')] (amine' = methylamine, dimethylamine, propylamine and butylamine) (2a-2d) are described. Cytotoxicity tests in tumor cell lines sensitive to cisplatin (CH1 and Pam 212) and resistant to cisplatin (CH1cisR, and Pam 212-ras) indicate that only compound 2a possesses cytotoxic activity in the cisplatin-sensitive cell line CH1, albeit much less than cis-DDP and also less than corresponding trans-platinum compounds with mixed aliphatic amines. The interactions of cis- (2a-2d) and trans- (3a-3d) [PtCl2(NH2CH(CH3)(2))(amine')] compounds with 5'-GMP in dilute NaClO4 (10 mM) were investigated by H-1 NMR spectroscopy, and the progress of the reactions was followed overnight. In all cases two product peaks are observed in the cis-complexes, because the compounds are not symmetric. Temperature-dependent studies have been performed, but no significant variation in product structure is observed. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0020-1693(02)01050-2