diazenedicarboxylic acid | 504-89-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: diazenedicarboxylic acid
• 英文别名: Diazendicarbonsaeure；Azodiameisensaeure；Diimiddicarbonsaeure；Diimidocarbonsaeure；Azodicarbonsaeure；Azoameisensaeure；carboxyiminocarbamic acid
• CAS: 504-89-2
• 化学式: C₂H₂N₂O₄
• 分子量: 118.049
• InChiKey: USVVENVKYJZFMW-UHFFFAOYSA-N

物化性质

• 沸点：
  357.1±25.0 °C(Predicted)
• 密度：
  1.87±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  盐酸 、 diazenedicarboxylic acid 、 对苯醌 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Angeli; Jolles, Chemische Berichte, 1929, vol. 62, p. 2099

  摘要：

  DOI：
• 作为产物：
  描述：

  偶氮二甲酰胺 在 氢氧化钾 、 (2S)-N-methyl-1-phenylpropan-2-amine hydrate 、 乙醇 作用下， 生成 diazenedicarboxylic acid
  参考文献：
  名称：

  Thiele, Justus Liebigs Annalen der Chemie, 1892, vol. 271, p. 130

  摘要：

  DOI：
• 作为试剂：
  描述：

  (3aS,4S,6R,6aR)-6-(tert-butoxymethyl)-2,2-dimethyl-5-methylenetetrahydro-3aH-cyclopenta[d][1,3]-dioxol-4-ol 在 diazenedicarboxylic acid 、 偶氮二甲酸二异丙酯 、 氨 、 diethylzinc 、 三苯基膦 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 为溶剂， 反应 16.5h， 生成 9-((3aR,4R,6R,6aS)-4-(tert-butoxymethyl)-2,2-dimethyltetrahydrospiro[cyclopenta [d][1,3]dioxole-5,1'-cyclopropan]-6-yl)-9H-purin-6-amine
  参考文献：
  名称：

  Synthesis and antiviral activity of cyclopropyl-spirocarbocyclic adenosine, (4 R ,5 S ,6 R ,7 R )-4-(6-amino-9 H -purin-9-yl)-7-(hydroxymethyl)spiro[2.4]heptane-5,6-diol against hepatitis C virus

  摘要：

  An efficient method was developed for the synthesis of 6-exocyclic methylene carbocyclic intermediate 4. The Simmons-Smith cyclopropanation protocol was applied on the 6-exocyclic methylene of intermediate 4 and demonstrated its utility for the synthesis of novel class of a spiro-carbocyclic nucleoside analog 8. The titled compound 8 demonstrated a significant antiviral activity against HCV with EC(50) values of 0.273 and 0.368 mu M in genotypes 1A and 1B, respectively. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.012

文献信息

• Pesticidally active ketone and oxime derivatives
  申请人：Zambach Werner

  公开号：US20060128670A1

  公开（公告）日：2006-06-15

  Compounds of formula (I), wherein A 0 , A 1 , and A 2 are each independently of the others a bond or a C 1 -C 6 alkylene bridge; A 3 is a C 1 -C 6 alkylene bridge which is unsubstituted or substituted by from one to six identical or different substituents selected from halogen and C 3 -C 8 cycloalkyl; Y is, for example, 0, S, SO or S0 2 ; M is 0 or NOR 6 , X 1 , and X 2 are each independently of the other fluorine, chlorine or bromine; R 1 , R 2 and R 3 are, for example, H, halogen, OH, SH, CN, nitro, C 1 -C 6 alkyl, C 1 -C 6 halealkyl, C 1 -C 6 alkylcarbonyl, C 2 -C 6 alkenyl, C 2 -C 6 haloalkenyl or C 2 -C 6 alkynyl; Q is, for example, O, S, SO or SO 2 ; W is, for example, 0, S, SO, SO 2 , —C(═O)—O— or -0—C(═O)—; T is, for example, a bond, 0, S, SO, S0 2 , —C(═O)—O or -0-C(═O)—; D is CH or N; R 4 is, for example, H, halogen, OH, SH, CN, nitro, C 1 -C 6 alkyl or C 1 -C 6 haloalkyl; R 5 is, for example, C 1 -C 12 alkyl, C 3 -C 8 cycloalkyl or —N(R 7 ) 2 ; R 7 is H, C 1 -C 6 alkyl, C 1 -C 3 haloalkyl, C 1 -C 6 alkylcarbonyl, C 1 -C 3 haloalkylcarbonyl, C 1 -C 6 alkoxycarbonyl, C 3 -C 8 Cycloalkyl, C 3 -C 8 cycloalkyl-carbonyl or formyl; k is 0, 1, 2, 3 or 4; m is 1 or 2; and q is 0, 1 or 2; and, where applicable, their possible E/Z isomers, E/Z isomeric mixtures and/or tautomers, in each case in free form or in salt form, a process for the preparation of those compounds and their use, pesticidal compositions in which the active ingredient has been selected from those compounds and agrochemically acceptable salts thereof, and a process for the preparation of those compositions and their use, to plant propagation material treated with those compositions, and a method of controlling pests.

  化学式为（I）的化合物，其中A0，A1和A2各自独立地为键或C1-C6烷基桥；A3是未取代或被从卤素和C3-C8环烷基中选择的一个到六个相同或不同的取代基所取代的C1-C6烷基桥；Y是，例如，0，S，SO或S02；M为0或NOR6，X1和X2分别独立地为氟，氯或溴；R1，R2和R3为，例如，H，卤素，OH，SH，CN，硝基，C1-C6烷基，C1-C6卤代烷基，C1-C6烷基羰基，C2-C6烯基，C2-C6卤代烯基或C2-C6炔基；Q是，例如，O，S，SO或SO2；W是，例如，0，S，SO，SO2，-C（═O）-O-或-0-C（═O）-；T是，例如，键，0，S，SO，S02，-C（═O）-O或-0-C（═O）-；D是CH或N；R4为，例如，H，卤素，OH，SH，CN，硝基，C1-C6烷基或C1-C6卤代烷基；R5是，例如，C1-C12烷基，C3-C8环烷基或-N（R7）2；R7为H，C1-C6烷基，C1-C3卤代烷基，C1-C6烷基羰基，C1-C3卤代烷基羰基，C1-C6烷氧羰基，C3-C8环烷基，C3-C8环烷基羰基或甲酰基；k为0，1，2，3或4；m为1或2；q为0，1或2；在适用的情况下，它们可能的E/Z异构体，E/Z异构体混合物和/或互变异构体，每种情况下均为自由形式或盐形式，制备这些化合物的方法及其用途，所述活性成分已从这些化合物中选择，并且是农药组合物和农业化学上可接受的盐，制备这些组合物的方法及其用途，用于处理这些组合物的植物繁殖材料，以及控制害虫的方法。
• Optically active substance and liquid crystal composition comprising same
  申请人：Mitsubishi Rayon Company Ltd.

  公开号：US05124069A1

  公开（公告）日：1992-06-23

  Disclosed is an optically active substance represented by the formula: ##STR1## wherein m is an integer of 1 to 14, Y is ##STR2## R is --C.sub.n H.sub.2n+1, --OC.sub.n H.sub.2n+1, --OCOC.sub.n H.sub.2n+1 or --COOC.sub.n H.sub.2n+1 (in which n is an integer of 1 to 18), each of the asterisked carbon atoms is an asymmetric carbon atom, X a single bond, --CO.sub.2 --, or --OCO--, and A.sub.1 and A.sub.2 is hydrogen, fluorine, chlorine, bromine, cyano or methoxy.

  本发明公开了一种光学活性物质，其化学式表示为：##STR1## 其中，m为1至14的整数，Y为##STR2## R为--C.sub.n H.sub.2n+1，--OC.sub.n H.sub.2n+1，--OCOC.sub.n H.sub.2n+1或--COOC.sub.n H.sub.2n+1（其中n为1至18的整数），每个星号标记的碳原子均为不对称碳原子，X为单键，--CO.sub.2 --或--OCO--，A.sub.1和A.sub.2为氢、氟、氯、溴、氰或甲氧基。
• Angeli; Jolles, Chemische Berichte, 1929, vol. 62, p. 2099
  作者：Angeli、Jolles

  DOI：——

  日期：——
• Synthesis and antiviral activity of cyclopropyl-spirocarbocyclic adenosine, (4 R ,5 S ,6 R ,7 R )-4-(6-amino-9 H -purin-9-yl)-7-(hydroxymethyl)spiro[2.4]heptane-5,6-diol against hepatitis C virus
  作者：Srinivas Gadthula、Ravindra K. Rawal、Ashoke Sharon、Dong Wu、Brent Korba、Chung K. Chu

  DOI：10.1016/j.bmcl.2011.05.012

  日期：2011.7

  An efficient method was developed for the synthesis of 6-exocyclic methylene carbocyclic intermediate 4. The Simmons-Smith cyclopropanation protocol was applied on the 6-exocyclic methylene of intermediate 4 and demonstrated its utility for the synthesis of novel class of a spiro-carbocyclic nucleoside analog 8. The titled compound 8 demonstrated a significant antiviral activity against HCV with EC(50) values of 0.273 and 0.368 mu M in genotypes 1A and 1B, respectively. (C) 2011 Elsevier Ltd. All rights reserved.
• Thiele, Justus Liebigs Annalen der Chemie, 1892, vol. 271, p. 130
  作者：Thiele

  DOI：——

  日期：——