methyl (1R,2R,11R,14R,15R,18S,21R,22R,23R)-2,10,10,14,15-pentamethyl-21-prop-1-en-2-yl-5,8-diazahexacyclo[12.11.0.02,11.04,9.015,23.018,22]pentacosa-4,6,8-triene-18-carboxylate | 936617-84-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: methyl (1R,2R,11R,14R,15R,18S,21R,22R,23R)-2,10,10,14,15-pentamethyl-21-prop-1-en-2-yl-5,8-diazahexacyclo[12.11.0.02,11.04,9.015,23.018,22]pentacosa-4,6,8-triene-18-carboxylate
• CAS: 936617-84-4
• 化学式: C₃₃H₄₈N₂O₂
• 分子量: 504.756
• InChiKey: ZOKLUSVJFRWYND-BFDLOSFQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  37
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  52.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl (1R,2R,11R,14R,15R,18S,21R,22R,23R)-2,10,10,14,15-pentamethyl-21-prop-1-en-2-yl-5,8-diazahexacyclo[12.11.0.02,11.04,9.015,23.018,22]pentacosa-4,6,8-triene-18-carboxylate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以44%的产率得到[(1R,2R,11R,14R,15R,18S,21R,22R,23R)-2,10,10,14,15-pentamethyl-21-prop-1-en-2-yl-5,8-diazahexacyclo[12.11.0.02,11.04,9.015,23.018,22]pentacosa-4,6,8-trien-18-yl]methanol
  参考文献：
  名称：

  Triterpenoid Pyrazines and Benzopyrazines with Cytotoxic Activity

  摘要：

  Twelve lupane, 18 alpha-oleanane, and des-E-lupane derivatives (1a-5b) were either extracted from natural sources or synthesized from betulinic acid (1a) and betulin (2). Compounds 1b, 1c, 3b, 3c, 4b, 4c, 5a, and 5b were then used as starting materials for further synthesis of a series of pyrazines and benzopyrazines (6a-18); 20 of them are new (6a-6e, 7a-7d, and 10a-18). Activity of pyrazine 6a against the T-lymphoblastic leukemia cell line CEM encouraged us to synthesize several new esters (6b-6d) to study structure-activity relationships with respect to substitution of the carboxyl group at position 28. The synthesized compounds were tested for cytotoxicity against a variety of cancer cell lines of different histogenetic origin, and the results were compared with cytotoxicity of the known starting compounds. Significant cytotoxic activity against A 549, K 562, and multidrug-resistant K 562-tax cell lines was found in pyrazines 6a, 6d, and 6e.

  DOI：

  10.1021/np060436d
• 作为产物：
  描述：

  白桦脂酸 在 吗啉 、 chromium(VI) oxide 、 sulfur 作用下， 以 乙醚 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 生成 methyl (1R,2R,11R,14R,15R,18S,21R,22R,23R)-2,10,10,14,15-pentamethyl-21-prop-1-en-2-yl-5,8-diazahexacyclo[12.11.0.02,11.04,9.015,23.018,22]pentacosa-4,6,8-triene-18-carboxylate
  参考文献：
  名称：

  Triterpenoid Pyrazines and Benzopyrazines with Cytotoxic Activity

  摘要：

  Twelve lupane, 18 alpha-oleanane, and des-E-lupane derivatives (1a-5b) were either extracted from natural sources or synthesized from betulinic acid (1a) and betulin (2). Compounds 1b, 1c, 3b, 3c, 4b, 4c, 5a, and 5b were then used as starting materials for further synthesis of a series of pyrazines and benzopyrazines (6a-18); 20 of them are new (6a-6e, 7a-7d, and 10a-18). Activity of pyrazine 6a against the T-lymphoblastic leukemia cell line CEM encouraged us to synthesize several new esters (6b-6d) to study structure-activity relationships with respect to substitution of the carboxyl group at position 28. The synthesized compounds were tested for cytotoxicity against a variety of cancer cell lines of different histogenetic origin, and the results were compared with cytotoxicity of the known starting compounds. Significant cytotoxic activity against A 549, K 562, and multidrug-resistant K 562-tax cell lines was found in pyrazines 6a, 6d, and 6e.

  DOI：

  10.1021/np060436d

文献信息

• Synthesis and evaluation of 2,3-indolotriterpenoids as new α-glucosidase inhibitors
  作者：Elmira F. Khusnutdinova、Irina E. Smirnova、Oxana B. Kazakova、Anastasiya V. Petrova、Nguyen Thi Thu Ha、Do Quoc Viet

  DOI：10.1007/s00044-017-1972-0

  日期：2017.11

  AbstractA series of ring-A fused heterocycles of lupane, oleanane, ursane and dammarane triterpenoids were synthesized and evaluated for their inhibitory activity against α-glucosidase. An influence of the different types of triterpenoids with indole and pyrazine cycles on the activity was revealed. Among them, 2,3-indolo-lup-20(29)-en-28-oic acid with an IC50 of 1.8 µM was the most active compound

  摘要合成了一系列环戊烷，齐墩果烷，乌尔烷和达玛烷三萜类化合物的A环稠合杂环，并评估了其对α-葡萄糖苷酶的抑制活性。揭示了吲哚和吡嗪循环不同类型的三萜类化合物对活性的影响。其中，IC 50为1.8 µM的2,3-吲哚-lup-20（29）-en-28-油酸是活性最高的化合物，其活性是市售阿卡波糖的221倍。在大多数情况下，用吡嗪片段取代吲哚会降低活性（除了达玛烷型吡嗪衍生物）。 图形概要
• Triterpenoid Pyrazines and Benzopyrazines with Cytotoxic Activity
  作者：Milan Urban、Jan Sarek、Miroslav Kvasnica、Iva Tislerova、Marian Hajduch

  DOI：10.1021/np060436d

  日期：2007.4.1

  Twelve lupane, 18 alpha-oleanane, and des-E-lupane derivatives (1a-5b) were either extracted from natural sources or synthesized from betulinic acid (1a) and betulin (2). Compounds 1b, 1c, 3b, 3c, 4b, 4c, 5a, and 5b were then used as starting materials for further synthesis of a series of pyrazines and benzopyrazines (6a-18); 20 of them are new (6a-6e, 7a-7d, and 10a-18). Activity of pyrazine 6a against the T-lymphoblastic leukemia cell line CEM encouraged us to synthesize several new esters (6b-6d) to study structure-activity relationships with respect to substitution of the carboxyl group at position 28. The synthesized compounds were tested for cytotoxicity against a variety of cancer cell lines of different histogenetic origin, and the results were compared with cytotoxicity of the known starting compounds. Significant cytotoxic activity against A 549, K 562, and multidrug-resistant K 562-tax cell lines was found in pyrazines 6a, 6d, and 6e.