1,3-bis<(tert-butoxycarbonyl)amino>-2-(p-tolylsulfonyloxy)-propan | 98642-16-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-bis<(tert-butoxycarbonyl)amino>-2-(p-tolylsulfonyloxy)-propan
• 英文别名: (1,3-bis-2-propyl) p-toluenesulfonate；2,2,12,12-tetramethyl-4,10-dioxo-3,11-dioxa-5,9-diazatridecan-7-yl 4-methylbenzenesulfonate；1-t-Butoxycarbonylaminomethyl-2-t-butoxycarbonylaminoethyl tosylate；1,3-di(tert-butyloxycarbonylamino)-2-(p-toluenesulfonyloxy) propane；1,3-Di(tert-butyloxycarbonylamino)-2-(p-toluenesulfonyloxy)propane；1,3-bis[(2-methylpropan-2-yl)oxycarbonylamino]propan-2-yl 4-methylbenzenesulfonate
• CAS: 98642-16-1
• 化学式: C₂₀H₃₂N₂O₇S
• 分子量: 444.549
• InChiKey: UOLKSDQVOSPWRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  128
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1,3-bis<(tert-butoxycarbonyl)amino>-2-(p-tolylsulfonyloxy)-propan 在 硫化氢 、 三乙胺 作用下， 以 乙醇 、 二甲基亚砜 为溶剂， 反应 74.0h， 生成 3--2-<(N-(tert-butoxycarbonyl)amino)methyl>thiopropionamide
  参考文献：
  名称：

  Guanosine-Specific DNA Damage by a Co(II).cntdot.Bithiazole Complex

  摘要：

  A bithiazole derivative structurally related to the bithiazole moiety of bleomycin (BLM) A(2) was prepared. This derivative contained a 2-(1,3-diaminopropyl) substituent, rather than the 2-(2-aminoethyl) substituent normally present in BLM, in order to facilitate metal coordination by the bithiazole moiety itself. In the presence of Co2+, th, modified bithiazole mediated the production of alkali labile lesions on double-stranded DNA. Following treatment with alkali, guanosine-specific DNA strand scission was observed. DNA degradation by this Co(II). bithiazole complex was not light dependent but did require molecular oxygen. DNA cleavage studies employing scavengers of activated oxygen species suggested that the observed DNA damage did not result from diffusible, activated forms of oxygen. Moreover, ESR spectroscopy utilizing a spin trapping reagent demonstrated conclusively that the Co(II). bithiazole complex did not produce diffusible oxygen radicals. Absorption spectroscopy with a thiazole analog of the modified bithiazole suggested that, in the presence of oxygen, a O-2 . Co . thiazole complex was formed. These mechanistic studies suggested that the (oxygenated) Co(II). bithiazole complex mediated the oxidative alteration or liberation of the guanine base, producing an alkali labile site. Further, the guanosine specificity appeared to derive from preferential reactivity at guanosine sites, as opposed to a guanosine binding selectivity of the bithiazole. The oxidative degradation of G residues in DNA appears to proceed by an inner sphere mechanism.

  DOI：

  10.1021/ja00141a001
• 作为产物：
  描述：

  1,3-二-(Boc-氨基)-2-羟基丙烷 生成 1,3-bis<(tert-butoxycarbonyl)amino>-2-(p-tolylsulfonyloxy)-propan
  参考文献：
  名称：

  FURUKAWA, MINORU;SATO, MAKOTO

  摘要：

  DOI：

文献信息

• Therapeutic use of acyl glycerols and the nitrogen- and sulphur- containing analogues thereof
  申请人：Darteil Raphael

  公开号：US20060154984A1

  公开（公告）日：2006-07-13

  The invention relates to the use of acyl glycerols and the nitrogen- and sulfur-containing analogues thereof in the therapeutic field, particularly in human health. The inventive compounds have advantageous pharmacological properties and are particularly of use for the prevention or treatment of neurodegenerative diseases.

  这项发明涉及在治疗领域中使用酰基甘油及其氮和硫含量类似物，特别是在人类健康领域。这些创新化合物具有有益的药理特性，特别适用于预防或治疗神经退行性疾病。
• Acylated aminopropanediols and analogues and therapeutic uses thereof
  申请人：Darteil Raphael

  公开号：US20060069156A1

  公开（公告）日：2006-03-30

  The invention relates to novel acylated aminopropanediols and the nitrogen and sulfur analogues thereof, pharmaceutical compositions comprising same, therapeutic uses thereof, in particular for the treatment of cerebral ischemia. The invention also provides a method of preparing said derivatives.

  该发明涉及新型酰化氨基丙二醇及其氮和硫类似物，包括这些化合物的药物组合物，其治疗用途，特别是用于治疗脑缺血。该发明还提供了制备这些衍生物的方法。
• Uses of acylated aminopropanediols and sulphur and nitrogen analogues of same f
  申请人：Najib Jamila

  公开号：US20060035977A1

  公开（公告）日：2006-02-16

  The invention relates to the use of molecules, particularly in the fields of human and veterinary health and cosmetics. The inventive compounds are acylated aminopropanediols and the nitrogen- and sulfur-containing analogues thereof and have advantageous pharmacological and cosmetic properties. In particular, the inventive compounds can be used to prevent and/or treat dyslipidemias, cardiovascular diseases, syndrome X, restenosis, diabetes, obesity, hypertension, some cancers, dermatological diseases, and, in the field of cosmetics, to combat skin ageing and the effects of same, in particular the development of wrinkles and the like.

  这项发明涉及分子的使用，特别是在人类和兽医健康以及化妆品领域。这些创新化合物是酰化氨基丙二醇及其氮和硫含量的类似物，具有有益的药理学和化妆品特性。特别是，这些创新化合物可以用于预防和/或治疗脂质代谢异常、心血管疾病、X综合征、再狭窄、糖尿病、肥胖、高血压、某些癌症、皮肤病，以及在化妆品领域中，用于对抗皮肤衰老及其效应，特别是皱纹等的发展。
• [EN] SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES<br/>[FR] INHIBITEURS À PETITES MOLÉCULES DE KINASES INDUCTIBLES PAR LE SEL
  申请人：JANSSEN BIOTECH INC

  公开号：WO2022165529A1

  公开（公告）日：2022-08-04

  Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

  提供了盐诱导激酶(SIKs)的小分子抑制剂。特别地，提供了式(I)化合物及其互变异构体、立体异构体、药学上可接受的盐和溶剂化物。还提供了包含该化合物的药物组合物，制备该化合物的方法，以及用于抑制SIKs，如SIK1和SIK2，并用于治疗由SIKs介导的疾病的方法。
• Brunner, Henri; Obermeier, Herbert; Szeimies, Rolf-Markus, Chemische Berichte, 1995, vol. 128, # 2, p. 173 - 182
  作者：Brunner, Henri、Obermeier, Herbert、Szeimies, Rolf-Markus

  DOI：——

  日期：——