3-carbamoyl-1-(cyanomethyl)pyridinium chloride | 64881-10-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-carbamoyl-1-(cyanomethyl)pyridinium chloride
• 英文别名: 1-(Cyanomethyl)pyridin-1-ium-3-carboximidate;hydrochloride
• CAS: 64881-10-3
• 化学式: C₈H₈N₃O*Cl
• mdl: MFCD00160344
• 分子量: 197.624
• InChiKey: NIDFUHVAOKTSPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  70.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  3-carbamoyl-1-(cyanomethyl)pyridinium chloride 、 2,3-二羟基苯甲醛 以 水 为溶剂， 反应 16.0h， 生成 4-hydroxy-12H-chromeno[2',3':4,5]imidazo[1,2-a]pyridine-9-carboxamide 、 4-hydroxy-12H-chromeno[2',3':4,5]imidazo[1,2-a]pyridine-7-carboxamide
  参考文献：
  名称：

  一锅法在水性介质中合成新型12 H -chromeno [2'，3'：4,5]咪唑并[1,2- a ]吡啶

  摘要：

  在包含水杨醛和1-（氰甲基）吡啶鎓氯化物的一锅缩合/环化反应中，在碳酸钠水溶液中生成了铬诺-咪唑并[1,2- a ]吡啶骨架。这些新型化合物的分离产率为47-71％。反应路径之后是1 H NMR光谱，可以清楚地了解该过程中涉及的副反应。 合成了不同的单取代吡啶鎓氯化物，并使其与单取代水杨醛反应，并对该合成方法的范围进行了详细讨论。

  DOI：

  10.1016/j.tet.2010.04.059
• 作为产物：
  描述：

  烟酰胺 、 氯乙腈 以 乙腈 为溶剂， 反应 7.0h， 以95%的产率得到3-carbamoyl-1-(cyanomethyl)pyridinium chloride
  参考文献：
  名称：

  一锅法在水性介质中合成新型12 H -chromeno [2'，3'：4,5]咪唑并[1,2- a ]吡啶

  摘要：

  在包含水杨醛和1-（氰甲基）吡啶鎓氯化物的一锅缩合/环化反应中，在碳酸钠水溶液中生成了铬诺-咪唑并[1,2- a ]吡啶骨架。这些新型化合物的分离产率为47-71％。反应路径之后是1 H NMR光谱，可以清楚地了解该过程中涉及的副反应。 合成了不同的单取代吡啶鎓氯化物，并使其与单取代水杨醛反应，并对该合成方法的范围进行了详细讨论。

  DOI：

  10.1016/j.tet.2010.04.059

文献信息

• UTILIZING ELECTROMAGNETIC RADIATION TO ACTIVATE FILTERCAKE BREAKERS DOWNHOLE
  申请人：Horton Amy C.

  公开号：US20100263867A1

  公开（公告）日：2010-10-21

  A downhole wellbore filtercake breaker is disclosed comprising one or more breaker chemicals (or activators thereof) capable of being activated with radiation to form one or more breaker reaction products which in turn are capable of reacting with the filtercake to chemically break down the filtercake. There is also disclosed a conventional reservoir drilling fluid modified to include an inactive, delayed, or sequestered breaker chemical or an activator thereof, wherein the breaker chemical (or activator) may be activated directly or indirectly by radiation, such as, microwave, visible, uV, soft x-ray, or other electromagnetic radiation. Also disclosed are methods for creating these filtercakes, and then breaking them via deploying a source of radiation that can be energized proximate to the filtercake. The breaker may be regenerated downhole by reaction with the filtercake breakdown products, and subjected again to a source of radiation to continue the breakdown of filtercake.
• [EN] UTILIZING ELECTROMAGNETIC RADIATION TO ACTIVATE FILTERCAKE BREAKERS DOWNHOLE<br/>[FR] UTILISATION D'UN RAYONNEMENT ÉLECTROMAGNÉTIQUE POUR ACTIVER DES DISPOSITIFS DE RUPTURE DE GÂTEAU DE FILTRATION EN FOND DE TROU
  申请人：HORTON AMY C

  公开号：WO2010123963A2

  公开（公告）日：2010-10-28

  A downhole wellbore filtercake breaker is disclosed comprising one or more breaker chemicals (or activators thereof) capable of being activated with radiation to form one or more breaker reaction products which in turn are capable of reacting with the filtercake to chemically break down the filtercake. Thre is also disclosed a conventional reservoir drilling fluid modified to include an inactive, delayed, or sequestered breaker chemical or an activator thereof, wherein the breaker chemical (or activator) may be activated directly or indirectly by radiation, such as, microwave, visible, uV, soft x-ray, or other electromagnetic radiation. Also disclosed are methods for creating these filtercakes, and then breaking them via deploying a source of radiation that can be energized proximate to the filtercake. The breaker may be regenerated downhole by reaction with the filtercake breakdown products, and subjected again to a source of radiation to continue the breakdown of filtercake.
• One-pot approach to the synthesis of novel 12H-chromeno[2′,3′:4,5]imidazo[1,2-a]pyridines in aqueous media
  作者：M. Fernanda Proença、Marta Costa

  DOI：10.1016/j.tet.2010.04.059

  日期：2010.6

  The chromeno-imidazo[1,2-a]pyridine scaffold was generated in an one pot condensation/cyclization reaction involving a salicylaldehyde and 1-(cyanomethyl)pyridinium chloride, in aqueous sodium carbonate solution. These novel compounds were isolated in 47–71% yield. The reaction pathway was followed by 1H NMR spectroscopy allowing a clear understanding of the side reactions involved in the process.

  在包含水杨醛和1-（氰甲基）吡啶鎓氯化物的一锅缩合/环化反应中，在碳酸钠水溶液中生成了铬诺-咪唑并[1,2- a ]吡啶骨架。这些新型化合物的分离产率为47-71％。反应路径之后是1 H NMR光谱，可以清楚地了解该过程中涉及的副反应。 合成了不同的单取代吡啶鎓氯化物，并使其与单取代水杨醛反应，并对该合成方法的范围进行了详细讨论。