THP ether of glycolic acid | 79582-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: THP ether of glycolic acid
• 英文别名: O-(tetrahydropyran-2yl)glycolic acid；2-tetrahydropyran-2-yloxyacetic acid；(tetrahydropyran-2-yloxy)acetic acid；glycolic acid THP-ether；2-((tetrahydro-2H-pyran-2-yl)oxy)acetic acid；2-(oxan-2-yloxy)acetic acid
• CAS: 79582-60-8
• 化学式: C₇H₁₂O₄
• 分子量: 160.17
• InChiKey: JWBQDXPJNGBSDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  THP ether of glycolic acid 在 lithium aluminium deuteride 作用下， 生成 monotetrahydropyranyl ether of [1,1-2H2]-ethylene glycol
  参考文献：
  名称：

  Electron impact induced water elimination from hydroxyamides. 1—N-(2′-hydroxyethyl)piperidone-2 andN-3′-hydroxypropyl piperidone-2

  摘要：

  AbstractThe main process of the electron impact induced water elimination of the title compounds takes a reaction course comprising several individual steps. A characteristic neighbouring group participation of the carbonyl function is involved, onto which a hydrogen is transferred in a first rate‐determining reaction step. This rearranged hydrogen is finally lost together with the hydroxyl group. The reaction of N‐(2′‐hydroxyethyl)piperidone follows what seems to be a [1,1] elimination whereas the H2O elimination from N‐(3′‐hydroxypropyl)piperidone represents a formal [1,2] elimination.

  DOI：

  10.1002/oms.1210180808
• 作为产物：
  描述：

  3,4-二氢-2H-吡喃 、 羟乙酸甲酯 在 对甲苯磺酸 、 lithium hydroxide 作用下， 以 二氯甲烷 、 甲醇 、 水 为溶剂， 反应 2.0h， 以30%的产率得到THP ether of glycolic acid
  参考文献：
  名称：

  PEPTIDE AMIDE COMPOUND AND PREPARATION METHOD AND MEDICAL USE THEREOF

  摘要：

  公开号：

  EP3656782B1

文献信息

• 5- substituted tetralones as inhibitors of ras farnesyl trransferase
  申请人：——

  公开号：US20040044057A1

  公开（公告）日：2004-03-04

  The present invention provides novel 5-substituted tetralones of Formulas (I), (II), (III) and (IV) and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme. 1

  本发明提供了式(I)、(II)、(III)和(IV)的新型5-取代四酮及其药学上可接受的盐、酯、酰胺和前药，用于治疗和预防组织的不受控制或异常增殖，如癌症、动脉粥样硬化、再狭窄和银屑病。具体而言，本发明涉及抑制法尼基转移酶酶的化合物。
• Solid phase synthesis of N-aminodipeptides in high optical purity
  作者：Anne-Sophie Felten、Régis Vanderesse、Nicolas Brosse、Claude Didierjean、Brigitte Jamart-Grégoire

  DOI：10.1016/j.tetlet.2007.10.152

  日期：2008.1

  N-Aminodipeptide derivatives can be easily prepared with high optical purity on solid phase via a Mitsunobu protocol between a solid supported α-hydroxyacid and a free phthaloylated α-Z-N-aminohydrazide.

  通过固载的α-羟基酸和游离的邻苯二甲酰化的α- Z - N-氨基酰肼之间的Mitsunobu方案，可以容易地在固相上以高光学纯度制备N-氨基二肽衍生物。
• [EN] METHOD FOR THE PREPARATION OF A 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONE<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UNE 1,2,4-TRIAZOLONE 2,4,5-TRISUBSTITUÉE
  申请人：BAYER AG

  公开号：WO2019197239A1

  公开（公告）日：2019-10-17

  The present invention provides methods for the preparation of Compound (I): Compound (I), the use of intermediates for the preparation of said compound and its crystalline form A.

  本发明提供了制备化合物(I)的方法：化合物(I)的制备方法，使用中间体制备所述化合物及其晶体形式A的用途。
• [EN] RESVERATROL GLYCOLATE AND TARTRATE DERIVATIVES AND SYNTHETIC METHODS THEREFOR<br/>[FR] DÉRIVÉS DE TARTRATE ET DE GLYCOLATE DE RESVÉRATROL ET LEURS PROCÉDÉS DE SYNTHÈSE
  申请人：ELC MAN LLC

  公开号：WO2017155875A1

  公开（公告）日：2017-09-14

  The invention is in the field of resveratrol derivative compounds and compositions, and methods for synthesizing same.

  这项发明涉及白藜芦醇衍生物化合物和组合物，以及其合成方法。
• [EN] CHIRAL DOPANT WITH PHENYLETHANEDIOL FUNCTIONALITY<br/>[FR] DOPANT CHIRAL PRESENTANT UNE FONCTIONNALITE PHENYLETHANEDIOL
  申请人：KONINKL PHILIPS ELECTRONICS NV

  公开号：WO2004002935A1

  公开（公告）日：2004-01-08

  The invention pertains to a phenylethanediol derivative having at least one polymerizable group, characterized in that the phenylethanediol derivative further comprises at least one photo-convertible group for adjusting the helical twisting power of the phenylethanediol derivative. According to a preferred embodiment the phenylethanediol has the formulawherein A stands for a bond or a p-phenylene group; B and B' are independently (O)p-CoH2o-O-CO-CR'=CH2, o being 2-12, p being 0 or 1, and R' being H or CH3; P stands for a CH2 or a C=O group; Q and Q' are independently selected from H, C1-C3 alkyl, C1-C3 alkoxy, halogen, and CN;n is an integer from 1 to 3; andm is an integer from 0 to 2; and:wherein A stands for a bond or a p-phenylene group; B is (O)p-CoH2o-O-CO-CR'=CH2, o being 2-12, p is 1, and R' being H or CH3; P stands for a CH2 or a C=O group; Q is selected from H, C1-C3 alkyl, C1-C3 alkoxy, halogen, and CN; andm is an integer from 0 to 2.

  本发明涉及一种具有至少一个可聚合基团的苯乙二醇衍生物，其特征在于该苯乙二醇衍生物进一步包含至少一个光可转换基团，用于调节苯乙二醇衍生物的螺旋扭转功率。根据首选实施例，苯乙二醇的式子为其中A代表键或p-苯撑基；B和B'独立地为（O）p-CoH2o-O-CO-CR'=CH2，其中o为2-12，p为0或1，R'为H或CH3；P代表CH2或C=O基团；Q和Q'独立地选自H、C1-C3烷基、C1-C3烷氧基、卤素和CN；n为1至3的整数；m为0至2的整数；和：其中A代表键或p-苯撑基；B为（O）p-CoH2o-O-CO-CR'=CH2，其中o为2-12，p为1，R'为H或CH3；P代表CH2或C=O基团；Q选自H、C1-C3烷基、C1-C3烷氧基、卤素和CN；m为0至2的整数。