2-ethoxy-2,3-dihydro-4H-1,3-benzoxazin-4-one | 34847-33-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 2-ethoxy-2,3-dihydro-4H-1,3-benzoxazin-4-one
• 英文别名: 2-ethoxy-2,3-dihydro-1,3-benzoxazin-4-one；2-ethoxy-2,3-dihydro-benzo[e][1,3]oxazin-4-one；2-ethoxy-2,3-dihydro-benz[e][1,3]oxazin-4-one；2-Aethoxy-2,3-dihydro-benz[e][1,3]oxazin-4-on；2-Aethoxy-2,3-dihydro-4H-1,3-benzoxazin-4-on
• CAS: 34847-33-1
• 化学式: C₁₀H₁₁NO₃
• 分子量: 193.202
• InChiKey: XVPBYTKSMQBVHH-UHFFFAOYSA-N

物化性质

• 熔点：
  124 °C
• 沸点：
  412.0±45.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-ethoxy-2,3-dihydro-4H-1,3-benzoxazin-4-one 在 锂硼氢 作用下， 以 四氢呋喃 为溶剂， 反应 13.0h， 生成 diethyl N-salicyloylaminomethanephosphonate
  参考文献：
  名称：

  Kosta, Krzysztof; Kotynski, Andrzej, Phosphorus, Sulfur and Silicon and the Related Elements, 1990, vol. 47, p. 261 - 265

  摘要：

  DOI：
• 作为产物：
  描述：

  原甲酸三乙酯 、 水杨酰胺 在 硫酸 作用下， 反应 3.0h， 以89%的产率得到2-ethoxy-2,3-dihydro-4H-1,3-benzoxazin-4-one
  参考文献：
  名称：

  The Reaction of Salicylamide with Triethyl Orthoformate.

  摘要：

  DOI：

  10.3891/acta.chem.scand.35b-0465

文献信息

• Ben-Ishai,D.; Warshawsky,A., Journal of Heterocyclic Chemistry, 1971, vol. 8, p. 865 - 866
  作者：Ben-Ishai,D.、Warshawsky,A.

  DOI：——

  日期：——
• Inhibitory effect of metalloporphyrins in conjunction with cholesterol on hepatic phospholipase A2 activityin vivo in rats
  作者：Ramesh Chandra、Manisha Tiwari、Ritu Aneja、Sujata K. Dass、Archana Sharma

  DOI：10.1007/bf02883744

  日期：2000.7

  We investigated the effect of cholesterol and the metalloporphyrins cobalt mesoporphyrin (CoMP) and chromium protoporphyrin (CrPP) on phospholipase A(2) (PLA(2)) activity and the consequent hepatic mitochondrial stability as well as on lipid concentrations. Our studies revealed that on administration of cholesterol, CrPP, CoMP as well as simultaneous adminstration of cholesterol and CrPP, there was an inhibition of PLA(2) activity. These moieties may therefore, be agents for preventing destabilisation of the mitochondrial membrane and the consequent pathological conditions which may arise due to membrane lysis. Our results revealed that cholesterol administration increased phospholipid concentration, albeit by modest amounts. Although the independent administration of metalloporphyrins led only to minor elevations in phospholipid concentration, the simultaneous administration of cholesterol and CrPP generated a steep elevation in the concentration of total phospholipid. Since cholesterol inhibits PLA(2) activity it has the potential of being therapeutic agent for preventing the pathological conditions which may arise due to membrane lysis.
• Irie et al., Nippon Kagaku Zasshi, 1958, vol. 79, p. 1401
  作者：Irie et al.

  DOI：——

  日期：——
• TREPPENDAHL, S.;JAKOBSEN, P., ACTA CHEM. SCAND., 1981, 35, N 6, 465-466
  作者：TREPPENDAHL, S.、JAKOBSEN, P.

  DOI：——

  日期：——
• The Reaction of Salicylamide with Triethyl Orthoformate.
  作者：Svend Treppendahl、Palle Jakobsen、Claudine Narbonne、Toshiaki Nishida、Curt R. Enzell

  DOI：10.3891/acta.chem.scand.35b-0465

  日期：——