2-(naphthalen-1-yl)ethyl acetate | 26157-05-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(naphthalen-1-yl)ethyl acetate
• 英文别名: 1-(2-acetoxyethyl)naphthalene；1-Naphthaleneethanol, acetate；2-naphthalen-1-ylethyl acetate
• CAS: 26157-05-1
• 化学式: C₁₄H₁₄O₂
• 分子量: 214.264
• InChiKey: ITZBHXFTXRVMIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2915390090

反应信息

• 作为反应物：
  描述：

  2-(naphthalen-1-yl)ethyl acetate 在 氢氧化钾 作用下， 生成 1-萘乙醇
  参考文献：
  名称：

  The Reaction of Olefins with Aromatic Substances in the Presence of Mercury Salts and Catalyst. II. Synthesis of β-Arylethyl Alcohols and sym-Diarylethanes

  摘要：

  DOI：

  10.1021/ja01555a030
• 作为产物：
  描述：

  1,2,3,4-四氢萘-1-乙醇 在 palladium on activated charcoal 、 对甲苯磺酸 、 苯 作用下， 生成 2-(naphthalen-1-yl)ethyl acetate
  参考文献：
  名称：

  The slippery slope of constructivism

  摘要：

  While constructivism as both a philosophy and a clinical practice is being embraced by many individual and family practitioners, it remains controversial. This paper examines the difficulties one encounters in trying to balance the client's "relative truths" with those around them, including that of the therapist. Through the use of clinical vignettes, the authors demonstrate the difficulties inherent in dealing with ambiguities in the clinical situation, balancing the client's perspective, with that of a predominant culture or biological "fact," and considering the issue of the client's "veracity." Particular attention is paid to the difficulties involved in work with trauma survivors, whose own recollections of events may be ambiguous. Finally, the authors discuss the implications that constructivism holds for research and social action and advocacy. In sum, the authors recognize significant promise in the constructivist perspective, but caution clinicians to consider the inherent difficulties in a theory that relies on the relativity of truth.

  DOI：

  10.1080/00377310209517656

文献信息

• Copper-Catalyzed Late-Stage Benzylic C(sp3)–H Trifluoromethylation
  作者：Haiwen Xiao、Zhonglin Liu、Haigen Shen、Benxiang Zhang、Lin Zhu、Chaozhong Li

  DOI：10.1016/j.chempr.2019.02.006

  日期：2019.4

  Direct trifluoromethylation of C(sp3)–H bonds, especially in late stages, remains a formidable challenge. Herein, we describe the copper-catalyzed benzylic C(sp3)–H trifluoromethylation. With Cu(I) or Cu(II) as the catalyst, (bpy)Zn(CF3)2 (bpy = 2,2′-bipyridine) as the CF3 source, and NFSI (or Selectfluor) as the oxidant, site-selective benzylic C(sp3)–H trifluoromethylation is successfully implemented

  C（sp 3）–H键的直接三氟甲基化，尤其是在后期阶段，仍然是一个艰巨的挑战。在这里，我们描述了铜催化的苄基C（sp 3）–H三氟甲基化。以Cu（I）或Cu（II）为催化剂，以（bpy）Zn（CF 3）2（bpy = 2,2'-联吡啶）作为CF 3源，以NFSI（或Selectfluor）作为氧化剂选择性苄基C（sp 3）–H三氟甲基化已在温和条件下成功高效地实施。该协议不仅展示了广泛的底物范围和广泛的官能团兼容性，而且还允许对天然产物或药物衍生物进行有效的后期C（sp 3）–H三氟甲基化。
• Light-Stabilized Dynamic Materials
  作者：Hannes A. Houck、Eva Blasco、Filip E. Du Prez、Christopher Barner-Kowollik

  DOI：10.1021/jacs.9b05092

  日期：2019.8.7

  of polymer materials typically requires different wavelengths or additional heat to induce reversible covalent bond formation and dissociation. Here, we bypass the use of invasive triggers by introducing light-stabilised dynamic materials that can undergo a repeatable change in topology from a covalently crosslinked material into a liquid polymer formulation by switching one visible light source on-and

  聚合物材料的光响应适应性通常需要不同的波长或额外的热量来诱导可逆的共价键形成和解离。在这里，我们通过引入光稳定的动态材料来绕过侵入性触发器的使用，这些材料可以通过打开和关闭一个可见光源而经历从共价交联材料到液体聚合物配方的拓扑结构的可重复变化，而无需任何额外的触发器。具体来说，我们利用三唑啉二酮与萘的光-狄尔斯-阿尔德反应作为动态共价交联平台，使绿光诱导网络形成，而交联材料在室温下放置在黑暗中时通过自发的环回复坍塌。重要的，只要存在可见光，共价交联就会保持稳定，从而保持材料的结构完整性。这使得它们在一系列光导向应用中具有潜在用途，其中网络特性（例如刚度）可以通过最温和的触发因素进行调整：黑暗。
• Enantioselective cyanation of benzylic C–H bonds via copper-catalyzed radical relay
  作者：Wen Zhang、Fei Wang、Scott D. McCann、Dinghai Wang、Pinhong Chen、Shannon S. Stahl、Guosheng Liu

  DOI：10.1126/science.aaf7783

  日期：2016.9.2

  sp3-hybridized carbon–hydrogen [C(sp3)–H] bonds in complex organic molecules could facilitate much more efficient preparation of therapeutics and agrochemicals. Here, we report a copper-catalyzed radical relay pathway for enantioselective conversion of benzylic C–H bonds into benzylic nitriles. Hydrogen-atom abstraction affords an achiral benzylic radical that undergoes asymmetric C(sp3)–CN bond formation upon

  复杂有机分子中 sp3 杂化碳氢 [C(sp3)-H] 键立体选择性功能化的直接方法可以促进治疗剂和农用化学品的更有效制备。在这里，我们报告了一种铜催化的自由基中继途径，用于对映选择性地将苄基 C-H 键转化为苄基腈。氢原子抽提得到非手性苄基自由基，该自由基在与手性铜催化剂反应时形成不对称 C(sp3)-CN 键。反应在室温下以苄基底物作为限制剂有效进行，底物范围广，对映选择性高（通常为 90% 至 99% 对映体过量），并提供作为重要生物活性分子的关键前体的产物。
• Copper-Catalyzed Alkynylation of Benzylic C–H Bonds with Alkynylboronic Esters
  作者：Søren Kramer、Mikkel B. Buendia、Jan-Georges J. Balin、Mette E. Andersen、Zhong Lian

  DOI：10.1055/s-0040-1720474

  日期：2022.1

  method for copper-catalyzed benzylic C–H alkynylation that uses alkynylboronic esters as nucleophilic coupling partners. The catalytic system is readily available and the reaction takes place under mild conditions. Different substrates for the C–H functionalization, as well as various alkynylboronic ester nucleophiles, were evaluated. Finally, three examples of enantioselective C–H alkynylations are presented

  我们报告了一种简单的铜催化苄基CH炔基化的简单方法，该方法使用炔基硼酸酯作为亲核偶联伙伴。催化体系很容易获得，反应在温和的条件下进行。对C–H功能化的不同底物以及各种炔基硼酸酯亲核试剂进行了评估。最后，给出了对映选择性C–H炔基化的三个例子。
• Carbapenem antibacterial compounds, compositions containing such
  申请人：Merck & Co., Inc.

  公开号：US06140318A1

  公开（公告）日：2000-10-31

  Compounds of formula I are disclosed. ##STR1## as well as pharmaceutically acceptable salts thereof. The naphthosultam is substituted with various substituent groups including at least one cationic group -A-Q-L-B. The carbapenems of the invention are effective against susceptible bacterial organisms, including methicillin resistant Staphylococcus aureus (MRSA), methicillin resistant Staphylococcus epidermidis (MRSE), and methicillin resistant coagulase negative Staphylococci (MRCNS).

  公式I的化合物已被披露。##STR1##以及其药用盐。萘磺胺酮被各种取代基替代，包括至少一个阳离子基团-A-Q-L-B。本发明的碳青霉烯对易感染的细菌有有效作用，包括耐甲氧西林金黄色葡萄球菌（MRSA）、耐甲氧西林表皮金黄色葡萄球菌（MRSE）和耐甲氧西林凝血酶阴性金黄色葡萄球菌（MRCNS）。