(1Ξ,2R)-2-methylamino-1-phenyl-propan-1-ol | 90-81-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1Ξ,2R)-2-methylamino-1-phenyl-propan-1-ol
• 英文别名: pseudoephedrine；d-Ephedrin；(2R)-2-(methylamino)-1-phenylpropan-1-ol
• CAS: 90-81-3；90-82-4；299-42-3；321-97-1；321-98-2；4125-58-0；34783-90-9；38732-95-5；53214-57-6
• 化学式: C₁₀H₁₅NO
• 分子量: 165.235
• InChiKey: KWGRBVOPPLSCSI-HNHGDDPOSA-N

物化性质

• 熔点：
  118-118.7 °C
• 沸点：
  255.0±0.0 °C(Predicted)
• 密度：
  1.015±0.06 g/cm3(Predicted)
• 稳定性/保质期：
  常温常压下稳定，避免与氧化剂接触。

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 储存条件：
  密封储存，存放在阴凉干燥的库房中，并避免阳光直射。

SDS

Name:	(1R 2R)-(-)-Pseudoephedrine Material Safety Data Sheet
Synonym:	Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, (R-(R*,R*))-; (1R,2R)-Ephedrine; (-)-Pseudoephedrine; D-Pseudoephedrine; L-Pseudoephedrine
CAS:	321-97-1

Section 1 - Chemical Product MSDS Name:(1R 2R)-(-)-Pseudoephedrine Material Safety Data Sheet
Synonym:Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, (R-(R*,R*))-; (1R,2R)-Ephedrine; (-)-Pseudoephedrine; D-Pseudoephedrine; L-Pseudoephedrine

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
321-97-1	(1R,2R)-(-)-Pseudoephedrine	ca 100	206-292-8

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Light sensitive.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 321-97-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystalline powder
Color: white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 117.00 - 118.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: slightly soluble in water
Specific Gravity/Density:
Molecular Formula: C10H15NO
Molecular Weight: 165.23

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, light, dust generation, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 321-97-1: UL5750500 LD50/LC50:
Not available.
Carcinogenicity:
(1R,2R)-(-)-Pseudoephedrine - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 321-97-1: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 321-97-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 321-97-1 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

制备方法： 呼吸系统用药。

用途简介：

用途： 呼吸系统用药。

文献信息

• A Process for the Preparation of R-(-)-N, Alpha-Dimethylphenethylamine (Levmethamfetamine) or S-(+)-N, Alpha-Dimethylphenethylamine (Methamphetamine) from D-Ephendrine, or L-Ephedrine Respectively
  申请人：Gollapudy Subrahmanyam

  公开号：US20080293971A1

  公开（公告）日：2008-11-27

  A process for synthesis of R-(−)-N,α-Dimethylphenethylamine (Levmetamfetamine, formula I), or S-(+)-N,α-Dimethyl phenethylamine (Methamphetamine, formula II), from d-ephedrine of formula III or l-ephedrine formula IV, the process comprising the steps of (a) acylating the d- or l-ephedrine base of formula III or formula IV with an acylating agent to make a reaction mixture containing a N-acylated ephedrines of formula V or formula VI; (b) deoxygenation of N-acylated ephedrines to make the compound of the formula VII or Formula VIII by using Raney Nickel catalyst; and (c) acid hydrolysis of the above deoxygenated products to get the levmetamfetamine or methamphetamine.

  一种从d-麻黄碱（式III）或l-麻黄碱（式IV）合成R-（-）-N，α-二甲基苯乙胺（左旋甲基苯丙胺，式I）或S-（+）-N，α-二甲基苯乙胺（甲基苯丙胺，式II）的方法，该方法包括以下步骤：（a）用酰化剂酰化式III或式IV的d-或l-麻黄碱基，制备含有式V或式VI的N-酰化麻黄碱的反应混合物；（b）使用Raney镍催化剂脱氧N-酰化麻黄碱，制备式VII或式VIII的化合物；（c）对上述脱氧产物进行酸水解，得到左旋甲基苯丙胺或甲基苯丙胺。
• Methods and compositions for making ephedrine and related alkaloid compounds
  申请人：Willow BioSciences Inc.

  公开号：US10676767B2

  公开（公告）日：2020-06-09

  Methods for making alkaloid compounds, including ephedrine and derivatives thereof. The methods involve the performance of an N-methyltransferase catalyzed chemical reaction.

  制造生物碱化合物，包括麻黄碱及其衍生物的方法。这些方法包括进行 N-甲基转移酶催化的化学反应。
• A PROCESS FOR THE PREPARATION OF R-(-)-N, ALPHA-DIMETHYLPHENETHYLAMINE (LEVMETAMFETAMINE) OR S-(+)-N, ALPHA-DIMETHYLPHENETHYLAMINE (METHAMPHETAMINE) FROM d-EPHEDRINE OR L-EPHEDRINE RESPECTIVELY
  申请人：Emmellen Biotech Pharmaceuticals Limited

  公开号：EP1828105B1

  公开（公告）日：2008-09-03
• PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES
  申请人：Moniz George A.

  公开号：US20110160463A1

  公开（公告）日：2011-06-30

  The present invention relates to methods of making compounds that inhibit 11-β-hydroxysteroid dehydrogenase type 1 enzyme (11-β HSD1). One method comprises (a) contacting a compound of formula (II) with a chiral base, deprotonating agent, and an alkylating agent R 3 -LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I); wherein Z, R 1 , R 2 , and R 3 are defined herein.
• US7534905B2
  申请人：——

  公开号：US7534905B2

  公开（公告）日：2009-05-19