(6-methoxynaphthalen-2-yl)hydrazine hydrochloride | 70488-60-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (6-methoxynaphthalen-2-yl)hydrazine hydrochloride
• 英文别名: (6-methoxynaphthalen-2-yl)hydrazine;hydrochloride
• CAS: 70488-60-7
• 化学式: C₁₁H₁₂N₂O*ClH
• 分子量: 224.69
• InChiKey: WJCHKQCZADORDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.56
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  47.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (6-methoxynaphthalen-2-yl)hydrazine hydrochloride 在 三甲基铝 、 三溴化硼 、 溶剂黄146 、 三氟乙酸 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 2-(6-Hydroxy-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide
  参考文献：
  名称：

  Design, synthesis and biological activity of novel non-amidine factor Xa inhibitors. Part 1: P1 structure–activity relationships of the substituted 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides

  摘要：

  Based on DuPont Pharmaceuticals' monobenzamidine lead structure SN429, we have designed the biphenyl 1-(2-naphthyl)-1H-pyrazole-5-carboxylamides as a novel series of non-basic factor Xa inhibitors. We have discovered that the displacement of the benzamidine moiety with substituted 2-naphthyl structures not only results in highly potent factor Xa inhibitors, but also significantly increases their enzyme specificity and oral bioavailability. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00239-1
• 作为产物：
  描述：

  2-溴-6-甲氧基萘 在 di-tert-butyl (E)-azodicarboxylate 作用下， 以 1,2-二氯乙烷 为溶剂， 以47%的产率得到(6-methoxynaphthalen-2-yl)hydrazine hydrochloride
  参考文献：
  名称：

  Process for the preparation of indazoles

  摘要：

  通过将有机金属试剂与偶氮二羧酸酯反应制备芳基肼和吲哚的方法。

  公开号：

  US04864032A1

文献信息

• NOVEL ORGANIC COMPOUND, NEAR-INFRARED FLUORESCENT CONSTANT MEDIUM CONTAINING SAME, AND METHOD FOR NANO-GRANULATING CONSTANT MEDIUM
  申请人：COLLEGE OF MEDICINE POCHON CHA UNIVERISTY INDUSTRY- ACADEMIC COOPERATION FOUNDATION

  公开号：US20180327357A1

  公开（公告）日：2018-11-15

  The present invention relates to a novel organic compound, a near-infrared fluorescent constant medium containing the same, and a method for nano-granulating the constant medium.

  本发明涉及一种新型的有机化合物，含有该化合物的近红外荧光恒定介质，以及用于纳米粒化该恒定介质的方法。
• Helicoselective Synthesis of Indolohelicenoids through Organocatalytic Central‐to‐Helical Chirality Conversion
  作者：Wen‐Lei Xu、Ru‐Xia Zhang、Hui Wang、Jie Chen、Ling Zhou

  DOI：10.1002/anie.202318021

  日期：2024.2.26

  A chiral-phosphoric-acid-catalyzed enantioselective cycloaddition-elimination cascade reaction was developed to access chiral azahelicenoid skeletons. This convergent approach offers an organocatalytic helicoselective route to obtain indolohelicenoids with high enantioselectivity. The prepared indolohelicenoids display positive photophysical and chiroptical properties, showcasing their potential utility

  开发了一种手性磷酸催化的对映选择性环加成-消除级联反应来获得手性氮杂螺烯骨架。这种收敛方法提供了一种有机催化螺旋选择性途径，以获得具有高对映选择性的吲哚螺烯类化合物。所制备的吲哚螺烯类化合物表现出正光物理和手性光学性质，展示了它们在有机光电材料中的潜在用途。
• Organocatalytic Atroposelective Construction of Pentatomic Heterobiaryl Diamines through Arylation of 5-Aminoisoxazoles with Azonaphthalenes
  作者：Weiwei Luo、Huanhuan Guo、Xueying Qiu、Meijun Ming、Lin Zhang、Hao Zhu、Jun Zhou

  DOI：10.1021/acs.orglett.4c00440

  日期：2024.4.5

  efficient catalytic asymmetric Michael-type reaction of azonaphthalenes with 5-aminoisoxazoles has been developed. The reaction was based on the utilization of a chiral phosphoric acid as the catalyst, delivering a large panel of axially chiral heterobiaryl diamines in generally good yields with excellent enantioselectivities. The gram-scale reaction and postmodification of the chiral product demonstrated

  偶氮萘与 5-氨基异恶唑的有效催化不对称迈克尔型反应已被开发出来。该反应基于使用手性磷酸作为催化剂，以良好的产率和优异的对映选择性产生大量轴向手性杂联芳二胺。手性产物的克级反应和后修饰证明了其在手性催化剂和配体合成中的潜力。这种方法不仅为构建五原子杂联芳基支架提供了一种有用的方法，而且还为轴向手性二胺家族提供了新成员，在合成和药物化学方面具有广阔的应用前景。
• Addition of arylmetallics to azodicarboxylates: A novel synthesis of arylhydrazines by aromatic hydrazination
  作者：James P. Demers、Dieter H. Klaubert

  DOI：10.1016/s0040-4039(00)96662-0

  日期：1987.1
• DEMERS, JAMES P.;KLAUBERT, DIETER H., TETRAHEDRON LETT., 28,(1987) N 42, 4933-4934
  作者：DEMERS, JAMES P.、KLAUBERT, DIETER H.

  DOI：——

  日期：——