2-phenylamino-6-methoxy-(1,2,3,4-tetrahydronaphthalene) | 52802-26-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-phenylamino-6-methoxy-(1,2,3,4-tetrahydronaphthalene)
• 英文别名: 6-methoxy-N-phenyl-tetralin-2-amine；6-methoxy-N-phenyl-1,2,3,4-tetrahydronaphthalen-2-amine
• CAS: 52802-26-3
• 化学式: C₁₇H₁₉NO
• 分子量: 253.344
• InChiKey: ZCTHUSIZYKFCRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-phenylamino-6-methoxy-(1,2,3,4-tetrahydronaphthalene) 、 氯乙酰氯 以 苯 为溶剂， 生成 2-(N-phenyl-N-chloroacetyl)-amino-6-methoxy-(1,2,3,4-tetrahydronaphthalene)
  参考文献：
  名称：

  Derivatives of 2-amino-(1,2,3,4-tetrahydronaphthalene), the preparation

  摘要：

  本发明涉及2-氨基-(1,2,3,4-四氢萘)的新衍生物，即2-[N-苯基-N-(R.sub.1，R.sub.2-氨基烷基或酰基)]-氨基-(1,2,3,4-四氢萘)，其中R.sub.1和R.sub.2代表较低的烷基或与连接的氮原子一起形成含氮杂环，但R.sub.1也可能代表氢，以及这些新衍生物的酸加成盐。这些新衍生物对治疗心律失常有活性。

  公开号：

  US03943172A1
• 作为产物：
  描述：

  6-methoxy-N-phenylnaphthalen-2-amine 在 三(五氟苯基)硼烷 、 氢气 作用下， 以 甲苯 为溶剂， 60.0 ℃ 、2.0 MPa 条件下， 反应 6.0h， 生成 2-phenylamino-6-methoxy-(1,2,3,4-tetrahydronaphthalene)
  参考文献：
  名称：

  B（C 6 F 5）3催化的萘胺的无金属氢化†

  摘要：

  使用B（C 6 F 5）3作为催化剂的萘胺的无催化金属氢化首次在温和条件下成功实现，以88-99％的产率提供了各种四氢萘胺。

  DOI：

  10.1039/c5ob00009b

文献信息

• Synthesis and Antifungal Activities of Novel 2-Aminotetralin Derivatives
  作者：Bin Yao、Haitao Ji、Yongbin Cao、Youjun Zhou、Jü Zhu、Jiaguo Lü、Yaowu Li、Jun Chen、Canhui Zheng、Yuanying Jiang、Rongmei Liang、Hui Tang

  DOI：10.1021/jm0701167

  日期：2007.11.1

  Novel 2-aminotetralin derivatives were synthesized as antifungal agents. The 2-aminotetralin scaffold was chemically designed to mimic the tetrahydroisoquinoli ne ring of the lead molecule described before. Their antifungal activities were evaluated in vitro by measuring the minimal inhibitory concentrations (MICs). Compounds 10a, 12a, 12c, 13b, and 13d are more potent than fluconazole against seven testing human fungal pathogens. Compound 10b exhibits much higher antifungal activities against all of the four fluconazole-resistant clinic Candida albicans strains than the control drugs including amphotericin B, terbinafine, ketoconazole, and itraconazole. The mode of action of some compounds to the potential receptor lanosterol 14 alpha-demethylase (CYP51) was investigated by molecular docking. The studies presented here provide a new structural type for the development of novel antifungal compounds. Furthermore, 10b was evaluated in vivo by a rat vaginal candidiasis model, and it was found that 10b significantly decreases the number of fungal colony counts.
• US3943172A
  申请人：——

  公开号：US3943172A

  公开（公告）日：1976-03-09
• US3984464A
  申请人：——

  公开号：US3984464A

  公开（公告）日：1976-10-05
• B(C₆F₅)₃-catalyzed metal-free hydrogenation of naphthylamines
  作者：Gen Li、Yongbing Liu、Haifeng Du

  DOI：10.1039/c5ob00009b

  日期：——

  A catalytic metal-free hydrogenation of naphthylamines using B(C6F5)3 as a catalyst was successfully achieved under mild conditions for the first time to furnish a variety of tetrahydronaphthylamines in 88–99% yields.

  使用B（C 6 F 5）3作为催化剂的萘胺的无催化金属氢化首次在温和条件下成功实现，以88-99％的产率提供了各种四氢萘胺。
• Derivatives of 2-amino-(1,2,3,4-tetrahydronaphthalene), the preparation
  申请人：A. Christiaens, Societe Anonyme

  公开号：US03943172A1

  公开（公告）日：1976-03-09

  This invention relates to new derivatives of 2-amino-(1,2,3,4-tetrahydronaphthalene), namely 2-[N-phenyl-N-(R.sub.1,R.sub.2 -aminoalkyl or alkanoyl)]-amino-(1,2,3,4-tetrahydronaphthalenes), in which R.sub.1 and R.sub.2 represent a lower alkyl group or form together with the attached nitrogen atom a nitrogenous heterocyclic ring, with the proviso that R.sub.1 may also represent hydrogen, as well as to the acid addition salts of these new derivatives. These new derivatives are active for the treatment of heart arrhythmy.

  本发明涉及2-氨基-(1,2,3,4-四氢萘)的新衍生物，即2-[N-苯基-N-(R.sub.1，R.sub.2-氨基烷基或酰基)]-氨基-(1,2,3,4-四氢萘)，其中R.sub.1和R.sub.2代表较低的烷基或与连接的氮原子一起形成含氮杂环，但R.sub.1也可能代表氢，以及这些新衍生物的酸加成盐。这些新衍生物对治疗心律失常有活性。