4-hydrazino-2-trifluoromethylquinazoline | 154136-31-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-hydrazino-2-trifluoromethylquinazoline
• 英文别名: (2-trifluoromethyl-quinazolin-4-yl)-hydrazine；4-Hydrazino-2-(trifluoromethyl)quinazoline；[2-(trifluoromethyl)quinazolin-4-yl]hydrazine
• CAS: 154136-31-9
• 化学式: C₉H₇F₃N₄
• mdl: MFCD00793693
• 分子量: 228.177
• InChiKey: OBZZCRXGECYMPR-UHFFFAOYSA-N

物化性质

• 熔点：
  258-261°
• 沸点：
  295.9±50.0 °C(Predicted)
• 密度：
  1.56±0.1 g/cm3(Predicted)
• 溶解度：
  19.4 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  63.8
• 氢给体数：
  2
• 氢受体数：
  7

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  柠康酸酐 、 4-hydrazino-2-trifluoromethylquinazoline 以 氯仿 为溶剂， 反应 12.0h， 生成 3-Methyl-1-[[2-(trifluoromethyl)quinazolin-4-yl]amino]pyrrole-2,5-dione
  参考文献：
  名称：

  The design and synthesis of novel orally active inhibitors of AP-1 and NF-κB mediated transcriptional activation. SAR of In vitro and In vivo studies

  摘要：

  We have developed novel orally active quinazoline analogues as inhibitors of AP-1 and NF-kappaB mediated transcriptional activation. Among the derivatives prepared, 1-[2-(2-thienyl)quinazolin-4-ylamino]-3-methyl-3-pyrroline-2,5-dione (10) showed significant activity in an adjuvant-induced arthritis rat model by reducing the swelling by 65% in the non-injected foot. The synthesis, structure-activity relationship, and in vivo activity are described. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.08.047
• 作为产物：
  描述：

  2-(三氟甲基)-3,1-苯并恶嗪-4-酮 在 ammonium acetate 、 肼 、 三氯氧磷 作用下， 以 四氢呋喃 为溶剂， 反应 11.0h， 生成 4-hydrazino-2-trifluoromethylquinazoline
  参考文献：
  名称：

  The design and synthesis of novel orally active inhibitors of AP-1 and NF-κB mediated transcriptional activation. SAR of In vitro and In vivo studies

  摘要：

  We have developed novel orally active quinazoline analogues as inhibitors of AP-1 and NF-kappaB mediated transcriptional activation. Among the derivatives prepared, 1-[2-(2-thienyl)quinazolin-4-ylamino]-3-methyl-3-pyrroline-2,5-dione (10) showed significant activity in an adjuvant-induced arthritis rat model by reducing the swelling by 65% in the non-injected foot. The synthesis, structure-activity relationship, and in vivo activity are described. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.08.047

文献信息

• [EN] QUINAZOLINE ANALOGS AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS<br/>[FR] ANALOGUES DE QUINAZOLINE ET COMPOSES ASSOCIES ET METHODES POUR TRAITER LES TROUBLES INFLAMMATOIRES
  申请人：SIGNAL PHARMACEUTICALS, INC.

  公开号：WO1999001441A1

  公开（公告）日：1999-01-14

  (EN) Compounds having utility as anti-inflammatory agents in general and, more specifically, for the prevention and/or treatment of immunoinflammatory and autoimmune diseases are disclosed. The compounds are quinazoline-containing compounds. Methods are also disclosed for preventing and/or treating inflammatory conditions by administering to an animal in need thereof an effective amount of a compound of this invention, preferably in the form of a pharmaceutical composition.(FR) L'invention concerne des composés utiles de manière générale comme agents anti-inflammatoires et plus spécifiquement comme agents préventifs et/ou thérapeutiques pour les maladies immuno-inflammatoires et auto-immunes. Ces composés contiennent de la quinazoline. L'invention concerne également de méthodes pour prévenir et/ou traiter les états inflammatoires en administrant à un animal nécessitant un tel traitement une quantité efficace d'un des composés décrits, de préférence sous forme d'une composition pharmaceutique.

  该发明涉及一种具有抗炎作用的化合物，可用于预防和/或治疗免疫炎症和自身免疫疾病。这些化合物含有喹唑啉。本发明还揭示了通过向需要治疗的动物施用本发明的化合物的有效量，尤其是以药物组成物的形式，以预防和/或治疗炎症状况的方法。
• Reagent for determination of hydrogen peroxide
  申请人：Okabe Kazuaki

  公开号：US20050130251A1

  公开（公告）日：2005-06-16

  A reagent for determination of hydrogen peroxide which comprises (A) a compound represented by the following general formula (I): R 1 —NH—R 2 (I) (wherein R 1 represents a carbamoyl group or the like, and R 2 represents an arylamino group, a heteroarylamino group, or a substituent represented by the following general formula (II): [wherein R 3 to R 6 represent X—Y—R a R a represents a hydrogen atom, an alkyl group or the like, X represents a single bond, O or the like, and Y represents a single bond, (C═O) or the like}, a cyano group, a halogen atom or the like]>; (B) a compound represented by the general formula (III): [wherein R 9 represents a group which can be eliminated by oxidative coupling color-developing reaction with the compound represented by the formula (I), and R 7 , R 8 , and R 10 to R 13 have the same meaning as that of R 3 ], or the like; and (C) a peroxidative substance.

  一种用于测定双氧水的试剂，包括（A）由下列通式（I）表示的化合物：R1—NH—R2（I）（其中，R1表示氨甲酰基或类似物，R2表示芳基氨基基团、杂芳基氨基基团或下列通式（II）表示的取代基：[其中R3至R6表示X—Y—RaRa表示氢原子、烷基或类似物，X表示单键、O或类似物，Y表示单键、（C═O）或类似物}、氰基、卤素原子或类似物]>；（B）由通式（III）表示的化合物：[其中R9表示可以通过氧化偶合显色反应与通式（I）表示的化合物发生消除的基团，R7、R8和R10至R13具有与R3相同的含义]或类似物；以及（C）过氧化物质。
• Photographic silver halide color material having incorporated therein a
  申请人：Eastman Kodak Company

  公开号：US05284739A1

  公开（公告）日：1994-02-08

  Photographic materials having incorporated sulphonyhdrazide color developing agents. Such photographic materials have at least two color-forming units, each of which has a silver halide emulsion layer and a photographic coupler. A ballasted heterocyclic sulphonhydrazide color developing agent is present in the material in droplets of a high boiling point solvent. A method of forming a photographic color image using such materials is also provided.

  含有磺酰肼类显色剂的摄影材料。这些摄影材料至少有两个形成颜色的单元，每个单元都有一层银卤化物乳剂层和一种摄影耦合剂。一种带有配基的杂环磺酰肼类显色剂存在于材料中，以高沸点溶剂的液滴形式出现。还提供了使用这种材料形成摄影彩色图像的方法。
• Antiproliferative Pyrimidyl, Fused Pyrimidyl and Pyrimidyl Hydrazones
  申请人：Healey Brian

  公开号：US20080287474A1

  公开（公告）日：2008-11-20

  The present invention is related to a novel series of pyrimidyl or fused pyrimidyl hydrazones. Compounds of Formula (I) wherein A is selected from the group consisting of Formulas (A1), (A2), (A3), (A4), (A5) are useful for the treatment and/or prevention of a proliferative disease.

  本发明涉及一种新型的嘧啶基或融合嘧啶基肼酮系列。式（I）的化合物，其中A选自公式（A1）、（A2）、（A3）、（A4）、（A5）的群组，对于治疗和/或预防增生性疾病是有用的。
• Antiproliferative pyrimidyl, fused pyrimidyl and pyrimidyl hydrazones
  申请人：Merck Serono SA

  公开号：US08288398B2

  公开（公告）日：2012-10-16

  The present invention is related to a novel series of pyrimidyl or fused pyrimidyl hydrazones. Compounds of Formula (I) wherein A is selected from the group consisting of Formulas (A1), (A2), (A3), (A4), (A5) are useful for the treatment and/or prevention of a proliferative disease.

  本发明涉及一种新型的嘧啶基或融合嘧啶基腙类化合物系列。式(I)中，A选自公式(A1)、(A2)、(A3)、(A4)、(A5)组成的群，有用于治疗和/或预防增生性疾病的作用。