(-)-4-(2,4-dichlorophenyl)-5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphorinane 2-oxide | 98634-30-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (-)-4-(2,4-dichlorophenyl)-5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphorinane 2-oxide
• 英文别名: (-)-2,4-dichlocyphos；4-(2,4-Dichlorophenyl)-2-hydroxy-5,5-dimethyl-1,3,2lambda5-dioxaphosphinane 2-oxide；4-(2,4-dichlorophenyl)-2-hydroxy-5,5-dimethyl-1,3,2λ5-dioxaphosphinane 2-oxide
• CAS: 98634-30-1；98674-90-9；98674-91-0；149113-54-2
• 化学式: C₁₁H₁₃Cl₂O₄P
• 分子量: 311.102
• InChiKey: QRNLZDKAPOJMQB-UHFFFAOYSA-N

物化性质

• 沸点：
  382.8±52.0 °C(Predicted)
• 密度：
  1.46±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (1S,2S)-2-甲氨基-1-苯基丙-1-醇 、 (-)-4-(2,4-dichlorophenyl)-5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphorinane 2-oxide 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Haest, A. D. van der; Wynberg, H.; Leusen, F. J. J., Recueil des Travaux Chimiques des Pays-Bas, 1990, vol. 109, # 10, p. 523 - 528

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4-二氯苯甲醛 在 氢氧化钾 、 sodium hydroxide 、 三乙胺 、 三氯氧磷 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 8.25h， 生成 (-)-4-(2,4-dichlorophenyl)-5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphorinane 2-oxide
  参考文献：
  名称：

  The design of resolving agents. Chiral cyclic phosphoric acids

  摘要：

  DOI：

  10.1021/jo00223a018

文献信息

• Process for preparing optically active 2,3-dihydrobenzofuran compounds
  申请人：——

  公开号：US20040077712A1

  公开（公告）日：2004-04-22

  A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: 1 [wherein R 1 and R 2 are each hydrogen or an optionally substituted hydrocarbon group; R 3 is an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.

  一种制备光学活性2,3-二氢苯并呋喃化合物的方法，包括将一般式所表示的2,3-二氢苯并呋喃化合物或其盐与光学活性酸化合物进行光学分辨：1 [其中R1和R2均为氢或可选取代的碳氢基团；R3为可选取代的芳香基团；C为苯环，除氨基外还可能有取代基]。该方法可实现工业上优势的中间体生产，用于合成对神经退行性疾病等有预防和/或治疗作用的光学活性2,3-二氢苯并呋喃化合物。
• Process for producing benzofuran derivative
  申请人：——

  公开号：US20040210066A1

  公开（公告）日：2004-10-21

  A novel process for efficiently and easily producing a compound represented by the formula: 1 wherein ring A is a benzene ring that may be optionally further substituted in addition to the group represented by W, or a salt thereof; which comprises reacting a compound represented by the formula: 2 wherein R 1 and R 2 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, Y is a halogen atom, ring A is a benzene ring that may be optionally further substituted in addition to the group represented by Y and ring B is an optionally substituted benzene ring, or a salt thereof, with a compound represented by the formula: WH wherein W is 3 wherein ring C is an optionally substituted benzene ring, ring D is an optionally substituted 5- to 7-membered nitrogen-containing heterocyclic ring, R 3 is a hydrogen atom, an aliphatic hydrocarbon group containing an aromatic group or an acyl group, and R 4 is a hydrogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof and thereafter, if necessary, deprotecting the resultant product, which is suitable for industrial production.

  一种高效且容易生产化合物的新工艺，该化合物的分子式为1，其中环A是苯环，除了W基团外还可以选择进一步取代，或其盐。该工艺包括将分子式为2的化合物与分子式为WH的化合物反应，其中R1和R2相同或不同，每个都是氢原子，可选择取代的碳氢基团或可选择取代的杂环基团，Y是卤素原子，环A是苯环，除了Y基团外还可以选择进一步取代，环B是可选择取代的苯环，或其盐。分子式为WH的化合物中，W是3，其中环C是可选择取代的苯环，环D是可选择取代的5-至7-成员含氮杂环，R3是氢原子，含芳香基团的脂肪烃基团或酰基，R4是氢原子，可选择取代的碳氢基团或酰基，或其盐。然后，必要时去保护所得产物，该产物适用于工业生产。
• Azo Compounds and Process for Production Thereof
  申请人：Ikemoto Tomomi

  公开号：US20080009539A1

  公开（公告）日：2008-01-10

  A process for the production of an aromatic azo compound having a 2,3-dihydrobenzofuran ring bearing a diazo group at the 5-position of the ring by conducting the diazo coupling of a 2,3-dihydrobenzofuran derivative represented by the general formula (II): [wherein R 1 and R 2 are each independently C 1-6 alkyl; R 3 is optionally substituted aryl; and R 4 , R 5 and R 6 are each independently hydrogen, C 1-6 alkyl, halogeno, C 1-6 alkoxy, or C 1-6 alkylthio] with a benzenediazonium salt having an electron-withdrawing group at the p- and/or o-position in a mixed solvent composed of water and a polar organic solvent.

  一种制备含有2,3-二氢苯并呋喃环，在环上的5位带有重氮基团的芳香偶氮化合物的方法，通过在由水和极性有机溶剂组成的混合溶剂中，将通式（II）所代表的2,3-二氢苯并呋喃衍生物[其中R1和R2各自独立地是C1-6烷基；R3是可选的取代芳基；R4、R5和R6各自独立地是氢、C1-6烷基、卤素、C1-6烷氧基或C1-6烷硫基]与在p-位和/或o-位具有电子吸引基团的苯基重氮盐进行重氮偶联反应。
• PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE CYCLIC ENAMINONE DERIVATIVES
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1229019A1

  公开（公告）日：2002-08-07

  A process for the production of optically active cyclic enaminone derivatives characterized by aminating one of the carbonyl groups of a cyclic 1,3-diketone derivative having a symmetry plane to obtain an optically isomeric mixture of chiral cyclic enaminone derivatives and subjecting this mixture to optical resolution.

  一种生产光学活性环烯丙酮衍生物的工艺，其特征在于将具有对称平面的环 1，3-二酮衍生物的一个羰基胺化，得到手性环烯丙酮衍生物的光学异构体混合物，并对该混合物进行光学解析。
• PROCESS FOR PREPARING OPTICALLY ACTIVE 2,3-DIHYDRO- BENZOFURAN COMPOUNDS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1346988A1

  公开（公告）日：2003-09-24

  A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: [wherein R1 and R2 are each hydrogen or an optionally substituted hydrocarbon group; R3 is an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.

  一种制备光学活性 2，3-二氢苯并呋喃化合物的工艺，包括将通式所代表的 2，3-二氢苯并呋喃化合物或其盐与光学活性酸化合物进行光学解析： [其中 R1 和 R2 分别为氢或任选取代的烃基；R3 为任选取代的芳香族基团；C 为苯环，除氨基外还可进一步具有取代基]。该工艺可生产出具有工业优势的中间体，用于合成具有光学活性的 2,3-二氢苯并呋喃化合物，这些化合物可作为神经退行性疾病等的预防和/或治疗药物。