2-[2-[2-[2-[2-[2-[2-(1,3-Dioxoisoindol-2-yl)oxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]isoindole-1,3-dione | 894414-81-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-[2-[2-[2-[2-[2-[2-(1,3-Dioxoisoindol-2-yl)oxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]isoindole-1,3-dione
• CAS: 894414-81-4
• 化学式: C₂₈H₃₂N₂O₁₁
• 分子量: 572.569
• InChiKey: MXHYWALCCFYJRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  41
• 可旋转键数：
  20
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  139
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  2-[2-[2-[2-[2-[2-[2-(1,3-Dioxoisoindol-2-yl)oxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]isoindole-1,3-dione 在 氨 作用下， 以 甲醇 为溶剂， 反应 15.0h， 以87%的产率得到氨氧基-五聚乙二醇-氨氧基
  参考文献：
  名称：

  COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES

  摘要：

  公开号：

  EP1828224B1
• 作为产物：
  描述：

  N-羟基邻苯二甲酰亚胺 、 六甘醇 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以77%的产率得到2-[2-[2-[2-[2-[2-[2-(1,3-Dioxoisoindol-2-yl)oxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]isoindole-1,3-dione
  参考文献：
  名称：

  WO2008/83346

  摘要：

  公开号：

文献信息

• Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
  申请人：Ambrx, Inc.

  公开号：EP2399893A2

  公开（公告）日：2011-12-28

  Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oximine, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

  本文公开了非天然氨基酸和包括至少一种非天然氨基酸的多肽，以及制造这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分，可包括多种可能的官能团，但典型的至少有一个肟基、羰基、二羰基和/或羟胺基。本文还公开了经翻译后进一步修饰的非天然氨基酸多肽、进行此类修饰的方法以及纯化此类多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟基、羰基、二羰基和/或羟胺基团。进一步公开的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗、诊断和其它生物技术用途。
• Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides
  申请人：MIAO Zhenwei

  公开号：US20080177027A1

  公开（公告）日：2008-07-24

  Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
• US7332571B2
  申请人：——

  公开号：US7332571B2

  公开（公告）日：2008-02-19
• US7385028B2
  申请人：——

  公开号：US7385028B2

  公开（公告）日：2008-06-10
• US7638491B2
  申请人：——

  公开号：US7638491B2

  公开（公告）日：2009-12-29