pregnanediol-3α-glucuronide | 38055-17-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: pregnanediol-3α-glucuronide
• 英文别名: pregnanediol glucuronide；O¹-(20α_F-hydroxy-5β-pregnan-3α-yl)-β-D-glucopyranuronic acid；O¹-(20α_F-Hydroxy-5β-pregnan-3α-yl)-β-D-glucopyranuronsaeure；Pregnanediol-3-glucuronide；(2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[[(3R,5R,8R,9S,10S,13S,14S,17S)-17-[(1S)-1-hydroxyethyl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxane-2-carboxylic acid
• CAS: 38055-17-3
• 化学式: C₂₇H₄₄O₈
• mdl: MFCD00056522
• 分子量: 496.642
• InChiKey: ZFFFJLDTCLJDHL-JQYCEVDMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.962
• 拓扑面积：
  137
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 乙酸酐 、 pregnanediol-3α-glucuronide 在 乙醇 、 sodium acetate 作用下， 生成 O¹-(20α_F-acetoxy-5β-pregnan-3α-yl)-O²,O³,O⁴-triacetyl-β-D-glucopyranuronic acid methyl ester
  参考文献：
  名称：

  Huebner et al., Journal of Biological Chemistry, 1944, vol. 155, p. 615

  摘要：

  DOI：
• 作为产物：
  描述：

  乙酰溴-Alpha-D-葡萄糖酮酸甲基酯 在 sodium hydroxide 、 silver(l) oxide 、 苯 作用下， 生成 pregnanediol-3α-glucuronide
  参考文献：
  名称：

  Huebner et al., Journal of Biological Chemistry, 1944, vol. 155, p. 615

  摘要：

  DOI：

文献信息

• Norymberski; Sermin, Biochemical Journal, 1953, vol. 55, p. 876,877
  作者：Norymberski、Sermin

  DOI：——

  日期：——
• METHOD AND APPARATUS FOR A PREGNANEDIOL URINE ASSAY
  申请人：MFB Fertility, Inc.

  公开号：US20210055310A1

  公开（公告）日：2021-02-25

  An in-home lateral flow assay test strip that can be used to monitor PdG levels in urine, which correlate with progesterone levels in serum. The lateral flow test strip is a competitive assay comprising a sample pad, conjugate pad, membrane strip, backing card, an adsorbent pad, a test line impregnated onto the membrane strip comprised of pregnanediol glucuronide (PdG) conjugated to immunoglobulin G (IgG), bovine serum albumin (BSA), bovine gamma globulin (BGG) or another suitable carrier protein and a control line impregnated onto the membrane strip comprised of anti-mouse antibodies. The conjugate pad is saturated with mouse monoclonal anti-PdG antibodies conjugated to colloidal gold, latex beads, or similar visual dye. The test strip may be encased in a cassette such that only the wicking pad and detection zone are visible to the user.
• Huebner et al., Journal of Biological Chemistry, 1944, vol. 155, p. 615
  作者：Huebner et al.

  DOI：——

  日期：——