4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-(dimethyl-λ4-sulfanylidene)-1-naphthalenecarboxamide | 1092708-30-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-(dimethyl-λ4-sulfanylidene)-1-naphthalenecarboxamide
• 英文别名: 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isooxazolyl]-N-(dimethyl-λ4-thioxo)-1-naphthalenecarboxamide；4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-(dimethyl-lambda4-sulfanylidene)-1-naphthalenecarboxamide；4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-N-(dimethyl-λ4-sulfanylidene)naphthalene-1-carboxamide
• CAS: 1092708-30-9
• 化学式: C₂₃H₁₇Cl₂F₃N₂O₂S
• 分子量: 513.367
• InChiKey: PMTTXMGRSLYNMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  70.2
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-1-naphthalenecarboxamide 、 二甲基亚砜 在 三氟乙酸酐 作用下， 以 二氯甲烷 为溶剂， 反应 1.17h， 以82%的产率得到4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-(dimethyl-λ4-sulfanylidene)-1-naphthalenecarboxamide
  参考文献：
  名称：

  WO2008/154528

  摘要：

  公开号：

文献信息

• ISOXAZOLINE INSECTICIDES
  申请人：Lahm George Philip

  公开号：US20100179195A1

  公开（公告）日：2010-07-15

  Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A is a 6-membered aromatic ring containing carbon atoms and 0-3 nitrogen atoms as ring members, said ring optionally substituted with 1-5 substituents independently selected from R 2 ; R 1 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, C 4 -C 7 alkylcycloalkyl or C 4 -C 7 cycloalkylalkyl, each optionally substituted with one or more substituents independently selected from R 21 ; R 21 is independently H, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio, C 1 -C 6 haloalkylthio, C 1 -C 6 alkylsulfinyl, C 1 -C 6 haloalkylsulfinyl, C 1 -C 6 alkylsulfonyl, C 1 -C 6 haloalkylsulfonyl, CN or NO 2 ; and Q is as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

  本发明公开了Formula 1化合物，包括其所有的构型和立体异构体、N-氧化物和盐，其中A是一个6元芳香环，包含碳原子和0-3个氮原子作为环成员，该环可选地被1-5个独立选择的R2取代基取代；R1是C1-C6烷基、C2-C6烯基、C2-C6炔基、C3-C6环烷基、C4-C7烷基环烷基或C4-C7环烷基烷基，每个基可选地被一个或多个独立选择的R21取代基取代；R21独立地是氢、卤素、C1-C6烷基、C1-C6烷氧基、C1-C6卤代烷氧基、C1-C6烷基硫醇、C1-C6卤代烷基硫醇、C1-C6烷基亚砜、C1-C6卤代烷基亚砜、C1-C6烷基磺酰基、C1-C6卤代烷基磺酰基、CN或NO2；Q如本公开所定义。本发明还公开了含有Formula 1化合物的组合物以及使用本发明的化合物或组合物的生物有效量接触无脊椎动物害虫或其环境以控制无脊椎动物害虫的方法。
• Isoxazoline insecticides
  申请人：Lahm George Philip

  公开号：US08623875B2

  公开（公告）日：2014-01-07

  Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A is a 6-membered aromatic ring containing carbon atoms and 0-3 nitrogen atoms as ring members, said ring optionally substituted with 1-5 substituents independently selected from R2; R1 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C7 alkylcycloalkyl or C4-C7 cycloalkylalkyl, each optionally substituted with one or more substituents independently selected from R21; R21 is independently H, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, CN or NO2; and Q is as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

  本发明涉及公式1的化合物，包括其所有的几何和立体异构体、N-氧化物和盐，其中A为6元芳香环，包含碳原子和0-3个氮原子作为环成员，该环可选择地用1-5个独立选择的R2取代基取代；R1为C1-C6烷基、C2-C6烯基、C2-C6炔基、C3-C6环烷基、C4-C7烷基环烷基或C4-C7环烷基烷基，每个基可选择地用一个或多个独立选择的R21取代基取代；R21独立地为H、卤素、C1-C6烷基、C1-C6烷氧基、C1-C6卤代烷氧基、C1-C6烷硫基、C1-C6卤代烷硫基、C1-C6烷基亚磺酰基、C1-C6卤代烷基亚磺酰基、C1-C6烷基磺酰基、C1-C6卤代烷基磺酰基、CN或NO2；Q如本文所述。本发明还涉及包含公式1化合物的组合物和用化合物或本发明组合物的生物学有效量与无脊椎动物害虫或其环境接触以控制无脊椎动物害虫的方法。
• US8623875B2
  申请人：——

  公开号：US8623875B2

  公开（公告）日：2014-01-07
• US9095138B2
  申请人：——

  公开号：US9095138B2

  公开（公告）日：2015-08-04