methyl 7-chloro-4-methyl-4H-imidazo[4,5-d]thiazolo[5,4-b]-pyridine-2-carboxylate | 805320-62-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: methyl 7-chloro-4-methyl-4H-imidazo[4,5-d]thiazolo[5,4-b]-pyridine-2-carboxylate
• 英文别名: 8-methyl-5-chloro-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxylic acid methyl ester；Methyl 8-chloro-12-methyl-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1,3,6,8,10-pentaene-4-carboxylate
• CAS: 805320-62-1
• 化学式: C₁₀H₇ClN₄O₂S
• 分子量: 282.71
• InChiKey: BKQKTAPAKKUCIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  98.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  methyl 7-chloro-4-methyl-4H-imidazo[4,5-d]thiazolo[5,4-b]-pyridine-2-carboxylate 在 sodium hydroxide 、 水 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 以53%的产率得到7-chloro-4-methyl-4H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxylic acid
  参考文献：
  名称：

  [EN] OXAZOLYL - AND THIAZOLYL - PURINE BASED TRICYCLIC COMPOUNDS.
  [FR] COMPOSES TRICYCLIQUES A BASE D'OXAZOLO[4,5-B]PYRIDINE CONDENSEE A UN IMIDAZO ET DE THIAZOLO[4,5-B]PYRIDINE CONDENSEE A UN IMIDAZO, ET COMPOSITIONS PHARMACEUTIQUES RENFERMANT CEUX-CI

  摘要：

  公开号：

  WO2004106293A3
• 作为产物：
  描述：

  甲醇 、 7-chloro-4-methyl-2-bromo-4H-imidazo[4,5-d]thiazolo[5,4-b]-pyridine 、 一氧化碳 在 bis-triphenylphosphine-palladium(II) chloride 、 三乙胺 作用下， 以 乙腈 为溶剂， 60.0 ℃ 、689.49 kPa 条件下， 反应 24.0h， 以91%的产率得到methyl 7-chloro-4-methyl-4H-imidazo[4,5-d]thiazolo[5,4-b]-pyridine-2-carboxylate
  参考文献：
  名称：

  Novel Tricyclic Inhibitors of IκB Kinase

  摘要：

  The design and synthesis of a novel series of oxazole-, thiazole-, and imidazole-based inhibitors of I kappa B kinase (IKK) are reported. Biological activity was improved compared to the pyrazolopurine lead, and the expedient synthesis of the new tricyclic systems allowed for efficient exploration of structure-activity relationships. This, combined with an iterative rat cassette dosing strategy, was used to identify compounds with improved pharmacokinetic (PK) profiles to advance for in vivo evaluation.

  DOI：

  10.1021/jm8015816

文献信息

• Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
  申请人：Pitts J. William

  公开号：US20060217412A1

  公开（公告）日：2006-09-28

  The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.

  本发明提供了具有式(I)的嘧唑并咪唑基三环化合物，其中R1、R2、R3、R4、R5和R6如本文所述。本发明还提供了包含这些化合物的制药组合物，以及使用这些化合物治疗炎症和免疫性疾病的方法。
• Imidazo-fused oxazolo[4,5-beta]pyridine and imidazo-fused thiazolo[4,5-beta]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
  申请人：Pitts J. William

  公开号：US20050101626A1

  公开（公告）日：2005-05-12

  The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.

  本发明提供了具有式（I）的吡唑嘌呤基三环化合物、 其中 R 1 , R 2 , R 3 , R 4 , R 5 和 R 6 如本文所述。本发明进一步提供了包含此类化合物的药物组合物，以及使用此类化合物治疗炎症和免疫疾病的方法。
• US7176214B2
  申请人：——

  公开号：US7176214B2

  公开（公告）日：2007-02-13
• [EN] OXAZOLYL - AND THIAZOLYL - PURINE BASED TRICYCLIC COMPOUNDS.<br/>[FR] COMPOSES TRICYCLIQUES A BASE D'OXAZOLO[4,5-B]PYRIDINE CONDENSEE A UN IMIDAZO ET DE THIAZOLO[4,5-B]PYRIDINE CONDENSEE A UN IMIDAZO, ET COMPOSITIONS PHARMACEUTIQUES RENFERMANT CEUX-CI
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2004106293A3

  公开（公告）日：2005-03-24
• Novel Tricyclic Inhibitors of IκB Kinase
  作者：James Kempson、Steven H. Spergel、Junqing Guo、Claude Quesnelle、Patrice Gill、Dominique Belanger、Alaric J. Dyckman、Tianle Li、Scott H. Watterson、Charles M. Langevine、Jagabandhu Das、Robert V. Moquin、Joseph A. Furch、Anne Marinier、Marco Dodier、Alain Martel、David Nirschl、Katy Van Kirk、James R. Burke、Mark A. Pattoli、Kathleen Gillooly、Kim W. McIntyre、Laishun Chen、Zheng Yang、Punit H. Marathe、David Wang-Iverson、John H. Dodd、Murray McKinnon、Joel C. Barrish、William J. Pitts

  DOI：10.1021/jm8015816

  日期：2009.4.9

  The design and synthesis of a novel series of oxazole-, thiazole-, and imidazole-based inhibitors of I kappa B kinase (IKK) are reported. Biological activity was improved compared to the pyrazolopurine lead, and the expedient synthesis of the new tricyclic systems allowed for efficient exploration of structure-activity relationships. This, combined with an iterative rat cassette dosing strategy, was used to identify compounds with improved pharmacokinetic (PK) profiles to advance for in vivo evaluation.