Phenol, 2,6-bis[bis(2-pyridinylmethyl)amino]-4-(1,1-dimethylethyl)- | 548756-41-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phenol, 2,6-bis[bis(2-pyridinylmethyl)amino]-4-(1,1-dimethylethyl)-
• 英文别名: 2,6-bis[bis(pyridin-2-ylmethyl)amino]-4-tert-butylphenol
• CAS: 548756-41-8
• 化学式: C₃₄H₃₆N₆O
• 分子量: 544.699
• InChiKey: FRDRWEFSJIZJTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  41
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  78.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Phenol, 2,6-bis[bis(2-pyridinylmethyl)amino]-4-(1,1-dimethylethyl)- 、 tetrakis(acetonitrile)copper(I) 以 not given 为溶剂， 生成
  参考文献：
  名称：

  Exogenous Nitrile Substrate Hydroxylation by a New Dicopper-Hydroperoxide Complex

  摘要：

  A dicopper(I)/phenol-ligand complex in RCN solvents reacts with O2 producing a mu-1,1-hydroperoxo dicopper(II) species. Subsequent thermal transformation results in nitrile hydroxylation and elimination of cyanide, as revealed by the isolation in comparable yields of (i) a cyanide-bridged tetranuclear cluster complex and (ii) benzaldehyde (for R = PhCH2); 18O labeling confirms that the PhC(O)H oxygen atom derives from O2.

  DOI：

  10.1021/ja054948a

文献信息

• Targeted Guanine Oxidation by a Dinuclear Copper(II) Complex at Single Stranded/Double Stranded DNA Junctions
  作者：Lei Li、Narasimha N. Murthy、Joshua Telser、Lev. N. Zakharov、Glenn P. A. Yap、Arnold L. Rheingold、Kenneth D. Karlin、Steven E. Rokita

  DOI：10.1021/ic0605930

  日期：2006.9.1

  dinuclear copper(II) complex [Cu(II)2(PD'O-)(H2O)2](ClO4)3 (5) with terminal Cu(II)-H(2)O moieties and a Cu...Cu distance of 4.13 A (X-ray structure) has been synthesized and characterized by EPR spectroscopy (ferromagnetic coupling observed) and cyclic voltammetry. Dizinc(II) and mononuclear copper(II) analogues [Zn(II)2(PD'O-)(H2O)2]3+ (7) and [Cu(II)(mPD'OH)(H2O)]2+ (6), respectively, have also been

  双核铜（II）络合物[Cu（II）2（PD'O-）（H2O）2]（ClO4）3（5），带有末端Cu（II）-H（2）O部分和Cu ...合成了4.13 A（X射线结构）的Cu距离，并通过EPR光谱（观察到铁磁耦合）和循环伏安法对其进行了表征。二锌（II）和单核铜（II）类似物[Zn（II）2（PD'O-）（ ）2] 3+（7）和[Cu（II）（mPD'OH）（ ）] 2+ （6）分别也已经合成和结构表征。与DNA反应5 / MPA / O（2）（MPA = 3-巯基丙酸）会导致在单链和双链DNA之间的连接处鸟嘌呤（G）发生高度特异性的氧化。主要产物的质谱分析表明，相对于初始DNA链，获得了+18和+34 amu的增益。最有效的反应需要在从连接处延伸的每条链的第一和第二个未配对位置处具有G。对于类似的靶标，其中G簇离连接点更远或包含少于四个Gs，观察到的反应较少。与我们以前的系统一致
• SENSORS FOR DETECTION OF NEGATIVELY CHARGED PHOSPHATE-CONTAINING MEMBRANES AND MEMBRANE COMPONENTS
  申请人：THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

  公开号：US20200270218A1

  公开（公告）日：2020-08-27

  This application relates to a method of detecting negatively charged phosphate-containing membranes and membrane components, such as in cell membranes or artificial lipid vesicles, and its use, for example, in detecting apoptosis and bacterial infection.
• US2005/148662
  申请人：——

  公开号：——

  公开（公告）日：——