alpha-lipoic acid 4-hydroxybenzophenone ester | 1400582-67-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: alpha-lipoic acid 4-hydroxybenzophenone ester
• 英文别名: (4-Benzoylphenyl) 5-(dithiolan-3-yl)pentanoate；(4-benzoylphenyl) 5-(dithiolan-3-yl)pentanoate
• CAS: 1400582-67-3
• 化学式: C₂₁H₂₂O₃S₂
• 分子量: 386.536
• InChiKey: OODHUQKFXREFNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  94
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-羟基-二苯甲酮 、 Thioctic acid 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 alpha-lipoic acid 4-hydroxybenzophenone ester
  参考文献：
  名称：

  抗菌和与细胞相容的表面附着聚合物网络-化学结构与物理和生物学数据的相关性如何导致作用机理的改变。

  摘要：

  我们提出了一种基于光诱导硫醇-烯化学的合成平台，通过该平台可以轻松地获得抗菌聚氧氧冰片烯的表面附着网络（所谓的抗菌肽的聚合物合成模拟物，SMAMPs）。通过系统地改变疏水性和电荷密度，获得了具有高抗菌活性和出色的细胞相容性的表面附着的聚合物网络。对于具有恒定电荷密度的均聚物网络，随着疏水性的增加（即降低的可溶胀性和表观表面能），抗菌活性会系统地提高。无论电荷密度如何，所有网络的抗菌活性均与酸常数pK和等电点（IEP）相关-pK和IEP越低，抗菌活性就越高。网络的细胞相容性随可溶胀性和表观表面能的增加而增加，而随电荷密度的增加而降低。数据证实了抗微生物聚合物表面的作用机理取决于至少两个机械步骤，其中一个是疏水性驱动的，另一个与电荷有关。因此，我们建议采用电荷驱动和疏水驱动步骤的改进的机械模型。对于仅在疏水性上变化的抗菌网络，表面和溶液中的抗菌活性也相关-溶液中的活性越高，表面上的活性就越高。

  DOI：

  10.1039/c5tb00906e

文献信息

• It takes walls and knights to defend a castle – synthesis of surface coatings from antimicrobial and antibiofouling polymers
  作者：Peng Zou、Wibke Hartleb、Karen Lienkamp

  DOI：10.1039/c2jm31695a

  日期：——

  The synthesis and characterization of a bifunctional material containing antimicrobial and antibiofouling components is presented. An end-functionalized antibiofouling poly(oxonorbornene)-based poly(zwitterion) was synthesized and grafted onto a surface-immobilized network of an antimicrobial poly(oxonorbornene), which is in this case a cationic synthetic mimic of an antimicrobial peptide (SMAMP). The resulting material was characterized by Fourier-transform infrared spectroscopy, ellipsometry, atomic force microscopy and surface plasmon resonance spectroscopy (SPR). The SPR data indicate that this bifunctional material is antibiofouling in spite of the underlying cationic SMAMP carpet, and as such it might be a promising material with potentially two lines of defense against biofilm formation.

  本文介绍了一种含有抗菌和抗生物污染成分的双功能材料的合成和特性。合成了一种端部官能化的抗生物污染聚（氧降冰片烯）基聚（齐聚物），并将其接枝到抗菌聚（氧降冰片烯）的表面固定网络上，在本例中，抗菌聚（氧降冰片烯）是抗菌肽的阳离子合成模拟物（SMAMP）。傅立叶变换红外光谱仪、椭偏仪、原子力显微镜和表面等离子体共振光谱仪（SPR）对所制备的材料进行了表征。SPR 数据表明，尽管底层是阳离子 SMAMP 地毯，但这种双功能材料仍具有抗生物污垢的作用，因此它可能是一种具有双道防线防止生物膜形成的有前途的材料。
• Synthesis and micro-/nanostructuring of surface-attached crosslinked antimicrobial and/or antibiofouling polymer networks
  申请人：Universitätsklinikum Freiburg

  公开号：EP2636693A1

  公开（公告）日：2013-09-11

  The present invention relates to substrates comprising a crosslinked network of covalently attached antimicrobial and/or antibiofouling polymers. The crosslinked network of antimicrobial and/or antibiofouling polymers acts highly efficiently against pathogens, e.g. bacteria and fungi. Both the antimicrobial and the antibiofouling cross-linked polymer networks are preferably better resistant to mechanical damage than simple surface-immobilized polymer monolayers. The antimicrobial and/or antibiofouling polymers of the crosslinked network are preferably obtained by ring opening metathesis polymerization (ROMP) and exhibit a molecular weight of more than 1,000 g mol-1, preferably of more than 10,000 or even 100,000 g mol-1. The crosslinked network of antimicrobial and/or antibiofouling polymers is preferably covalently attached to the surface of a substrate, e.g. an implant, a medical device, medical equipment or a (tissue-supporting) biomaterial, etc. The present invention is also directed to uses of crosslinked networks of antimicrobial and/or antibiofouling polymers as defined herein, e.g. for coating a surface of a substrate, and to methods therefore.

  本发明涉及由共价连接的抗菌和/或防污聚合物交联网络组成的基材。交联的抗菌和/或防污聚合物网络可高效对抗细菌和真菌等病原体。与简单的表面固定聚合物单层相比，抗菌和抗生物污染交联聚合物网络具有更好的抗机械损伤能力。交联网络中的抗菌和/或防污聚合物最好是通过开环偏析聚合（ROMP）获得，分子量大于 1,000 g mol-1，最好大于 10,000 或甚至 100,000 g mol-1。抗微生物和/或抗生物污染聚合物的交联网络最好共价连接到基质表面，例如植入物、医疗器械、医疗设备或（组织支撑）生物材料等。本发明还涉及本文定义的抗微生物和/或抗生物污垢聚合物交联网络的用途，例如用于基底表面涂层，以及相关方法。
• METHOD FOR AN ANALYTE SENSOR COVER-MEMBRANE PREPARATION
  申请人：Roche Diabetes Care GmbH

  公开号：EP3735903A1

  公开（公告）日：2020-11-11

  The present invention relates to a process for forming a membrane on an analyte sensor. The present invention further relates to an analyte sensor obtainable by this process. Furthermore, the present invention relates to a process for forming a sensing layer on an electrode of an analyte sensor and to an analyte sensor comprising the sensing layer obtainable by the inventive process as well as the membrane obtainable by the inventive process. The analyte sensors obtainable by the inventive processes may mainly be used for conducting at least one analyte measurement of a bodily fluid of a user or a patient. The invention may both be applied in the field of home care as well as in the field of professional care, such as in hospitals. Other applications are generally feasible.

  本发明涉及一种在分析物传感器上形成膜的工艺。本发明还涉及一种可通过该工艺获得的被分析物传感器。此外，本发明还涉及一种在被分析物传感器的电极上形成传感层的工艺，以及一种包括通过本发明工艺获得的传感层和通过本发明工艺获得的膜的被分析物传感器。通过本发明工艺获得的分析物传感器主要用于对使用者或病人的体液进行至少一种分析物测量。本发明既可应用于家庭护理领域，也可应用于专业护理领域，如医院。其他应用一般也是可行的。
• Polymer having antimicrobial and/or antifouling properties
  申请人：ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG

  公开号：US10889726B2

  公开（公告）日：2021-01-12

  The present invention provides a polymer having antimicrobial and/or antifouling (protein-repellent) properties, a monomer that can be used in a method of producing the polymer of the invention, and a use of the polymer of the invention, including a method for coating the surface of a material, substrate or product with the polymer of the invention, as well as to products comprising the polymer of the invention and/or a coating comprising the polymer of the invention.

  本发明提供了一种具有抗菌和/或防污（驱蛋白）特性的聚合物，一种可用于生产本发明聚合物的方法的单体，以及本发明聚合物的用途，包括用本发明聚合物涂覆材料、基材或产品表面的方法，以及包含本发明聚合物的产品和/或包含本发明聚合物的涂层。
• [EN] A SIMULTANEOUSLY ANTIMICROBIAL AND PROTEIN-REPELLENT POLYZWITTERION<br/>[FR] POLYZWITTERION À LA FOIS ANTIMICROBIEN ET RÉPULSIF VIS-À-VIS DES PROTÉINES
  申请人：UNIV FREIBURG ALBERT LUDWIGS

  公开号：WO2018091467A3

  公开（公告）日：2018-07-12