3-(chloromethyl)-5-methylaniline | 1261775-24-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(chloromethyl)-5-methylaniline
• 英文别名: 3-(Chloromethyl)-5-methylaniline
• CAS: 1261775-24-9
• 化学式: C₈H₁₀ClN
• 分子量: 155.627
• InChiKey: GHIISILIMDBKDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-氨基-5-甲基苄醇 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 生成 3-(chloromethyl)-5-methylaniline
  参考文献：
  名称：

  [EN] 4-ARYL-N-PHENYL-1,3,5-TRIAZIN-2-AMINES CONTAINING A SULFOXIMINE GROUP
  [FR] 4-ARYL-N-PHÉNYL-1,3,5-TRIAZINE-2-AMINES CONTENANT UN GROUPE SULFOXIMINE

  摘要：

  本发明涉及一种含有一般式(I)或(Ia)中所述和定义的亚砜基团的4-芳基-N-苯基-1,3,5-三嗪-2-胺，以及它们的制备方法，它们用于治疗和/或预防疾病，特别是高增殖性疾病和/或病毒诱导的传染病和/或心血管疾病。该发明还涉及在制备所述一般式(I)或(Ia)化合物中有用的中间化合物。

  公开号：

  WO2012160034A1

文献信息

• [EN] DISUBSTITUTED 5-FLUORO PYRIMIDINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP<br/>[FR] DÉRIVÉS DE 5-FLUOROPYRIMIDINE DISUBSTITUÉS CONTENANT UN GROUPE SULFOXIMINE
  申请人：BAYER IP GMBH

  公开号：WO2013037894A1

  公开（公告）日：2013-03-21

  The present invention relates to disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

  本发明涉及含有一种磺氧亚胺基团的二取代5-氟嘧啶衍生物，其一般式（I）如本文所述和定义，并且涉及其制备方法，以及用于治疗和/或预防疾病，特别是高增殖性疾病和/或病毒诱导的传染病和/或心血管疾病的用途。该发明还涉及在制备上述一般式（I）化合物中有用的中间化合物。
• [EN] 4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFOXIMINE GROUP<br/>[FR] 4-(ORTHO)-FLUOROPHÉNYL)-5-FLUOROPYRIMIDIN-2-YL AMINES CONTENANT UN GROUPE SULFOXIMINE
  申请人：BAYER PHARMA AG

  公开号：WO2014076028A1

  公开（公告）日：2014-05-22

  The present invention relates to 4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

  本发明涉及一种含有一般式（I）中所述和定义的亚砜氧基团的4-(邻)-氟苯基-5-氟嘧啶-2-基胺衍生物，以及其制备方法，其用于治疗和/或预防疾病，特别是高增殖性疾病和/或病毒诱导的传染病和/或心血管疾病。本发明还涉及在制备所述一般式（I）化合物中有用的中间化合物。
• [EN] FLUORINATED BENZOFURANYL-PYRIMIDINE DERIVATIVES CONTAINING A SULFONE GROUP<br/>[FR] DÉRIVÉS DE BENZOFURANYLE-PYRIMIDINE FLUORÉS CONTENANT UN GROUPE SULFONE
  申请人：BAYER PHARMA AG

  公开号：WO2016059011A1

  公开（公告）日：2016-04-21

  The present invention relates to fluorinated benzofuranyl-pyrimidine derivatives containing a sulfone group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I). R2 represents the group (a).

  本发明涉及含有一种磺酮基团的氟苯并呋喃基嘧啶衍生物，其通式（I）如本说明所述和定义的，以及其制备方法，其用于治疗和/或预防疾病，特别是高增殖性疾病和/或病毒感染性疾病和/或心血管疾病。本发明还涉及在制备通式（I）所述化合物中有用的中间化合物。R2代表该基团（a）。
• [EN] FLUORINATED BENZOFURANYL-PYRIMIDINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP<br/>[FR] DÉRIVÉS DE BENZOFURANYLE-PYRIMIDINE FLUORÉS CONTENANT UN GROUPE SULFOXIMINE
  申请人：BAYER PHARMA AG

  公开号：WO2016059086A1

  公开（公告）日：2016-04-21

  The present invention relates to fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper- proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

  本发明涉及含有磺酰氧亚胺基团的氟代苯并呋喃基嘧啶衍生物，其一般式（I）如下所述，并定义了该衍生物，以及其制备方法，其用于治疗和/或预防疾病，特别是高增殖性疾病和/或病毒感染性疾病和/或心血管疾病。该发明还涉及用于制备上述一般式（I）化合物的中间体化合物。
• 4-ARYL-N-PHENYL-1,3,5-TRIAZIN-2-AMINES CONTAINING A SULFOXIMINE GROUP
  申请人：Lücking Ulrich

  公开号：US20140315906A1

  公开（公告）日：2014-10-23

  The present invention relates to 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (I) or (Ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I) or (Ia).

  本发明涉及一种含有磺酰亚胺基团的4-芳基-N-苯基-1,3,5-三嗪-2-胺的一般式(I)或(Ia)，以及其制备方法，其用于治疗和/或预防疾病，特别是高增殖性疾病和/或病毒引起的传染病和/或心血管疾病。本发明还涉及用于制备上述一般式(I)或(Ia)化合物的中间体化合物。