trans-1,4-Bis-(4-methoxycarbonylphenoxy)-2-butene | 660849-95-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trans-1,4-Bis-(4-methoxycarbonylphenoxy)-2-butene
• 英文别名: methyl 4-[(E)-4-(4-methoxycarbonylphenoxy)but-2-enoxy]benzoate
• CAS: 660849-95-6
• 化学式: C₂₀H₂₀O₆
• 分子量: 356.375
• InChiKey: RAUDWENAMRSIRH-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  trans-1,4-Bis-(4-methoxycarbonylphenoxy)-2-butene 在 sodium hydroxide 、 盐酸羟胺 作用下， 以 乙醇 、 水 为溶剂， 以40%的产率得到trans-1,4-Bis[4-(hydroxyaminocarbonyl)phenoxy]-2-butene
  参考文献：
  名称：

  Antiprotozoal activities of symmetrical bishydroxamic acids

  摘要：

  Symmetrical bishydroxamic acids along with their sodium salts containing an alkyl spacer between two aromatic rings were synthesized, and their antiparasitic activities were evaluated. Bishydroxamic acids were conveniently prepared from the alkylation of methyl 4-hydroxybenzoate with various dihalo-alkane, -alkene, and -ether followed by reaction with hydroxylamine. Surprisingly, the bishydroxamic acids and their sodium salts possess strong inhibitory activities against Plasmodium falciparum parasites with IC50 values in the range of 0.26-3.2 muM. Bishydroxamic acid 3 and its sodium salt 12 also inhibit the growth of Leishmania donovani, albeit at higher concentrations. The corresponding biscarboxylic acids and bismethyl esters are inactive. Presumably, the ability of bishydroxamic acids to complex with metallic iron in hemoglobin may be responsible for antimalarial activity of these compounds. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00522-4
• 作为产物：
  描述：

  反式-1,4-二氯-2-丁烯 、 对羟基苯甲酸甲酯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 以57%的产率得到trans-1,4-Bis-(4-methoxycarbonylphenoxy)-2-butene
  参考文献：
  名称：

  Zinc finger ejectors and methods of use thereof

  摘要：

  本发明揭示了从锌指肽中螯合或驱离Zn2+的技术，可用于治疗或控制病毒和疟疾等病。该发明包括在体内或体外将锌指肽与足够量的双羟肟酸或其盐接触。

  公开号：

  US20080039528A1

文献信息

• Antiprotozoal activities of symmetrical bishydroxamic acids
  作者：Duy H Hua、Masafumi Tamura、Masahiro Egi、Karl Werbovetz、Dawn Delfı́n、Manar Salem、Peter K Chiang

  DOI：10.1016/s0968-0896(03)00522-4

  日期：2003.10

  Symmetrical bishydroxamic acids along with their sodium salts containing an alkyl spacer between two aromatic rings were synthesized, and their antiparasitic activities were evaluated. Bishydroxamic acids were conveniently prepared from the alkylation of methyl 4-hydroxybenzoate with various dihalo-alkane, -alkene, and -ether followed by reaction with hydroxylamine. Surprisingly, the bishydroxamic acids and their sodium salts possess strong inhibitory activities against Plasmodium falciparum parasites with IC50 values in the range of 0.26-3.2 muM. Bishydroxamic acid 3 and its sodium salt 12 also inhibit the growth of Leishmania donovani, albeit at higher concentrations. The corresponding biscarboxylic acids and bismethyl esters are inactive. Presumably, the ability of bishydroxamic acids to complex with metallic iron in hemoglobin may be responsible for antimalarial activity of these compounds. (C) 2003 Elsevier Ltd. All rights reserved.
• Zinc finger ejectors and methods of use thereof
  申请人：Hua H. Duy

  公开号：US20080039528A1

  公开（公告）日：2008-02-14

  Techniques for the chelation or ejection of Zn2+ from zinc finger peptides are disclosed, which can be useful in the treatment or control of viruses and viral diseases and malaria. The invention comprises contacting a zinc finger peptide with an effective amount of a bishydroxamic acid or salt thereof, either in vivo or in vitro.

  本发明揭示了从锌指肽中螯合或驱离Zn2+的技术，可用于治疗或控制病毒和疟疾等病。该发明包括在体内或体外将锌指肽与足够量的双羟肟酸或其盐接触。