5-(3-甲酰基-4-羟基苯基)磺酰基-2-羟基苯甲醛 | 6954-29-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-(3-甲酰基-4-羟基苯基)磺酰基-2-羟基苯甲醛
• 英文名称: 5,5'-sulfonyl-bis-salicylaldehyde
• 英文别名: bissalicylaldehyde-5,5'-sulphone；5,5'-sulphonebissalicylaldehyde；NSC38049；6,6'-dihydroxy-3,3'-sulfonyl-di-benzaldehyde；6,6'-Dihydroxy-3,3'-sulfonyl-di-benzaldehyd；Bis-salicylaldehyd-5,5'-sulfon；3,3'-Sulfonylbis(6-hydroxybenzaldehyde)；5-(3-formyl-4-hydroxyphenyl)sulfonyl-2-hydroxybenzaldehyde
• CAS: 6954-29-6
• 化学式: C₁₄H₁₀O₆S
• 分子量: 306.296
• InChiKey: NRBDZRMCFXNSFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  ethyl 2-(triphenylphosphoranylidene)butanoate 、 5-(3-甲酰基-4-羟基苯基)磺酰基-2-羟基苯甲醛 以 二苯醚 为溶剂， 反应 4.0h， 以55%的产率得到3-ethyl-6-(3-ethyl-2-oxochromen-6-yl)sulfonylchromen-2-one
  参考文献：
  名称：

  Brahmbhatt, D. I.; Jayabalan, L.; Hirani, B. R., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998, vol. 37, # 7, p. 683 - 685

  摘要：

  DOI：
• 作为产物：
  描述：

  bis-(4-acetoxy-3-diacetoxymethyl-phenyl)-sulfone 在 硫酸 作用下， 生成 5-(3-甲酰基-4-羟基苯基)磺酰基-2-羟基苯甲醛
  参考文献：
  名称：

  Heat Stability Studies on Chelates from Schiff Bases of Salicylaldehyde Derivatives. II

  摘要：

  DOI：

  10.1021/ja01537a020

文献信息

• Synthesis and crystal structure of [2 + 2] calixsalens
  作者：Sankareswaran Srimurugan、Balasubramanian Viswanathan、Thirukallam Kanthadai Varadarajan、Babu Varghese

  DOI：10.1039/b604003a

  日期：——

  Efficient synthesis of chiral [2 + 2] macrocyclic tetraimines which display calixarene-like crystal structures has been described, with short reaction times under microwave irradiation.

  已描述了具有杯芳烃类晶体结构的手性[2+2]大环四亚胺的高效合成方法，该方法在微波辐射下反应时间短。
• Rawat, M. S. M.; Norula, J. L., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1987, vol. 26, # 1-12, p. 232 - 237
  作者：Rawat, M. S. M.、Norula, J. L.

  DOI：——

  日期：——
• Microwave assisted cyclocondensation of dialdehydes with chiral diamines forming calixsalen type macrocycles
  作者：Sankareswaran Srimurugan、Balasubramanian Viswanathan、Thirukkallam Kanthadai Varadarajan、Babu Varghese

  DOI：10.1016/j.tetlet.2005.03.089

  日期：2005.5

  Microwave irradiation of various dialdellydes and chiral diamines afforded chiral macrocyclic imines in moderate to good yields. Linked dialdehydes predominantly form [2+2] macrocycles whereas dialdehydes without linkers yield [3+3] macrocycles. This is the first report of template-free synthesis of calixsalen-type macrocycles formed in shorter reaction times under micro vave conditions. In all the reactions, the salts of chiral diamines were used in contrast to the free diamines normally employed. (c) 2005 Elsevier Ltd. All rights reserved.
• [EN] BISPHENOLS IN CANCER THERAPY<br/>[FR] BISPHÉNOLS UTILISÉS DANS LE TRAITEMENT DU CANCER
  申请人：UNIV MANITOBA

  公开号：WO2009072002A2

  公开（公告）日：2009-06-11

  The present invention generally relates to anticancer agents and methods of treating cancer. The anticancer agents described herein comprise a bisphenol core and generally act as topoisomerase II inhibitors, though their anticancer activity may be related to other mechanisms as well. The bisphenols discussed therein may also protect certain cells against detrimental effects of topoisomerase II poisons.