N,N'-bis-(4-hydroxybenzylidene)benzene-1,4-diamine | 112143-03-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N,N'-bis-(4-hydroxybenzylidene)benzene-1,4-diamine
• 英文别名: bis-(4-hydroxy-benzylidene)-p-phenylenediamine；Bis-(4-hydroxy-benzyliden)-p-phenylendiamin；4,4'-[1,4-phenylenebis(nitrilomethylidyne)]bis-phenol
• CAS: 112143-03-0
• 化学式: C₂₀H₁₆N₂O₂
• 分子量: 316.359
• InChiKey: MKWLHZZHWQHHGA-JFMUQQRKSA-N

物化性质

• 沸点：
  572.3±45.0 °C(Predicted)
• 密度：
  1.15±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  65.18
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  N,N'-bis-(4-hydroxybenzylidene)benzene-1,4-diamine 在 sodium tetrahydroborate 作用下， 以 乙二醇二甲醚 为溶剂， 反应 3.0h， 以71%的产率得到N,N'-bis-(4-hydroxybenzyl)benzene-1,4-diamine
  参考文献：
  名称：

  N,N‘-Bisbenzylidenebenzene-1,4-diamines and N,N‘-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors

  摘要：

  A series of N,N'-bisbenzylidenebenzene-1,4-diamine and N,N'-bisbenzylidenenaphthalene-1,4-diamine derivatives were synthesized as inhibitors for human sirtuin type 2 (SIRT2). The design of the new compounds was based on two earlier reported hits from molecular modeling and virtual screening. The most potent compound was N,N'-bis(2-hydroxybenzylidene)benzene-1,4-diamine, which was equipotent with the most potent hit compound and well-known SIRT2 inhibitor sirtinol.

  DOI：

  10.1021/jm060566j
• 作为产物：
  描述：

  对羟基苯甲醛 、 对苯二胺 在 tin(II) chloride dihdyrate 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以82.4%的产率得到N,N'-bis-(4-hydroxybenzylidene)benzene-1,4-diamine
  参考文献：
  名称：

  氯化亚锡催化羟基苯甲醛合成席夫碱及其ABTS和DPPH法测定其抗氧化活性

  摘要：

  摘要酚类化合物具有抗氧化活性，可以预防由自由基引起的有害疾病，因此在人类生活中起着非常重要的作用。在目前的工作中，我们使用氯化亚锡（\（\ hbox {SnCl} _ {2} {\ cdot} 2 \ hbox {H} _ {2}通过不同的羟基苯甲醛和伯芳族二胺的反应合成了一些席夫碱\ hbox {O} \））作为催化剂。通过FT-IR光谱，GCMS和NMR光谱对产物进行表征。此外，通过使用DPPH测定法和ABTS测定法测定席夫碱的抗氧化活性，并将结果与​​标准化合物，trolox以及母体醛进行比较。发现合成的化合物比其相应的母体醛具有更好的抗氧化活性。 图形摘要通过使用\（\ hbox {SnCl} _ {2} \ cdot 2 \ hbox {H} _ {2} \ hbox {O} \）作为催化剂，通过不同的羟基苯甲醛与伯芳族二胺的反应合成酚类席夫碱。以二氯甲烷为溶剂。通过DPPH测定

  DOI：

  10.1007/s12039-019-1645-2

文献信息

• α-AMINOPHOSPHONATES BEARING FREE HYDROXYL GROUPS IN THE AROMATIC RINGS. SYNTHESIS AND NMR CHARACTERIZATION
  作者：Salvatore Failla、Paolo Finocchiaro、Gerhard Hägele、Vitaly I. Kalchenko

  DOI：10.1080/10426509708031564

  日期：1997.9

  very good yields to mono- and bis-α-aminophosphonic acid dialkylesters containing the free phenolic hydroxyl group in a strategic position of the aromatic ring in order to enhance complexation with metal ions. This synthetic procedure is based on the addition of a solution of sodium dialkyl phosphite in phosphite to imine precursors. The addition reaction is highly stereospecific: only one diastereomer

  摘要 在本文中，我们描述了一种有用的合成方法，该方法可以产生非常好的单-和双-α-氨基膦酸二烷基酯，在芳环的战略位置含有游离酚羟基，以增强与金属离子的络合。该合成过程基于将亚磷酸二烷基酯钠溶液添加到亚胺前体中。加成反应是高度立体有择的：每个双-α-氨基膦酸二烷基酯仅形成一种非对映异构体。所有化合物均通过 NMR（1H 和 31P）和 FAB-MS 光谱表征。
• Gawinecki, Ryszard; Muzalewski, Feliks, Polish Journal of Chemistry, 1984, vol. 58, # 10-12, p. 1091 - 1098
  作者：Gawinecki, Ryszard、Muzalewski, Feliks

  DOI：——

  日期：——
• The War on Drugs and the War on Abortion: Some Initial Thoughts on the Connections, Intersections and Effects
  作者：Lynn M Paltrow

  DOI：10.1016/s0968-8080(02)00013-7

  日期：2002.1

  While many people view the war on abortion and the war on drugs on the part of state and federal governments in the USA as distinct, there are in fact many connections and a great deal of overlap between the two. Their histories, the strategies used to control and punish certain reproductive choices and those to control the use of certain drugs, the limitations that are placed on access to abortion and other reproductive health care and drug treatment, and the populations most harmed by those limitations are remarkably similar. These similarities are particularly apparent where the issues coalesce in the regulation and punishment of pregnant, drug-using women [1]. Efforts to control reproduction and drugs are rooted in forms of bigotry and prejudice that are essentially the same; African-American women are particularly harmed by them [2]. These efforts reflect a common political agenda and draw attention away from real underlying issues, including poverty, race discrimination and lack of a coherent national health care policy. Those who fight against each of them must recognize that they have a common cause and need a comprehensive strategy to address both as fundamental issues of social justice. (C) 2001 Southern University Law Review. Published by Elsevier Science on behalf of Reproductive Health Matters.
• Psyllid Attractants and Their Uses
  申请人：INSCENT, INC.

  公开号：US20130287727A1

  公开（公告）日：2013-10-31

  The present specification discloses psyllid attractants, compositions comprising such attractants, lures, traps and other devices using such attractants, methods and uses to attract, capture and/or kill psyllids using such attractants, compositions and/or lures, traps and/or other devices, and methods and uses for monitoring a psyllid population using such attractants, compositions and/or lures, traps and/or other devices.
• [EN] PSYLLID ATTRACTANTS AND THEIR USES<br/>[FR] ATTRACTEURS DE PSYLLES ET LEURS UTILISATIONS
  申请人：INSCENT INC

  公开号：WO2013163454A2

  公开（公告）日：2013-10-31

  The present specification discloses psyllid attractants, compositions comprising such attractants, lures, traps and other devices using such attractants, methods and uses to attract, capture and/or kill psyllids using such attractants, compositions and/or lures, traps and/or other devices, and methods and uses for monitoring a psyllid population using such attractants, compositions and/or lures, traps and/or other devices.