2-(2-(2-ethoxyethoxy)ethyl)isoindoline-1,3-dione | 23702-87-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(2-(2-ethoxyethoxy)ethyl)isoindoline-1,3-dione
• 英文别名: 1-phthalimido-3,6-dioxaoctane；N-(3,6-dioxaoctyl)phthalimide；N-[2-(2-ethoxy-ethoxy)-ethyl]-phthalimide；N-<2-(2-Ethoxyethoxy)-ethyl>-phthalimid；2-[2-(2-Ethoxyethoxy)ethyl]isoindole-1,3-dione
• CAS: 23702-87-6
• 化学式: C₁₄H₁₇NO₄
• 分子量: 263.293
• InChiKey: OTJIHJQDHOGELS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2-(2-ethoxyethoxy)ethyl)isoindoline-1,3-dione 在 一水合肼 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以64%的产率得到2-(2-乙氧基乙氧基)-乙胺
  参考文献：
  名称：

  Perhydrotriquinacenic hosts. 1. Synthesis, complexation and transport properties of tripodands of C3 symmetry.

  摘要：

  A general strategy for the synthesis of tripodands of C3 symmetry, which involves the reductive amination of tricyclo[5.2.1.0(4),10]decane-2,5,8-trione 1, is described. Preliminary studies show that these tripodands exhibit complexation and transport properties similar to those of previously described podands.

  DOI：

  10.1016/s0040-4020(01)86537-6
• 作为产物：
  描述：

  二乙二醇乙醚 在 吡啶 作用下， 以 邻二甲苯 为溶剂， 反应 18.0h， 生成 2-(2-(2-ethoxyethoxy)ethyl)isoindoline-1,3-dione
  参考文献：
  名称：

  Perhydrotriquinacenic hosts. 1. Synthesis, complexation and transport properties of tripodands of C3 symmetry.

  摘要：

  A general strategy for the synthesis of tripodands of C3 symmetry, which involves the reductive amination of tricyclo[5.2.1.0(4),10]decane-2,5,8-trione 1, is described. Preliminary studies show that these tripodands exhibit complexation and transport properties similar to those of previously described podands.

  DOI：

  10.1016/s0040-4020(01)86537-6

文献信息

• HYBRID BLOCK COPOLYMER MICELLES WITH MIXED STEREOCHEMISTRY FOR ENCAPSULATION OF HYDROPHOBIC AGENTS
  申请人：SILL Kevin N.

  公开号：US20080274173A1

  公开（公告）日：2008-11-06

  The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.

  本发明涉及聚合物化学领域，更具体地说是涉及多嵌段共聚物以及包含该共聚物的胶束。
• Luk'yanenko, N. G.; Bogat-skii, A. V.; Shapkin, V. A., Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, p. 944 - 950
  作者：Luk'yanenko, N. G.、Bogat-skii, A. V.、Shapkin, V. A.、Popkov, Yu. A.

  DOI：——

  日期：——
• Immunosuppressive but Non-LasR-Inducing Analogues of the <i>Pseudomonas aeruginosa</i> Quorum-Sensing Molecule <i>N</i>-(3-Oxododecanoyl)-<scp>l</scp>-homoserine Lactone
  作者：Gopal P. Jadhav、Siri Ram Chhabra、Gary Telford、Doreen S. W. Hooi、Karima Righetti、Paul Williams、Barrie Kellam、David I. Pritchard、Peter M. Fischer

  DOI：10.1021/jm2001019

  日期：2011.5.12

  The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone (1) is involved not only in bacterial activation but also in subversion of the host immune system, and this compound might thus be used as a template to design immunosuppressive agents, provided derivatives devoid of quorum-sensing activity could be discovered. By use of a leukocyte proliferation assay and a newly developed bioluminescent P. aeruginosa reporter assay, systematic modification of 1 allowed us to delineate the bacterial LasR-induction and host immunosuppressive activities. The main determinant is replacement of the methylene group proximal to the beta-ketoamide in the acyl chain of 1 with functions containing heteroatoms, especially an NH group. This modification can be combined with replacement of the homoserine lactone system in 1 with stable cyclic groups. For example, we found the simple compound N(1)-(5-chloro-2-hydroxyphenyl)-N(3)-octylmalonamide (25d) to be over twice as potent as 1 as an immune suppressor while displaying LasR-induction antagonist activity.
• ENCAPSULATED CONTRAST AGENTS
  申请人：Skaff Habib

  公开号：US20090092554A1

  公开（公告）日：2009-04-09

  The present invention relates to the field of polymer chemistry and more particularly to encapsulated contrast agents and methods for using the same.
• Immunotherapy for Treatment of Amyloid-Related Disorders Using Encapsulated Beta-Amyloid Peptides
  申请人：CAO CHUANHAI

  公开号：US20100136063A1

  公开（公告）日：2010-06-03

  The present invention relates to the field of polymer chemistry and more particularly to encapsulated peptides and uses thereof.