N,N'-dimethyldecane-1,10-diamine | 88682-11-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-dimethyldecane-1,10-diamine
• 英文别名: 1,10-N,N'-dimethyldecanediamine；N,N'-dimethyl-decanediyldiamine；N,N'-Dimethyl-decandiyldiamin；N,N'-Dimethyl-dekamethylen-diamin；1,10-Bis-methylamino-decan；1,10-Decanediamine, N,N'-dimethyl-
• CAS: 88682-11-5
• 化学式: C₁₂H₂₈N₂
• 分子量: 200.368
• InChiKey: CUPURULQCIFHFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-dimethyldecane-1,10-diamine 在 lithium aluminium tetrahydride 、 氯甲酸乙酯 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 12.5h， 生成
  参考文献：
  名称：

  Piergentili; Quaglia; Tayebati, Il Farmaco, 1994, vol. 49, # 2, p. 83 - 87

  摘要：

  DOI：
• 作为产物：
  描述：

  1,10-二溴癸烷 在 palladium on activated charcoal 、 乙醇 作用下， 生成 N,N'-dimethyldecane-1,10-diamine
  参考文献：
  名称：

  188.合成的长链脂族化合物。第九部分 一些抗结核的长链胺

  摘要：

  DOI：

  10.1039/jr9520001057

文献信息

• Local anesthetic compounds and uses
  申请人：Advanced Medicine, Inc.

  公开号：US06337423B1

  公开（公告）日：2002-01-08

  Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.

  本发明揭示了用于产生长时期局部麻醉的新化合物、药物组合物和方法。本发明的化合物是多结合化合物，包括从2到10个配体共价连接到一个或多个连接物的结构，每个配体能够结合到电压门控Na+通道中的一个配体结合位点，以调节其生物过程/功能。
• Nickel-catalyzed hydrogenative coupling of nitriles and amines for general amine synthesis
  作者：Vishwas G. Chandrashekhar、Wolfgang Baumann、Matthias Beller、Rajenahally V. Jagadeesh

  DOI：10.1126/science.abn7565

  日期：2022.6.24

  Efficient and general methods for the synthesis of amines remain in high demand in the chemical industry. Among the many known processes, catalytic hydrogenation is a cost-effective and industrially proven reaction and currently used to produce a wide array of such compounds. We report a homogeneous nickel catalyst for hydrogenative cross coupling of a range of aromatic, heteroaromatic, and aliphatic

  合成胺的有效和通用方法在化学工业中仍然有很高的需求。在许多已知的方法中，催化加氢是一种经济有效且经工业验证的反应，目前用于生产多种此类化合物。我们报告了一种均相镍催化剂，用于将一系列芳族、杂芳族和脂肪族腈与伯胺和仲胺或氨进行氢化交叉偶联。该通用氢化方案通过直接和高选择性合成 > 230 种功能化和结构多样的胺（包括药学相关和手性产物）以及15N-同位素标记应用。
• Manganese‐Catalyzed Mono‐<i>N</i>‐Methylation of Aliphatic Primary Amines without the Requirement of External High‐Hydrogen Pressure
  作者：Jiale Ji、Yinghao Huo、Zhaowen Dai、Zhening Chen、Tao Tu

  DOI：10.1002/anie.202318763

  日期：2024.3.22

  A synergistic strategy enables the selective synthesis of mono-N-methylated aliphatic primary amines, including deuterium-labelled drugs. This innovative approach combines an earth-abundant manganese catalyst with a weak base, resulting in a practical and sustainable protocol for mono-N-methylation. By effectively inhibiting the formation of formamide byproducts, it eliminates the need for external

  协同策略能够选择性合成单N-甲基化脂肪族伯胺，包括氘标记的药物。这种创新方法将地球上丰富的锰催化剂与弱碱相结合，形成了实用且可持续的单N-甲基化方案。通过有效抑制甲酰胺副产物的形成，无需外部高压氢气。
• COMPOSITION CONTAINING COMPOUND HAVING DITHIOCARBONATE GROUP
  申请人：Kyowa Yuka Co., Ltd.

  公开号：EP1167458A1

  公开（公告）日：2002-01-02

  A composition comprising a compound having at least one 5-membered-ring dithiocarbonate group represented by general formula (I): (in the formula, R1, R2, and R3 are identical or different, and represent a hydrogen atom or lower alkyl), and a secondary diamine represented by general formula (II): (in the formula, X represents alkylene having 4 to 20 carbon atoms) or an enamine derivative thereof is useful for use in coating materials, adhesives, inks, sealants, sealing agents, or the like.

  一种组合物，包括至少有一个 5 元环二硫代碳酸酯基团的化合物，由通式(I)代表： (式中，R1、R2和R3相同或不同，并代表氢原子或低级烷基)，以及由通式(II)代表的仲二胺： (式中，X 代表具有 4 至 20 个碳原子的亚烷基）的仲二胺或其烯胺衍生物可用于涂层材料、粘合剂、油墨、密封剂、密封剂等。
• ANTISTATIC AGENT, ANTISTATIC AGENT COMPOSITION, ANTISTATIC RESIN COMPOSITION, AND MOLDED BODY
  申请人：Adeka Corporation

  公开号：EP2949721A1

  公开（公告）日：2015-12-02

  Provided are: an antistatic agent which is capable of imparting excellent antistatic effect in a small amount and has sufficient persistence and wiping resistance; an antistatic agent composition; an antistatic resin composition; and a molded article. The antistatic agent comprises a polymer compound (E) having a structure in which a block polymer (C) and an epoxy compound (D) are bound via an ester bond formed by a carboxyl group of the block polymer (C) and an epoxy group of the epoxy compound (D), the block polymer (C) having a structure comprising carboxyl groups at both ends, in which structure a block constituted by a polyester (A) having carboxyl groups at both ends and a block constituted by a compound (B) having hydroxyl groups at both ends are repeatedly and alternately bound via ester bonds formed by the carboxyl groups and the hydroxyl groups, and the epoxy compound (D) comprising two or more epoxy groups.

  本发明提供了：一种抗静电剂，该抗静电剂能够以少量提供优异的抗静电效果，并具有足够的持久性和耐擦拭性；一种抗静电剂组合物；一种抗静电树脂组合物；以及一种成型制品。抗静电剂包括聚合物化合物（E），其结构是嵌段聚合物（C）和环氧化合物（D）通过由嵌段聚合物（C）的羧基和环氧化合物（D）的环氧基形成的酯键结合在一起，嵌段聚合物（C）具有两端包含羧基的结构、在该结构中，由两端具有羧基的聚酯（A）构成的嵌段和由两端具有羟基的化合物（B）构成的嵌段通过由羧基和羟基形成的酯键反复交替结合，环氧化合物（D）包括两个或多个环氧基团。