1,13-bis(bis(3,5-dimethylphenyl)phosphino)-7,8-dihydro-6H-dibenzo[f,h][1,5]dioxonine | 337359-59-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,13-bis(bis(3,5-dimethylphenyl)phosphino)-7,8-dihydro-6H-dibenzo[f,h][1,5]dioxonine
• 英文别名: 1,13-bis(bis(3,5-dimethylphenyl)phosphino)-7,8-dihydro-6H-dibenzo[f,h][1,5]dioxonin；(+)-xylyl-C3-TUNEPHOS；[17-Bis(3,5-dimethylphenyl)phosphanyl-8,12-dioxatricyclo[11.4.0.02,7]heptadeca-1(13),2(7),3,5,14,16-hexaen-3-yl]-bis(3,5-dimethylphenyl)phosphane；[17-bis(3,5-dimethylphenyl)phosphanyl-8,12-dioxatricyclo[11.4.0.02,7]heptadeca-1(13),2(7),3,5,14,16-hexaen-3-yl]-bis(3,5-dimethylphenyl)phosphane
• CAS: 337359-59-8
• 化学式: C₄₇H₄₈O₂P₂
• 分子量: 706.844
• InChiKey: CJVIXZONXCRJSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.9
• 重原子数：
  51
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 1,13-bis(bis(3,5-dimethylphenyl)phosphino)-7,8-dihydro-6H-dibenzo[f,h][1,5]dioxonine 以 甲醇 为溶剂， 反应 2.0h， 生成 [RuCl(p-cymene)((+)-xylyl-c3-tunephos)]Cl
  参考文献：
  名称：

  [EN] RUTHENIUM COMPLEX AND METHOD FOR PREPARING OPTICALLY ACTIVE ALCOHOL COMPOUND
  [FR] COMPLEXE DE RUTHÉNIUM ET PROCÉDÉ POUR PRÉPARER UN COMPOSÉ ALCOOLIQUE OPTIQUEMENT ACTIF

  摘要：

  本发明提供了一种新型钌配合物，其在对羰基化合物的不对称还原反应活性和对映选择性方面具有优异的催化活性，以及使用该钌配合物的催化剂和制备光学活性醇化合物的方法。本发明涉及具有钌环结构的钌配合物，由该钌配合物组成的不对称还原催化剂，以及使用该钌配合物制备光学活性醇的方法。

  公开号：

  WO2011135753A1

文献信息

• PROCESS FOR PRODUCING OPTICALLY ACTIVE AMINE
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20150210657A1

  公开（公告）日：2015-07-30

  A process for producing an optically active amine compound, characterized by asymmetrically hydrogenating a prochiral carbon-nitrogen double bond in the presence of a ruthenium complex represented by general formula (1) or (2) (wherein P represents an optically active diphosphine, X represents an anionic group, and Ar represents an optionally substituted arylene group).

  一种制备光学活性胺化合物的方法，其特征在于在存在由通用式（1）或（2）表示的钌配合物的情况下，对一个丙半胱氨基双键进行不对称氢化（其中P代表光学活性二膦，X代表阴离子基团，Ar代表可选择取代的芳基基团）。
• RUTHENIUM COMPLEX AND METHOD FOR PREPARING OPTICALLY ACTIVE ALCOHOL COMPOUND
  申请人：Nara Hideki

  公开号：US20130041151A1

  公开（公告）日：2013-02-14

  The present invention provides a novel ruthenium complex which has an excellent catalytic activity in terms of reactivity for asymmetric reduction of a carbonyl compound and enantioselectivity, a catalyst using the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex. The present invention relates to a ruthenium complex having ruthenacycle structure, a catalyst for asymmetric reduction consisting of the ruthenium complex, and a method for preparing optically active alcohol using the ruthenium complex.

  本发明提供了一种新型的钌配合物，该配合物在对羰基化合物的不对称还原反应中具有优异的催化活性和对映选择性，以及使用该钌配合物的催化剂和制备光学活性醇化合物的方法。本发明涉及一种具有钌环结构的钌配合物，一种由该钌配合物组成的不对称还原催化剂，以及使用该钌配合物制备光学活性醇的方法。
• NOVEL RUTHENIUM COMPLEX AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND USING SAME AS CATALYST
  申请人：Hori Kiyoto

  公开号：US20140187809A1

  公开（公告）日：2014-07-03

  The present invention provides a novel ruthenium complex which has an excellent catalytic activity in terms of reactivity for an asymmetric reduction of a carbonyl compound and enantioselectivity, a catalyst using the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex. The present invention relates to a ruthenium complex having a ruthenacycle structure, a catalyst for an asymmetric reduction consisting of the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex.

  本发明提供了一种新型的钌配合物，其在对羰基化合物的不对称还原反应中具有优异的催化活性和对映选择性，还提供了使用该钌配合物制备光学活性醇化合物的催化剂和方法。本发明涉及一种具有钌环结构的钌配合物、用于不对称还原反应的催化剂，以及使用该钌配合物制备光学活性醇化合物的方法。
• METHOD FOR PRODUCING PKROSTAGLANDIN
  申请人：KYOWA PHARMA CHEMICAL CO., LTD.

  公开号：US20220169600A1

  公开（公告）日：2022-06-02

  The present invention provides a method for producing a compound represented by Formula (1a), (1b), or (1c), comprising a step of reducing a compound represented by Formula (3) in the presence of a metal complex represented by Formula (5), an inorganic base, and a solvent under a hydrogen atmosphere to obtain a compound represented by Formula (4). In the formula, Ar 1 is an aryl group, each Are is independently a phenyl group or the like, W is a biphenyl group or the like, Z is an ethylene group that is substituted with a phenyl group or the like, and L is a chlorine atom or if Z has a phenyl group or a C 1-3 alkoxyphenyl group, L is one of carbon atoms constituting the phenyl group or the C 1-3 alkoxyphenyl group.

  本发明提供了一种制备由公式（1a），（1b）或（1c）表示的化合物的方法，包括在氢气气氛下，在公式（5）表示的金属配合物，无机碱和溶剂的存在下，还原由公式（3）表示的化合物以获得由公式（4）表示的化合物。在该式中，Ar1是芳基基团，每个Are独立地是苯基或类似的基团，W是联苯基团或类似的基团，Z是被苯基或类似基团取代的乙烯基团，如果Z具有苯基或C1-3烷氧基苯基基团，则L是构成苯基或C1-3烷氧基苯基基团的碳原子之一。
• Optically active diphosphine compound, production intermediates therefor, transition metal complex containing the compound as ligand and asymmetric hydrogenation catalyst containing the complex
  申请人：Takasago International Corporation

  公开号：EP1095946A1

  公开（公告）日：2001-05-02

  This invention provides a novel diphosphine compound which is useful as a ligand of catalysts for asymmetric synthesis reactions, particularly asymmetric hydrogenation reaction. Particularly, it provides a diphosphine compound represented by a general formula (1) : wherein R1 and R2 each independently represents a cycloalkyl group, an unsubstituted or substituted phenyl group or a five-membered aromatic heterocycle residue.

  本发明提供了一种新型二膦化合物，可用作不对称合成反应，特别是不对称氢化反应催化剂的配体。特别是，本发明提供了一种由通式（1）表示的二膦化合物： 其中 R1 和 R2 各自独立地代表环烷基、未取代或取代的苯基或五元芳香杂环残基。