N-(2-(pyridin-2-yldisulfanyl)ethyl)acrylamide | 910621-98-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(2-(pyridin-2-yldisulfanyl)ethyl)acrylamide
• 英文别名: 2-(pyridin-2-yldisulfaneyl)ethyl-acrylamide；n-[2-(2-pyridyldithio)ethyl]-2-propenamide；N-[2-(2-Pyridinyldithio)ethyl]-2-propenamide；N-[2-(pyridin-2-yldisulfanyl)ethyl]prop-2-enamide
• CAS: 910621-98-6
• 化学式: C₁₀H₁₂N₂OS₂
• 分子量: 240.35
• InChiKey: BWTGZRAIFPNYIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  92.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丙烯酰氯 、 2-(2-pyridinyldisulfanyl)ethanamine hydrochloride 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 21.19h， 生成 N-(2-(pyridin-2-yldisulfanyl)ethyl)acrylamide
  参考文献：
  名称：

  Control of the poly(N-isopropylacrylamide) phase transition via a single strand–double strand transformation of conjugated DNA

  摘要：

  我们已经证明，通过改变 DNA 的电荷数量和亲水状态，从单链 DNA (ssDNA) 形成双链 DNA (dsDNA)，从而抑制 DNA 共轭热敏聚合物的聚集。该聚合物是通过将短 ssDNA 与聚（N-异丙基丙烯酰胺）（PNIPAM）缀合，然后将缀合的 DNA 与互补 DNA 杂交形成 dsDNA 来制备的。 ssDNA缀合的PNIPAM随着温度的升高而高度聚集，而dsDNA缀合的PNIPAM通过与完全匹配的互补DNA杂交而被抑制聚集，并通过与具有突出序列的较长互补DNA杂交而进一步防止聚集。进一步的表征表明，ssDNA 和 dsDNA 缀合的 PNIPAM 之间聚集程度的差异主要是由与缀合 DNA 相关的电荷数量的变化驱动的。

  DOI：

  10.1039/c3sm27230c

文献信息

• Polymer/copper combination for targeted cancer therapy
  申请人：University of South Carolina

  公开号：US10221271B2

  公开（公告）日：2019-03-05

  Polymer/copper combinations that can selectively target and kill cancer cells are described. Materials can include the reaction product of a biocompatible hydrophilic polymer and pyridine-2-thiol containing monomer. The copolymer reaction product can include pyridine-2-thiol side groups pendant to the backbone via a disulfide linkage. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.

  本文介绍了可选择性靶向和杀死癌细胞的聚合物/铜组合物。材料可包括生物相容性亲水性聚合物和含吡啶-2-硫醇单体的反应产物。共聚物反应产物可包括通过二硫连接悬挂在主链上的吡啶-2-硫醇侧基。亲水组分可形成聚合物骨架和/或在骨架上形成亲水悬垂基团。铜离子可与共聚物结合。
• Fabrication and application of a hetero-targeted nano-cocktail with traceless linkers
  申请人：UNIVERSITY OF SOUTH CAROLINA

  公开号：US11478493B2

  公开（公告）日：2022-10-25

  A hetero-targeted, dual-responsive nanogel to deliver chemotherapeutic agents to a metastatic cancer is provided. The nanogel includes a first chemotherapeutic agent, a second chemotherapeutic agent, a first targeting ligand, and a second targeting ligand. A method of treating cancer in a mammal with the nanogel are also provided.

  本发明提供了一种异种靶向、双响应纳米凝胶，用于向转移性癌症递送化疗药物。纳米凝胶包括第一种化疗药物、第二种化疗药物、第一种靶向配体和第二种靶向配体。还提供了一种用纳米凝胶治疗哺乳动物癌症的方法。
• AN ANTIMICROBIAL AGENT COMPRISING A CYSTEINE COMPOUND COVALENTLY BOUND TO A SUBSTRATE, IN PARTICULAR BY BINDING THROUGH AN S-S BRIDGE VIA A SPACER MOLECULE
  申请人：Cytacoat AB

  公开号：EP1860937B1

  公开（公告）日：2016-05-25
• Antimicrobial Agent Comprising a Cysteine Compound Covalently Bound to a Substrate In Particular by Binding Through an S-S Bridge Via a Spacer Molecule
  申请人：Wirsen Anders

  公开号：US20080153911A1

  公开（公告）日：2008-06-26

  The invention relates to an antimicrobial agent where a cysteine compound is covalently bound to a substrate, in particular by binding through an S—S bridge via a spacer molecule to the substrate. The spacer comprises a carbon chain, optionally interrupted by one or more heteroatoms, e.g. O, S, N, P and Si; the chain is optionally substituted with one or more alkyl groups, preferably lower alkyl groups with 1-5 carbon atoms, hydroxyl groups or alkoxy groups. Also, the invention refers to a substrate that is coated with the antimicrobial agent of the invention. The agent has excellent antimicrobial properties and can be used to coat surfaces and substrates of various devices, such as medical devices or devices used in food handling, in order to prevent or inhibit accumulation and/or growth and/or proliferation and/or the viability of microorganisms and/or formation of biofilm.
• ANTIMICROBIAL AGENT COMPRISING A CYSTEINE COMPONENT COVALENTLY BOUND TO A SUBSTRATE IN PARTICULAR BY BINDING THROUGH AN S-S BRIDGE VIA A SPACER MOLECULE
  申请人：CYTACOAT AB

  公开号：US20140018423A1

  公开（公告）日：2014-01-16

  The invention relates to an antimicrobial agent where a cysteine compound is covalently bound to a substrate, in particular by binding through an S—S bridge via a spacer molecule to the substrate. The spacer comprises a carbon chain, optionally interrupted by one or more heteroatoms, e.g. O, S, N, P and Si; the chain is optionally substituted with one or more alkyl groups, preferably lower alkyl groups with 1-5 carbon atoms, hydroxyl groups or alkoxy groups. Also, the invention refers to a substrate that is coated with the antimicrobial agent of the invention. The agent has excellent antimicrobial properties and can be used to coat surfaces and substrates of various devices, such as medical devices or devices used in food handling, in order to prevent or inhibit accumulation and/or growth and/or proliferation and/or the viability of microorganisms and/or formation of biofilm.