thiamin triphosphate | 50851-39-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: thiamin triphosphate
• 英文别名: Thiamine triphosphate；ThTP；3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-4-methyl-5-[2-(tetrahydroxy-[1]triphosphoryloxy)-ethyl]-thiazolium；O-Tetrahydroxytriphosphoryl-thiamin；Thiamin-tripyrophosphat；O-(tetrahydroxy-[1]triphosphoryl)-thiamin；[2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• CAS: 50851-39-3
• 化学式: C₁₂H₂₀N₄O₁₀P₃S
• 分子量: 505.299
• InChiKey: IWLROWZYZPNOFC-UHFFFAOYSA-O

物化性质

• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  244
• 氢给体数：
  5
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  盐酸硫胺 、 thiamin triphosphate 在 偏磷酸 作用下， 生成 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-4-methyl-5-(2-trihydroxydiphosphoryloxy-ethyl)-thiazolium; salt of/the/ L--aspartic acid 、 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl dihydrogen phosphate
  参考文献：
  名称：

  用于生产共羧化酶和神经磷酸三磷酸酯

  摘要：

  再次检查了由正磷酸通过加热制备的间磷酸溶液对动脉瘤的磷酸化作用。确定了可以得到更精确的条件，在该条件下可以得到三磷酸神经磷酸酯和二磷酸神经磷酸酯（共羧化酶）。

  DOI：

  10.1002/hlca.19490320515

文献信息

• ANTI-AGING AGENT CONTAINING ARCTIGENIN DERIVATIVE
  申请人：ROHTO Pharmaceutical Co., Ltd.

  公开号：US20150093345A1

  公开（公告）日：2015-04-02

  An arctigenin derivative used for anti-aging treatment, including protection of the skin from the sun and recovery of skin elasticity. A variety of fatty acid ester derivatives, alcohol ether derivatives and alkylated derivatives are used as the arctigenin derivatives. Agents for controlling ET-1 production, elastase inhibitors, and anti-inflammatory agents are prepared. Such arctigenin derivatives are particularly useful as an external agent for the skin, such as an anti-inflammatory external agent, a sunscreen external agent, or an external agent for recovering elasticity.

  一种用于抗衰老治疗的牛蒡素衍生物，包括保护皮肤免受阳光伤害和恢复皮肤弹性。使用各种脂肪酸酯衍生物、醇醚衍生物和烷基衍生物作为牛蒡素衍生物。制备用于控制ET-1产生的药剂、弹性蛋白酶抑制剂和抗炎药剂。这种牛蒡素衍生物特别适用于皮肤外用剂，如抗炎外用剂、防晒外用剂或恢复弹性的外用剂。
• [EN] A PROCESS FOR THE PREPARATION OF A THIAMINE DERIVATIVE AND SALT THEREOF<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION D'UN DÉRIVÉ DE THIAMINE ET D'UN SEL DE CELUI-CI
  申请人：ASHMI LIFE SCIENCES PRIVATE LTD

  公开号：WO2016079576A1

  公开（公告）日：2016-05-26

  A process for the preparation of a thiamine derivative and salt thereof, the process comprising the steps of: reacting thiamine chloride hydrochloride with phosphoric acid in the presence of a catalyst to produce a reaction mass of thiamine polyphosphates; isolating said thiamine derivative from said reaction mass of thiamine polyphosphates; and preparing salt of said thiamine derivative.

  一种制备硫胺素衍生物及其盐的方法，包括以下步骤：在催化剂的存在下，将硫胺素氯化氢与磷酸反应，产生硫胺素多磷酸反应物；从硫胺素多磷酸反应物中分离出该硫胺素衍生物；制备该硫胺素衍生物的盐。
• Nanoparticles comprising half esters of poly (methyl vinyl ether-co-maleic anhydride) and uses thereof
  申请人：Bionanoplus, S.L.

  公开号：EP2510930A1

  公开（公告）日：2012-10-17

  The present invention relates to nanoparticles for encapsulating compounds, the preparation and uses thereof, said nanoparticles being based on half (C1-C4) alkyl esters of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) copolymers. Said nanoparticles can encapsulate or incorporate a product of interest. For use in the agricultural, cosmetic, food or pharmaceutical fields.

  本发明涉及一种基于半(C1-C4)烷基酯的聚(甲基乙烯醚-co-马来酸酐) (PVM/MA) 共聚物的纳米颗粒，其制备和用途，该纳米颗粒可以封装或包含所需的产品。适用于农业、化妆品、食品或制药领域。
• Methods for indentifying compounds that modulate an enzyme in the coenzyme a biosynthetic pathway in a pathogenic microoganism
  申请人：Schechter M. Alan

  公开号：US20060094075A1

  公开（公告）日：2006-05-04

  A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and compounds and pharmaceutical compositions for inhibiting infections of pathogenic microorganisms by inhibiting such enzymes.

  一种通过抑制代谢途径中一个或多个酶的活性，抑制底物转化为产生次终产物或终产物的过程，特别是通过抑制途径中一个或多个酶的活性，来识别和治疗病原微生物感染的方法，以及用于抑制这些酶而抑制病原微生物感染的化合物和药物组合物。
• Method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in an essential metabolic pathway
  申请人：Pyro Pharmaceuticals, Inc.

  公开号：US20030180830A1

  公开（公告）日：2003-09-25

  A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway

  一种通过抑制代谢途径中一个或多个酶的活性，从而抑制底物转化产生次终产物或最终产物，特别是通过抑制代谢途径中一个或多个酶的活性来识别和治疗病原微生物感染的方法。

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