5-(4-丁氧基苯基)-5-甲基咪唑烷-2,4-二酮 | 68524-18-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: 5-(4-丁氧基苯基)-5-甲基咪唑烷-2,4-二酮
• 英文名称: 5-<4-Butoxy-phenyl>-5-methyl-hydantoin
• 英文别名: 5-(4-butoxy-phenyl)-5-methyl-imidazolidine-2,4-dione；HYDANTOIN, 5-(p-BUTOXYPHENYL)-5-METHYL-；5-(4-butoxyphenyl)-5-methylimidazolidine-2,4-dione
• CAS: 68524-18-5
• 化学式: C₁₄H₁₈N₂O₃
• 分子量: 262.309
• InChiKey: QVVCPCUAQMNMNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(4-丁氧基苯基)-5-甲基咪唑烷-2,4-二酮 、 碘甲烷 在 sodium carbonate 作用下， 反应 6.0h， 以92%的产率得到5-(4-Butoxyphenyl)-3,5-dimethyl-2,4-imidazolidinedione
  参考文献：
  名称：

  3,5-Dimethyl-5-p-alkoxyphenylhydantoins and their neurotropic properties

  摘要：

  DOI：

  10.1007/bf00772018

文献信息

• CARBINOL DERIVATIVES HAVING CYCLIC LINKER
  申请人：Yamaguchi Yuki

  公开号：US20100048610A1

  公开（公告）日：2010-02-25

  [Object] To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate.

  提供一种新型的LXRβ激动剂，可用作预防和/或治疗动脉粥样硬化；动脉硬化，如糖尿病引起的动脉硬化；血脂异常；高胆固醇血症；与脂质相关的疾病；由炎性细胞因子引起的炎症性疾病；过敏性皮肤病；糖尿病；或阿尔茨海默病的治疗剂。【解决手段】以下一般式（I）所表示的羟甲基化合物或其盐，或其溶剂化合物。
• SUBSTITUTED CARBINOL COMPOUND HAVING CYCLIC LINKER
  申请人：Kowa Company, Ltd.

  公开号：EP2281817A1

  公开（公告）日：2011-02-09

  It is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. It is a carbinol compound represented by the following general formula (I) or salt thereof, or their solvate.

  本发明旨在提供一种新型 LXRβ 激动剂，可作为动脉粥样硬化、动脉硬化（如糖尿病引起的动脉硬化）、血脂异常、高胆固醇血症、血脂相关疾病、由炎性细胞因子引起的炎症性疾病、皮肤病（如过敏性皮肤病）、糖尿病或阿尔茨海默病的预防和/或治疗药物。 它是由以下通式(I)或其盐或它们的溶解物所代表的醇化合物。
• SUBSTITUTED CARBINOL COMPOUND
  申请人：Kowa Company, Ltd.

  公开号：EP2098515B1

  公开（公告）日：2012-02-08
• Synthesis and anticonvulsant activity of aminoalkyl derivatives of 5-(p-alkoxyphenyl)-5-methylhydantoins
  作者：L. V. Azaryan、S. A. Avetisyan、O. L. Mndzhoyan、I. A. Dzhagatspanyan、N. E. Akopyan

  DOI：10.1007/bf00766664

  日期：1984.5
• AZARYAN, L. V.;AVETISYAN, S. A.;MNDZHOYAN, O. L.;DZHAGATSPANYAN, I. A.;AK+, XIM.-FARMATS. ZH., 1984, 18, N 5, 568-572
  作者：AZARYAN, L. V.、AVETISYAN, S. A.、MNDZHOYAN, O. L.、DZHAGATSPANYAN, I. A.、AK+

  DOI：——

  日期：——