4-(N,N-diallylamino)phenol | 705239-83-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(N,N-diallylamino)phenol
• 英文别名: p-(diallylamino)phenol；4-diallylamino-phenol；4-[Bis(prop-2-enyl)amino]phenol
• CAS: 705239-83-4
• 化学式: C₁₂H₁₅NO
• 分子量: 189.257
• InChiKey: RTXKWXHAZJKJMV-UHFFFAOYSA-N

物化性质

• 沸点：
  125-137 °C(Press: 3 Torr)
• 密度：
  1.039±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(N,N-diallylamino)phenol 在 双氧水 、 potassium hydrogencarbonate 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 水 、 乙腈 为溶剂， 反应 15.0h， 生成 N,N-bis(oxiran-2-ylmethyl)-4-prop-2-enoxyaniline
  参考文献：
  名称：

  EPOXY COMPOUND HAVING ALKOXY SILYL GROUP, COMPOSITION COMPRISING SAME, CURED PRODUCT, USE THEREOF AND METHOD FOR PREPARING EPOXY COMPOUND HAVING ALKOXY SILYL GROUP

  摘要：

  公开号：

  EP2826777B1
• 作为产物：
  描述：

  allyl p-(diallylamino)phenyl ether 在 碘 作用下， 以 二甲基亚砜 为溶剂， 反应 0.5h， 以76%的产率得到4-(N,N-diallylamino)phenol
  参考文献：
  名称：

  烯丙基保护法轻松合成羟化黄酮的新方法

  摘要：

  碘诱导的2'-羟基查尔酮的氧化环化为各种羟基黄酮和类似物提供了一种简单，高效的方法。该过程在温和的条件下进行，可耐受各种官能团，并以良好至极好的收率提供羟基黄酮。烯丙基保护的苯乙酮和苯甲醛在相似条件下被平滑脱醛。

  DOI：

  10.1002/jhet.1580

文献信息

• Method and compositions for identifying anti-HIV therapeutic compounds
  申请人：GILEAD SCIENCES, INC.

  公开号：US20040121316A1

  公开（公告）日：2004-06-24

  Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.

  提供了一种鉴定含有羧酸酯或磷酸酯基团抗HIV治疗化合物的方法。可以选择使用新型酶GS-7340酯水解酶筛选这类化合物的文库。还提供了与GS-7340酯水解酶相关的组合物和方法。
• Novel compounds and methods for synthesis and therapy
  申请人：——

  公开号：US20040053999A1

  公开（公告）日：2004-03-18

  Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

  描述了新化合物。这些化合物通常包括一个酸性基团，一个碱性基团，一个取代氨基或N-酰基和一个具有可选择羟基化的烷基部分的基团。还描述了包括本发明的抑制剂的药物组合物。还描述了在疑似含有神经氨酸酶的样品中抑制神经氨酸酶的方法。还描述了抗原材料、聚合物、抗体、本发明化合物与标记物的结合物以及用于检测神经氨酸酶活性的测定方法。
• Novel chain-breaking antioxidants
  申请人：——

  公开号：US20020143025A1

  公开（公告）日：2002-10-03

  Compounds, preferably 5-pyrimidinol and 3-pyridinol derivatives, that act as effective chain breaking antioxidants of both the lipid and water-soluble variety (analogous to the natural Vitamins E and C), many of which are more reactive toward peroxyl radicals than the most potent form of Vitamin E. These compounds may exhibit many chemopreventive effects associated with conditions in which free radical-mediated cellular damage or disruption is implicated and Vitamins E and C are shown to have protective effects. Additionally, these compounds should be excellent oxidation inhibitors as additives to fuels, lubricants, rubber, polymers, chemicals, solvents and foodstuffs.

  化合物，最好是5-嘧啶醇和3-吡啶醇衍生物，作为有效的链断裂抗氧化剂，既可以溶解于脂质又可以溶解于水（类似于天然维生素E和C），其中许多对过氧自由基的反应性比最有效的维生素E形式更高。这些化合物可能展现出许多与自由基介导的细胞损伤或破坏相关的化学预防效应，而维生素E和C已经显示出具有保护作用。此外，这些化合物应该作为添加剂，对燃料、润滑剂、橡胶、聚合物、化学品、溶剂和食品等具有出色的氧化抑制作用。
• Process for the preparation of rhodamines
  申请人：TAOKA CHEMICAL CO., LTD

  公开号：EP0468821A1

  公开（公告）日：1992-01-29

  A process for preparing rhodamines represented by the following general formula (I) or (II): wherein R₁, R₂, and R₃ are independently hydrogen or a lower alkyl, group, but R₁ and R₂ are not both hydrogen which comprises subjecting phthalic anhydride and N-substituted-m-aminophenols represented by the following general formula (III): wherein R₁, R₂, and R₃ have the above-described meanings, to condensation reaction in one or more organic solvents selected from the group consisting of halogentated and/or alkylated aromatic hydrocarbons or aliphatic hydrocarbons.

  一种制备以下一般式（I）或（II）所代表的罗丹明的方法：其中R₁、R₂和R₃独立地为氢或较低的烷基，但R₁和R₂不同时为氢，该方法包括将邻苯二甲酸酐和以下一般式（III）所代表的N-取代的间氨基酚进行缩合反应，其中R₁、R₂和R₃具有上述所述的含义，在从卤代芳烃和/或烷基芳烃或脂肪烃组成的有机溶剂中进行。
• Allylation of Alcohols and Carboxylic Acids with Allyl Acetate Catalyzed by [Ir(cod)₂]⁺BF₄^- Complex
  作者：Hideto Nakagawa、Tomotaka Hirabayashi、Satoshi Sakaguchi、Yasutaka Ishii

  DOI：10.1021/jo049828k

  日期：2004.5.1

  allyl acetate was developed by the use of [Ir(cod)2]+BF4- complex. For instance, the reaction of allyl acetate with n-octyl alcohol in the presence of a catalytic amount of [Ir(cod)2]+BF4- complex afforded allyl octyl ether in quantitative yield. Allyl carboxylates were also prepared by the exchange reaction between carboxylic acids and allyl acetate in good yields. The [Ir(cod)2]+BF4- complex catalyzed

  对于烯丙基烷基醚的从与乙酸烯丙基酯的醇合成一种简便方法是通过使用开发的[Ir（COD）2 ] + BF 4 -复合物。例如，乙酸烯丙酯的反应与Ñ辛基醇在催化量的存在下的[Ir（COD）2 ] + BF 4 -复杂，得到烯丙基辛基醚，定量产率。还通过羧酸和乙酸烯丙酯之间的交换反应以高收率制备羧酸烯丙酯。所述的[Ir（COD）2 ] + BF 4 - 该配合物催化烷基胺和芳族胺与乙酸烯丙酯的反应，以公平至良好的收率得到相应的烯丙基胺。