p-(di-n-hexylamino)phenol | 1351044-01-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: p-(di-n-hexylamino)phenol
• 英文别名: 4-(dihexylamino)phenol
• CAS: 1351044-01-3
• 化学式: C₁₈H₃₁NO
• 分子量: 277.45
• InChiKey: OXRWRKPAPJXZIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  p-(di-n-hexylamino)phenol 、 IR-820 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以48%的产率得到sodium 4-(2-((E)-2-((E)-2-(4-(dihexyamino)phenoxy)-3-((E)-2-(1,1-dimethyl-3-(4-sulfonatobutyl)-1H-benzo[e]indol-2(3H)-ylidene)ethylidene)cyclohexenyl)vinyl)-1,1-dimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate
  参考文献：
  名称：

  Fluorescent Probe for Imaging Lymph Nodes

  摘要：

  本发明公开了一种近红外荧光成像剂，包括靛青基荧光染料和脂质体。本发明的近红外荧光成像剂在哨兵淋巴结中表现出高荧光强度和长时间锚定，因此可用于检测哨兵淋巴结导航手术中的哨兵淋巴结。本发明还公开了一种靛青绿衍生物，特别适用于本发明的近红外荧光成像剂。

  公开号：

  US20130129631A1
• 作为产物：
  描述：

  对氨基苯酚 、 1-碘己烷 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 9.0h， 以58%的产率得到p-(di-n-hexylamino)phenol
  参考文献：
  名称：

  Fluorescent Probe for Imaging Lymph Nodes

  摘要：

  本发明公开了一种近红外荧光成像剂，包括吲哚菁绿类荧光染料和脂质体。本发明的近红外荧光成像剂在哨兵淋巴结中表现出高荧光强度和长时间的锚定，因此适用于在哨兵淋巴结导航手术中检测哨兵淋巴结。本发明还公开了一种吲哚菁绿衍生物，特别适用于本发明的近红外荧光成像剂中使用。

  公开号：

  US20160222211A1

文献信息

• 안료-염료 분산체, 이 분산체로부터 제조되는 녹색 컬러필터 및 디스플레이 장치
  申请人：LG Display Co.,Ltd. 엘지디스플레이 주식회사(119981018655) Corp. No ▼ 110111-0393134

  公开号：KR20170064178A

  公开（公告）日：2017-06-09

  본 발명은 녹색 염료, 상기 녹색 염료를 함유하는 안료-염료 분산체, 상기 안료-염료 분산체를 함유하는 레지스트 조성물, 상기 레지스트 조성물의 경화에 의해 얻어지는 색소를 함유하는 녹색 컬러필터 및 녹색 컬러필터를 포함하는 디스플레이 장치에 관한 것이다. 본 발명의 안료-염료 분산체는 안료 및 염료가 혼합되어 내열 특성 및 내광 특성이 우수하고, 레지스트 공정, 노광 공정 및 세정 공정에서 사용되는 용매에 대한 내-화학적 특성이 개선되어 공정의 신뢰성을 향상시킬 수 있다. 뿐만 아니라, 본 발명의 안료-염료 분산체로부터 제조되는 색소는 콘트라스트비가 개선되어, 우수한 품질의 컬러필터 및 디스플레이 장치에 적용될 수 있을 것으로 기대된다.

  本发明涉及一种绿色染料、含有该绿色染料的颜料-染料分散体、含有该颜料-染料分散体的光阻组合物、经该光阻组合物固化所得的含有色素的绿色滤光片以及包含该绿色滤光片的显示器件。本发明的颜料-染料分散体中，染料和颜料混合后具有优异的耐热性和耐光性，并且对于在光刻工艺、显影工艺和清洗工艺中使用的溶剂具有改进的耐化学性能，能够提高工艺的可靠性。此外，从本发明的颜料-染料分散体中制备的色素具有更好的对比度，可应用于优质的彩色滤光片和显示器件中。
• N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, And Composition For Transfer And Storage Of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound
  申请人：Shinohata Masaaki

  公开号：US20110133121A1

  公开（公告）日：2011-06-09

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明涉及一种从有机胺、碳酸衍生物和含有一种或多种羟基化合物中制得的N-取代氨基甲酸酯的制备方法，其中使用一种含有冷凝器的脲类生产反应容器反应有机胺、碳酸衍生物和羟基化合物，将含有羟基化合物的气体、来自碳酸衍生物衍生的含有羰基基团的化合物、以及在反应中形成的氨气体引入到脲类生产反应容器中的冷凝器中，使羟基化合物和含有羰基基团的化合物冷凝，其中在冷凝的羟基化合物中所含有的羟基化合物与冷凝的含有羰基基团的化合物中所含有的羰基基团的化合物的比例为1或更多，而且在从冷凝器中回收的氨气体中所含有的羰基基团（—C(═O)—）数与氨分子数的比例为1或更少。
• N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, and Composition for Transfer and Storage of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound
  申请人：Asahi Kasei Chemicals Corporation

  公开号：US20140194650A1

  公开（公告）日：2014-07-10

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明是一种从有机胺、碳酸酯衍生物和含有一种或多种羟基化合物中制备N-取代的氨基甲酸酯的方法，其中利用一种尿素生产反应容器反应有机胺、碳酸酯衍生物和羟基化合物，该反应容器配有冷凝器，将含有羟基化合物的气体、由碳酸酯衍生物产生的含有羰基基团的化合物以及在反应中生成的氨引入到尿素生产反应容器中的冷凝器中，将羟基化合物和含有羰基基团的碳酸酯衍生物冷凝，其中在冷凝的羟基化合物中所含的羟基化合物的化学计量比与所冷凝的含有羰基基团的化合物的化学计量比为1或更多，而且所含有羰基基团的化合物中所含的羰基基团（-C(═O)-）的数量与从冷凝器中回收的氨分子数量的比率为1或更小。
• FLUORESCENT PROBE FOR IMAGING LYMPH NODES
  申请人：National University Corporation Chiba University

  公开号：EP2579027A1

  公开（公告）日：2013-04-10

  Disclosed is a near-infrared fluorescent imaging agent comprising an indocyanine-based fluorescent dye and a liposome. The near-infrared fluorescent imaging agent of the present invention demonstrates high fluorescence intensity and a long anchoring time in sentinel lymph nodes, thereby making it useful for detecting sentinel lymph nodes in sentinel lymph node navigation surgery. Also disclosed is an indocyanine green derivative that is particularly suitable for use in the near-infrared fluorescent imaging agent of the present invention.

  本发明公开了一种近红外荧光成像剂，由吲哚菁基荧光染料和脂质体组成。本发明的近红外荧光成像剂在前哨淋巴结中显示出较高的荧光强度和较长的锚定时间，因此可用于前哨淋巴结导航手术中检测前哨淋巴结。本发明还公开了一种吲哚菁绿衍生物，它特别适用于本发明的近红外荧光成像剂。
• METHOD FOR PRODUCING N-SUBSTITUTED CARBAMIC ACID ESTER
  申请人：ASAHI KASEI KABUSHIKI KAISHA

  公开号：EP3153499A1

  公开（公告）日：2017-04-12

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (-C(=O)-) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明是一种用有机胺、碳酸衍生物和含有一种或多种羟基化合物的羟基组合物生产由有机胺衍生的N-取代氨基甲酸酯的方法，其中有机胺、碳酸衍生物和羟基组合物在一个装有冷凝器的氨基甲酸乙酯生产反应釜中反应、使用配备有冷凝器的聚氨酯生产反应容器对碳酸衍生物和羟基组合物进行反应，将含有羟基组合物、从碳酸衍生物衍生出的具有羰基的化合物以及在反应中作为副产物形成的氨的气体引入聚氨酯生产反应容器中的冷凝器、缩合羟基组合物和具有碳酸衍生物衍生的羰基的化合物，其中缩合羟基组合物中所含的羟基化合物与具有碳酸衍生物衍生的羰基的缩合化合物的化学计量比为 1 或以上、且具有碳酸衍生物衍生的羰基的化合物中所含的羰基数（-C(=O)-）与从冷凝器中作为气体回收的氨中所含的氨分子数之比为 1 或更少。