N-[5-(2-chlorophenyl)-2-furoyl]-N'-(4-bromophenyl)thiourea | 289892-60-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[5-(2-chlorophenyl)-2-furoyl]-N'-(4-bromophenyl)thiourea
• 英文别名: N-[(4-bromophenyl)carbamothioyl]-5-(2-chlorophenyl)furan-2-carboxamide
• CAS: 289892-60-0
• 化学式: C₁₈H₁₂BrClN₂O₂S
• 分子量: 435.728
• InChiKey: CBJKTMOGUNVDDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  86.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-[5-(2-chlorophenyl)-2-furoyl]-N'-(4-bromophenyl)thiourea 在 potassium iodate 作用下， 以 水 为溶剂， 反应 1.0h， 以89%的产率得到N-[5-(2-chlorophenyl)-2-furoyl]-N'-(4-bromophenyl)urea
  参考文献：
  名称：

  A Novel Route to Acyl Ureas: Syntheses of N-[5-(2-Chlorophenyl)-2-Furoyl]-N'-Arylthioureas and Ureas

  摘要：

  A novel route to acyl ureas is described. Reaction of 5-(2-chlorophenyl)-2-furoyl chloride with ammonium thiocyanate first, then arylamine under phase transfer catalysis gives N-[5-(2-chlorophenyl)-2-furoyl]-N'-aryl-thioureas (1a-o). Compounds 1a-o on oxidation with potassium iodate respectively under reflux result in the formation of N-[5-(2-chlorophenyl)-2-furoyl-N'-arylureas (2a-o).

  DOI：

  10.1080/00397910008087430
• 作为产物：
  描述：

  5-(2-chlorophenyl)-2-furoyl chloride 在 PEG-400 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 生成 N-[5-(2-chlorophenyl)-2-furoyl]-N'-(4-bromophenyl)thiourea
  参考文献：
  名称：

  A Novel Route to Acyl Ureas: Syntheses of N-[5-(2-Chlorophenyl)-2-Furoyl]-N'-Arylthioureas and Ureas

  摘要：

  A novel route to acyl ureas is described. Reaction of 5-(2-chlorophenyl)-2-furoyl chloride with ammonium thiocyanate first, then arylamine under phase transfer catalysis gives N-[5-(2-chlorophenyl)-2-furoyl]-N'-aryl-thioureas (1a-o). Compounds 1a-o on oxidation with potassium iodate respectively under reflux result in the formation of N-[5-(2-chlorophenyl)-2-furoyl-N'-arylureas (2a-o).

  DOI：

  10.1080/00397910008087430

文献信息

• A Novel Route to Acyl Ureas: Syntheses of N-[5-(2-Chlorophenyl)-2-Furoyl]-N'-Arylthioureas and Ureas
  作者：Zheng Li、Xicun Wang、Yuxia Da、Jichou Chen

  DOI：10.1080/00397910008087430

  日期：2000.7

  A novel route to acyl ureas is described. Reaction of 5-(2-chlorophenyl)-2-furoyl chloride with ammonium thiocyanate first, then arylamine under phase transfer catalysis gives N-[5-(2-chlorophenyl)-2-furoyl]-N'-aryl-thioureas (1a-o). Compounds 1a-o on oxidation with potassium iodate respectively under reflux result in the formation of N-[5-(2-chlorophenyl)-2-furoyl-N'-arylureas (2a-o).