diethyl (1-(4-fluorobenzyl) pyrrolidin-2-yl)phosphonate | 1449563-42-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl (1-(4-fluorobenzyl) pyrrolidin-2-yl)phosphonate
• 英文别名: 2-Diethoxyphosphoryl-1-[(4-fluorophenyl)methyl]pyrrolidine；2-diethoxyphosphoryl-1-[(4-fluorophenyl)methyl]pyrrolidine
• CAS: 1449563-42-1
• 化学式: C₁₅H₂₃FNO₃P
• 分子量: 315.325
• InChiKey: BLMDLTGEIIBXSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对氟苯甲醛 、 diethyl phosphite 、 DL-脯氨酸 以 甲苯 为溶剂， 反应 5.0h， 以65%的产率得到diethyl (1-(4-fluorobenzyl) pyrrolidin-2-yl)phosphonate
  参考文献：
  名称：

  A catalyst-free, three-component decarboxylative coupling of amino acids with aldehydes and H-dialkylphosphites for the synthesis of α-aminophosphonates

  摘要：

  A simple, efficient, and new method is developed for the synthesis of alpha-aminophosphonates via a three-component, catalyst-free decarboxylative coupling of amino acids with aldehydes and H-dialkyl phosphite. Treatment of amino acids with aldehydes and diethyl phosphite in the absence of catalyst, base, and ligand give alpha-aminophosphonates in moderate to good yields. This method is simple, rapid, and high-yielding. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.129

文献信息

• A catalyst-free, three-component decarboxylative coupling of amino acids with aldehydes and H-dialkylphosphites for the synthesis of α-aminophosphonates
  作者：Babak Kaboudin、Leila Karami、Jun-ya Kato、Hiroshi Aoyama、Tsutomu Yokomatsu

  DOI：10.1016/j.tetlet.2013.06.129

  日期：2013.9

  A simple, efficient, and new method is developed for the synthesis of alpha-aminophosphonates via a three-component, catalyst-free decarboxylative coupling of amino acids with aldehydes and H-dialkyl phosphite. Treatment of amino acids with aldehydes and diethyl phosphite in the absence of catalyst, base, and ligand give alpha-aminophosphonates in moderate to good yields. This method is simple, rapid, and high-yielding. (C) 2013 Elsevier Ltd. All rights reserved.