Oxo-phenyl-acetic acid (1R,2S,3R,4S)-1,7,7-trimethyl-3-(toluene-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl ester | 146310-99-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Oxo-phenyl-acetic acid (1R,2S,3R,4S)-1,7,7-trimethyl-3-(toluene-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl ester
• 英文别名: [(1R,2S,3R,4S)-1,7,7-trimethyl-3-[(4-methylphenyl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl] 2-oxo-2-phenylacetate
• CAS: 146310-99-8
• 化学式: C₂₅H₂₉NO₅S
• 分子量: 455.575
• InChiKey: DISDWFSACJQNQC-SMISUXHESA-N

物化性质

• 沸点：
  571.8±60.0 °C(predicted)
• 密度：
  1.29±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  97.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Oxo-phenyl-acetic acid (1R,2S,3R,4S)-1,7,7-trimethyl-3-(toluene-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl ester 在 lithium hydroxide 、 LiAlH(OCEt₃)3 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 2.0h， 生成 D-扁桃酸
  参考文献：
  名称：

  .alpha.-(Arylsulfonamido)borneols as auxiliaries in asymmetric synthesis: an efficient and highly stereoselective method for the reduction of .alpha.-keto esters

  摘要：

  A method for preparation of enantiomerically pure alpha-hydroxy esters by stereoselective reduction of chiral alpha-keto esters under convenient conditions (LiAlH(OCEt3)3, THF,0-degrees-C) has been developed. The compounds exo,exo-3-(arylsulfonamido)-2-borneol and exo,exo-2-(arylsulfonamido)-3-borneol have been used as novel auxiliaries to achieve highly diastereoselective reductions. The auxiliaries can be removed by mild saponification (LiOH, THF-H2O, rt) without racemization of the reduced products.

  DOI：

  10.1021/jo00057a004
• 作为产物：
  描述：

  3-氨基-1,7,7-三甲基-双环[2,2,1]庚-2-醇 在 吡啶 、 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 Oxo-phenyl-acetic acid (1R,2S,3R,4S)-1,7,7-trimethyl-3-(toluene-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl ester
  参考文献：
  名称：

  .alpha.-(Arylsulfonamido)borneols as auxiliaries in asymmetric synthesis: an efficient and highly stereoselective method for the reduction of .alpha.-keto esters

  摘要：

  A method for preparation of enantiomerically pure alpha-hydroxy esters by stereoselective reduction of chiral alpha-keto esters under convenient conditions (LiAlH(OCEt3)3, THF,0-degrees-C) has been developed. The compounds exo,exo-3-(arylsulfonamido)-2-borneol and exo,exo-2-(arylsulfonamido)-3-borneol have been used as novel auxiliaries to achieve highly diastereoselective reductions. The auxiliaries can be removed by mild saponification (LiOH, THF-H2O, rt) without racemization of the reduced products.

  DOI：

  10.1021/jo00057a004