7,8-dichloro-1,2,3,4-tetrahydro-benzo[4,5]imidazo[1,2-a]pyridine | 59504-40-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 7,8-dichloro-1,2,3,4-tetrahydro-benzo[4,5]imidazo[1,2-a]pyridine
• 英文别名: 7,8-Dichlor-1,2,3,4-tetrahydro-pyridino<1,2-a>benzimidazol；7,8-Dichlor-1,2,3,4-tetrahydro-pyrido<1,2-a>benzimidazol；7,8-Dichloro-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole；7,8-dichloro-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole
• CAS: 59504-40-4
• 化学式: C₁₁H₁₀Cl₂N₂
• 分子量: 241.12
• InChiKey: BWVDTFSHKDUQFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4,5-二氯邻苯二胺 、 戊二醛 在 甲酸 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以62%的产率得到7,8-dichloro-1,2,3,4-tetrahydro-benzo[4,5]imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Metal-free construction of tricyclic or tetracyclic compounds—acid-promoted synthesis of benzo[4,5]imidazo[2,1-a]isoindole and 1,2-dialkyl-2,3-dihydrobenzimidazoles

  摘要：

  An environmental friendly, efficient, and easy to operate strategy for synthesizing of benzo[4,5]imidazo [2,1-a]isoindole and 1,2-dialkyl-2,3-dihydrobenzimidazoles via acid-promoted coupling of dialdehyde and o-diaminobenzene under metal-free conditions is described. A series of products were generated in good yields under mild conditions. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.10.030

文献信息

• Metal-free construction of tricyclic or tetracyclic compounds—acid-promoted synthesis of benzo[4,5]imidazo[2,1-a]isoindole and 1,2-dialkyl-2,3-dihydrobenzimidazoles
  作者：Jinying Chen、Jinpeng Qu、Yuanqing Zhang、Yongxin Chen、Na Liu、Baohua Chen

  DOI：10.1016/j.tet.2012.10.030

  日期：2013.1

  An environmental friendly, efficient, and easy to operate strategy for synthesizing of benzo[4,5]imidazo [2,1-a]isoindole and 1,2-dialkyl-2,3-dihydrobenzimidazoles via acid-promoted coupling of dialdehyde and o-diaminobenzene under metal-free conditions is described. A series of products were generated in good yields under mild conditions. (C) 2012 Elsevier Ltd. All rights reserved.