N-trimellitylimido-L-leucine | 126296-64-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-trimellitylimido-L-leucine
• 英文别名: 2-[(1S)-1-carboxy-3-methylbutyl]-1,3-dioxoisoindole-5-carboxylic acid
• CAS: 126296-64-8；131613-54-2
• 化学式: C₁₅H₁₅NO₆
• 分子量: 305.287
• InChiKey: MLBQKULJXDHKHT-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-trimellitylimido-L-leucine 生成 methyl 2-[(2S)-1-methoxy-4-methyl-1-oxopentan-2-yl]-1,3-dioxoisoindole-5-carboxylate
  参考文献：
  名称：

  KORA, F. A.;EL-HADDAD, A. F.;COMMAA, A. M.;ABOUU, EL-ABBAS M. A.;EL-NAGGA+, J. SERB. CHEM. SOC., 55,(1990) N, C. 257-263

  摘要：

  DOI：
• 作为产物：
  描述：

  生成 N-trimellitylimido-L-leucine
  参考文献：
  名称：

  4,4'-硫代双（2-叔丁基-5-甲基苯酚）与手性二酸的直接缩合反应合成具有氨基酸部分的光学活性纳米结构聚合物

  摘要：

  通过偏苯三酸酐（1）与乙酸中的1-氨基酸（2a-2d）作为二元酸单体反应，制备了N -trimellitylimido- 1-氨基酸（4a-4d）的四种衍生物，并用于此目的。获得基于氨基酸的聚（酯酰亚胺）（PEI）的新家族。聚合反应是在甲苯磺酰氯（TsCl），吡啶和N存在下，将手性二元酸（4a-4d）与4,4'-硫代双（2-叔丁基-5-甲基苯酚）（5）直接缩聚进行的， ñ-二甲基甲酰胺（DMF）。通过改变加热时间进行逐步生长聚合，并且达到TsCl /二酸的摩尔比并达到最佳条件。借助特定的旋转实验，FT-IR，1 H-NMR，X射线衍射技术和元素分析对合成的聚合物进行了表征。通过场发射扫描电子显微镜研究获得的聚合物的表面形态。结果显示了所得聚合物的纳米结构形态。所得PEI可溶于极性非质子溶剂，例如DMF，N，N-二甲基乙酰胺，二甲基亚砜，N-甲基-2-吡咯烷酮和质子溶剂，例如硫酸。通过热重分

  DOI：

  10.1007/s00726-011-0958-3

文献信息

• Sonochemical Preparation and Characterization of Modified CuO Nanocrystalline With Bioactive Chiral Diacids Derived From Different Natural Amino Acids
  作者：Shadpour Mallakpour、Maryam Vahabi

  DOI：10.1080/15533174.2015.1137047

  日期：2016.11.1

  To improve the dispersion ability of CuO nanoparticles (NPs), their surface was modified by chiral diacids (DAs) containing amino acids. The surface modification process was achieved using ultrasonic irradiation. DA could be absorbed on the surface of CuO. The carboxyl groups of DA may interact with surface of CuO NPs and form covalent bond with it. Interactions between DAs and CuO NPs were investigated

  为了提高CuO纳米颗粒（NPs）的分散能力，其表面被含有氨基酸的手性二酸（DAs）改性。使用超声波辐照实现了表面改性过程。DA可以被吸收在CuO的表面上。DA的羧基可与CuO NP的表面相互作用并与其形成共价键。通过不同的技术研究了DA与CuO NP之间的相互作用。X射线衍射图证明，改性过程不会改变CuO的晶相。结果证实了有机官能团在NP表面上的成功沉积。
• Design of one-pot green protocol for the synthesis of novel modified LDHs with diacids based on amino acids: morphology and thermal examinations
  作者：Shadpour Mallakpour、Mohammad Dinari、Vajiheh Behranvand

  DOI：10.1007/s13738-016-0880-4

  日期：2016.9

  In this study, a simple, fast and environmentally friendly protocol has been proposed for the synthesis of layered double hydroxides (LDHs) and organomodified chiral LDHs under ultrasound irradiation as a green and fast tool for the first time. Novel chiral LDHs were synthesized in one step from the co-precipitation reaction of the Al(NO3)3·9H2O, Mg(NO3)2·6H2O and different bioactive N-trimellitylimido-l-amino

  在这项研究中，首次提出了一种简单，快速且对环境友好的方案，首次以绿色和快速的手段在超声辐射下合成层状双氢氧化物（LDH）和有机改性的手性LDH。从Al（NO 3）3 ·9H 2 O，Mg（NO 3）2 ·6H 2 O和不同的生物活性N -trimellitylimido- l的共沉淀反应一步合成了新型手性LDH。-氨基酸处于水性状态。通过诸如傅立叶变换红外光谱，X射线衍射，场发射扫描电子显微镜和透射电子显微镜技术的几种方法研究获得的材料。结构和形态分析的结果表明，LDH粘土夹层中成功插入了手性二酸。通过热重分析法研究热性能。结果表明，热分解过程中存在四个失重步骤。含有N -trimellitylimido二酸的氨基酸在修饰的LDH中创造了一种手性环境，可用于手性领域。
• An efficient and convenient protocol for the synthesis of optically active [1,2,4]triazolo[3,4-<i>b</i>][1,3,4]thiadiazole derivatives containing L-amino acid moieties
  作者：Naesr Foroughifar、Sattar Ebrahimi、Akbar Mobinikhaledi、Reza Mozafari

  DOI：10.1515/hc.2011.048

  日期：2011.12.1

  Abstract New triazolothiadiazoles bearing L-amino acid moieties were synthesized by reaction of 4-amino-5-phenoxy-4H-1,2,4-triazole-3-thiol with L-amino acids in the presence of phosphorus oxychloride.

  摘要 在磷酰氯存在下，4-氨基-5-苯氧基-4H-1,2,4-三唑-3-硫醇与L-氨基酸反应合成了带有L-氨基酸部分的新型三唑噻二唑。
• Hydrolytically degradable amino acid-containing polymers
  作者：Andrea Staubli、Eyal Ron、Robert Langer

  DOI：10.1021/ja00167a045

  日期：1990.5
• NANOSTRUCTURE FORMATION IN CHIRAL POLY(AMIDE-IMIDE)S BASED ON DOPAMINE MOIETY AND N-TRIMELLITYLIMIDO-L-AMINO ACIDS IN THE MAIN CHAIN
  作者：S MALLAKPOUR、A ZADEHNAZARI

  DOI：10.4067/s0717-97072012000300011

  日期：——

  Nanostructured poly(amide-imide) (PAI) materials have been produced by polymerizing a diamine monomer, 3,5-diamino-N-(3,4-dihydroxyphenethyl) benzamide, with four trimellitic anhydride-derived, imide ring-preformed chiral amino acid-based dicarboxylic acids. Polycondensation reactions were carried out in the presence of small amount of molten tetrabutylammonium bromide as a green molten salt medium and triphenyl phosphite as the activator by classical heating method. Field emission scanning electron microscopy micrographs showed that the prepared polymers are assembled by spherical particles, which are distributed uniformly and randomly, having nano-sized diameter ranged between 46-54 nm. According to X-ray diffraction patterns, all of PAIs are amorphous. They show excellent solubility in a variety of amide polar solvents and even in less polar solvents such as m-cresol and pyridine. The obtained PAIs were also characterized by Fourier transform infrared spectroscopy, H-1 NMR, elemental, and thermogravimetric analysis techniques. The effect of ultrasound on the morphology of polymers was also investigated. This study confirmed that the size of polymer particles was decreased and the shape of them was also changed.