5-biphen-4-yl-isoxazole-3-carboxylic acid | 109558-73-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-biphen-4-yl-isoxazole-3-carboxylic acid
• 英文别名: 5-biphenyl-4-yl-isoxazole-3-carboxylic acid；5-Biphenyl-4-yl-isoxazol-3-carbonsaeure；5-Biphenyl-4-ylisoxazole-3-carboxylic acid；5-(4-phenylphenyl)-1,2-oxazole-3-carboxylic acid
• CAS: 109558-73-8
• 化学式: C₁₆H₁₁NO₃
• 分子量: 265.268
• InChiKey: BNXVUFWYOPFLPL-UHFFFAOYSA-N

物化性质

• 沸点：
  546.1±38.0 °C(Predicted)
• 密度：
  1.271±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-biphen-4-yl-isoxazole-3-carboxylic acid 生成 5-biphenyl-4-yl-2-(4-nitro-phenyl)-2H-pyrazol-3-ylamine
  参考文献：
  名称：

  Fatutta; Balestra, Gazzetta Chimica Italiana, 1958, vol. 88, p. 899,907

  摘要：

  DOI：
• 作为产物：
  描述：

  2-hydroxy-4-oxo-4-(4-biphenylyl)but-2-enoic acid ethyl ester 在 盐酸羟胺 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 26.0h， 生成 5-biphen-4-yl-isoxazole-3-carboxylic acid
  参考文献：
  名称：

  New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis

  摘要：

  Growing evidence suggests a role for the endocannabinoid (EC) system, in intestinal inflammation and compounds inhibiting anandamide degradation offer a promising therapeutic option for the treatment of inflammatory bowel diseases. In this paper, we report the first series of carboxamides derivatives possessing FAAH inhibitory activities. Among them, compound 39 displayed significant inhibitory FAAH activity (IC50 = 0.088 mu M) and reduced colitis induced by intrarectal administration of TNBS. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.04.057

文献信息

• Synthesis and Evaluation as Antitubercular Agents of 5-Arylethenyl and 5-(Hetero)aryl-3-Isoxazolecarboxylate
  作者：Claudia Vergelli、Agostino Cilibrizzi、Letizia Crocetti、Alessia Graziano、Vittorio Dal Piaz、Baojie Wan、Yuehong Wang、Scott Franzblau、Maria Paola Giovannoni

  DOI：10.1002/ddr.21057

  日期：2013.5

  Preclinical Research

  临床前研究
• Fatutta; Balestra, Gazzetta Chimica Italiana, 1958, vol. 88, p. 899,907
  作者：Fatutta、Balestra

  DOI：——

  日期：——
• New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis
  作者：Virginie Andrzejak、Giulio G. Muccioli、Mathilde Body-Malapel、Jamal El Bakali、Madjid Djouina、Nicolas Renault、Philippe Chavatte、Pierre Desreumaux、Didier M. Lambert、Régis Millet

  DOI：10.1016/j.bmc.2011.04.057

  日期：2011.6

  Growing evidence suggests a role for the endocannabinoid (EC) system, in intestinal inflammation and compounds inhibiting anandamide degradation offer a promising therapeutic option for the treatment of inflammatory bowel diseases. In this paper, we report the first series of carboxamides derivatives possessing FAAH inhibitory activities. Among them, compound 39 displayed significant inhibitory FAAH activity (IC50 = 0.088 mu M) and reduced colitis induced by intrarectal administration of TNBS. (C) 2011 Elsevier Ltd. All rights reserved.