(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;2-hydroxyethanesulfonic acid | 72099-66-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;2-hydroxyethanesulfonic acid
• CAS: 72099-66-2
• 化学式: C24H36Cl2N10O4S
• 分子量: 631.6
• InChiKey: CWSMRTFHJRMZCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  41
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  261
• 氢给体数：
  8
• 氢受体数：
  6

文献信息

• Rapid surface disinfection method and apparatus
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US10632217B2

  公开（公告）日：2020-04-28

  A device for rapidly sanitizing a surface is described. The device has an enclosure having an opening adapted to insert a surface, and an interior; a liquid nitric oxide solution applicator; and an absorbent material. The liquid nitric oxide solution applicator is in fluid communication with the interior of the enclosure and is adapted to apply liquid nitric oxide solution onto the surface when the surface is positioned within the enclosure. A method of rapidly sanitizing a surface is described. The devices and methods provided herein may be implemented to sanitize the surface of any body part or item that may be placed within the device. An infectious agent on the surface may be killed; i.e., the surface is disinfected. Non-limiting applications of the devices and methods include preventing nosocomial infections or food contamination, sanitizing household items, and implementing sanitizing procedures to comply with FDA Good Manufacturing Practices.

  描述了一种用于快速消毒表面的装置。该装置有一个外壳，其开口适于插入一个表面和一个内部；一个液态一氧化氮溶液涂抹器；以及一种吸收材料。液态一氧化氮溶液涂抹器与外壳内部流体相通，当表面位于外壳内时，液态一氧化氮溶液涂抹器可将液态一氧化氮溶液涂抹到表面上。描述了一种快速消毒表面的方法。本文提供的设备和方法可用于对任何身体部位或放置在设备内的物品的表面进行消毒。表面上的传染性病原体可能会被杀死，即表面被消毒。这些装置和方法的非限制性应用包括预防非医院感染或食品污染、消毒家用物品，以及实施符合美国食品及药物管理局良好生产规范的消毒程序。
• Kit and method for topical delivery of benefits
  申请人：Johnson & Johnson Consumer Inc.

  公开号：US10821297B2

  公开（公告）日：2020-11-03

  A system for delivering energy to an isolated part of a mammalian body includes an electrically powered patch and a self-supporting adhesive film. The patch has a major surface and comprises a matrix of at least one flexible, biocompatible material which is capable of conforming to the isolated body part. The self-supporting adhesive film has a first non-tacky surface arranged and configured for releasable attachment to the patch and a second tacky surface, opposite the first surface, for adhesive attachment to the isolated body part. The releasable attachment between the self-supporting adhesive film and the electrically powered patch has a lower strength than the adhesive attachment between the film and the isolated body part. Thus, during use the electrically powered patch is removable from the self-supporting adhesive film while leaving the self-supporting adhesive film adhered to the isolated body part.

  一种向哺乳动物身体的孤立部位输送能量的系统包括一个电动贴片和一个自支撑胶膜。贴片有一个主要表面，由至少一种柔性生物相容性材料构成，能够贴合被隔离的身体部位。自支撑胶膜有一个第一非粘性表面，用于可释放地附着在贴片上，还有一个与第一表面相对的第二粘性表面，用于粘附在被隔离的身体部位上。自支撑胶膜与电动贴片之间的可释放附着强度低于胶膜与被隔离身体部位之间的粘附强度。因此，在使用过程中，通电贴片可从自支撑胶膜上取下，而自支撑胶膜仍粘附在被隔离的身体部位上。
• Composition for transdermal delivery of cationic active agents
  申请人：LTS Lohmann Therapie-Systeme AG

  公开号：US10881607B2

  公开（公告）日：2021-01-05

  The invention relates to a composition for transdermal delivery, particularly iontophoretic transdermal delivery, of at least one cationic active agent or a salt thereof. The composition includes at least one cationic active agent or a salt thereof, at least one polyamine or/and polyamine salt, water or an aqueous solvent mixture, and optionally one or more additives. The invention further relates to the use of such composition as a component of a transdermal patch or of an iontophoretic transdermal patch, as well as to the use of such composition in a method for transdermally and/or iontophoretically administering cationic active agents. The invention further includes methods for determining the in vitro skin permeation properties of an active-agent-containing iontophoretic composition.

  本发明涉及至少一种阳离子活性剂或其盐的透皮给药组合物，特别是离子透皮给药组合物。该组合物包括至少一种阳离子活性剂或其盐、至少一种多胺或/和多胺盐、水或水性溶剂混合物，以及可选的一种或多种添加剂。本发明还涉及将这种组合物用作透皮贴剂或离子透皮贴剂的成分，以及将这种组合物用于阳离子活性剂的透皮和/或离子透皮给药方法。本发明还包括确定含活性剂的离子透皮组合物的体外皮肤渗透特性的方法。
• System for targeted application of topical agents to an isolated body part
  申请人：JOHNSON & JOHNSON CONSUMER INC.

  公开号：US10842242B2

  公开（公告）日：2020-11-24

  A system includes an applicator mask having an applicator surface having a three-dimensional shape corresponding to the isolated body part; and at least one membrane releasably disposed on the applicator surface and having an outer surface in facing relation with the applicator surface and inner adhesive surface opposite thereof. The membrane includes one or more benefit agents disposed in one or more treatment zones.

  一种系统包括一个涂抹器面罩，其涂抹器表面具有与被隔离的身体部位相对应的三维形状；以及至少一个可释放地设置在涂抹器表面上的薄膜，该薄膜具有与涂抹器表面面对的外表面和与其相对的内粘合表面。膜包括一种或多种益处剂，分布在一个或多个治疗区内。
• Organic LED light and ultrasonic transducer device in a flexible layer configuration with electrical stimulation
  申请人：CAREWEAR CORP.

  公开号：US11083619B2

  公开（公告）日：2021-08-10

  A flexible device having a layered structure for delivering electrical stimulation and one or both of light and ultrasound to a skin surface is provided. The device is flexible so as to form a non-planar contact surface against the skin surface, and includes one or both of (a) a flexible light emitter layer positioned between two flexible conductive layers that emits light when driven by a power source and (b) a flexible ultrasound emitter layer positioned between two flexible conductive layers that produces ultrasound when driven by a power source. The device also includes a flexible electrical stimulation layer that functions as an electrode and is configured to provide electrical stimulation when driven by a power source.

  本发明提供了一种具有分层结构的柔性装置，用于向皮肤表面提供电刺激以及光和超声波中的一种或两种刺激。该装置具有柔性，可形成与皮肤表面的非平面接触面，并包括以下两者中的一个或两个：(a) 位于两个柔性导电层之间的柔性光发射器层，在电源驱动下发射光；(b) 位于两个柔性导电层之间的柔性超声波发射器层，在电源驱动下产生超声波。该装置还包括一个柔性电刺激层，该层可用作电极，在电源驱动时可提供电刺激。