1,2-distearoyl-sn-glycero-3-phosphoethanolamine sodium salt | 677741-94-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine sodium salt
• 英文别名: Dspe sodium, L-；sodium;2-aminoethyl [(2R)-2,3-di(octadecanoyloxy)propyl] phosphate
• CAS: 677741-94-5
• 化学式: C₄₁H₈₁NO₈P*Na
• 分子量: 770.06
• InChiKey: UZRCZWUJHJVEFD-DRRLCDGFSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  8.43
• 重原子数：
  52
• 可旋转键数：
  43
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  137
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  1,2-distearoyl-sn-glycero-3-phosphoethanolamine sodium salt 在 N-羟基丁二酰亚胺 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 甲醇 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 73.0h， 生成
  参考文献：
  名称：

  一种含有唾液酸基团的脂质衍生物的合成及 其在药物制剂中的应用

  摘要：

  本发明提供了一种可广泛用于微粒制剂修饰的含有唾液酸基团的脂质衍生物，具有式（1）所描述的结构:（1）并且其中的R1代表‑OH，‑HNCOCH3，‑NHCOCH2OH中的一种；HN‑R2‑S片段来自SH‑R2‑NH2，SH‑R2‑NH2是含有伯胺基团和巯基基团的化合物；R3片段来自含有α，β‑不饱和共轭羰基的化合物；R4片段来自R4‑H，R4‑H是含有羟基或伯胺基团的化合物。本发明提供的含有唾液酸基团的脂质衍生物可以用于多种微粒制剂的表面修饰，并赋予所修饰制剂靶向分布的能力。

  公开号：

  CN106188169B

文献信息

• Particulate Delivery Vehicles for Embryoid Bodies
  申请人：Ferreira Lino da Silva

  公开号：US20090263359A1

  公开（公告）日：2009-10-22

  The present invention provides a vehicle for delivering various chemicals, compositions and proteins to stem cells and embryoid bodies. The vehicle may be biocompatible and biodegradable polymer microparticles. Typically the particles will contain at least a growth factor for delivery to the embryoid bodies, and generally the growth factor induces differentiation of the cells in the embryoid body along a specific lineage. The present invention also provides methods for directing differentiation of the cells in the embryoid body.
• DRUG DELIVERY SYSTEM FOR PHARMACEUTICALS AND RADIATION
  申请人：Wang Zhuang

  公开号：US20110027172A1

  公开（公告）日：2011-02-03

  The present invention provides a drug delivery system for delivery of an agent and a radiopharmaceutical agent. The drug delivery system may specifically target an organ, tissue, cells, extracellular matrix, or intracellular compartment. Typically, the drug delivery system is a particle. Pharmaceutical compositions comprising the inventive particles are also provided. The present invention provides methods of preparing and using the inventive particles and pharmaceutical compositions. The inventive particles are useful in treating and diagnosing a variety of diseases including cancer. The inventive particles are also useful in tracking particles in vivo.
• US8642333B2
  申请人：——

  公开号：US8642333B2

  公开（公告）日：2014-02-04
• [EN] DRUG DELIVERY SYSTEM FOR PHARMACEUTICALS AND RADIATION<br/>[FR] SYSTÈME D'ADMINISTRATION DE MÉDICAMENT POUR PRODUITS PHARMACEUTIQUES ET RADIOPHARMACEUTIQUES
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2009110939A2

  公开（公告）日：2009-09-11

  The present invention provides a drug delivery system for delivery of an agent and a radiopharmaceutical agent. The drug delivery system may specifically target an organ, tissue, cells, extracellular matrix, or intracellular compartment. Typically, the drug delivery system is a particle. Pharmaceutical compositions comprising the inventive particles are also provided. The present invention provides methods of preparing and using the inventive particles and pharmaceutical compositions. The inventive particles are useful in treating and diagnosing a variety of diseases including cancer. The inventive particles are also useful in tracking particles in vivo.
• [EN] PARTICULATE DELIVERY VEHICLES FOR EMBRYOID BODIES<br/>[FR] VÉHICULES D'ADMINISTRATION DE PARTICULES POUR DES CORPS EMBRYOÏDES
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2009100128A1

  公开（公告）日：2009-08-13

  The present invention provides a vehicle for deliverying various chemicals, compositions and proteins to stem cells and embryoid bodies. The vehicle may be biocompatible and biodegradible polymer microparticles. Typically the particles will contain at least a growth factor for delivery to the embryoid bodies,, and generally the growth factor induces differentiation of the cells in the embryoid body along a specific lineage. The present invention also provides methods for directing differentiation of the cells in the embryoid body.