3,3'-carbonyldi(benzenesulfonyl chloride) | 17619-15-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3'-carbonyldi(benzenesulfonyl chloride)
• 英文别名: benzophenone-3,3'-bis-(sulphonylchloride)；3,3'-benzophenone-di(sulfonyl chloride)；Benzophenone-3,3'-disulfonyl chloride；3,3'-carbonyl-bis-benzenesulfonyl chloride；3,3'-Carbonyl-bis-benzolsulfonylchlorid；3,3'-Benzophenondisulfonyldichlorid；3-(3-Chlorosulfonylbenzoyl)benzenesulfonyl chloride
• CAS: 17619-15-7
• 化学式: C₁₃H₈Cl₂O₅S₂
• 分子量: 379.242
• InChiKey: PHTZHGNBMWRQNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,3'-carbonyldi(benzenesulfonyl chloride) 在 吡啶 、 一水合肼 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 10.0h， 生成
  参考文献：
  名称：

  Zaky; Mohamed; Nail, Egyptian Journal of Chemistry, 2004, vol. 47, # 3, p. 321 - 331

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 五氯化磷 作用下， 生成 3,3'-carbonyldi(benzenesulfonyl chloride)
  参考文献：
  名称：

  Lapworth, Journal of the Chemical Society, 1898, vol. 73, p. 408

  摘要：

  DOI：

文献信息

• A.C; A′.C′-doubly capped δ-cyclodextrin. Direct evidence for the capping structure
  作者：Iwao Tabushi、Lung Chi Yuan、Kazuhiro Shimokawa、Kan-ichi Yokota、Tadashi Mizutani、Yasuhisa Kuroda

  DOI：10.1016/s0040-4039(01)92908-9

  日期：——

  Doubly capped β-cyclodextrin was firstly prepared in good yield by the treatment of β- cyclodextrin with an excess amount (2.6/1 mol/mol) of benzophenone-3,3′-disulfonyl chloride. This successful double capping demonstrates that benzophenone-3,3′-disulfonyl capping takes place on A,C rings. The present double cap is a useful key intermediate for the preparation of regiospecifically tetrasubstituted

  首先通过用过量（2.6 / 1 mol / mol）二苯甲酮-3,3'-二磺酰氯处理β-环糊精以高收率制备双封端的β-环糊精。这种成功的双重封端证明了在A，C环上发生了二苯甲酮-3,3'-二磺酰基封端。本发明的双帽是用于制备区域特异性四取代的环糊精的有用的关键中间体。
• Biocleavable micelle compositions for use as drug carriers
  申请人：——

  公开号：US20010021703A1

  公开（公告）日：2001-09-13

  This invention discloses compositions and methods for preparing biocleavable or biodegradable micelle compositions for carrying and releasing drugs and other active agents for therapeutic or other medical uses. Methods are also disclosed for preparing biocleavable cyclodextrin micelle carriers that release drugs under controlled conditions. The invention also discloses biocleavable or biodegradable micelle compositions that are coupled to biorecognition molecules for targeting the delivery of drugs to their site of action.

  本发明公开了制备可生物裂解或可生物降解胶束组合物的组合物和方法，该组合物可携带和释放用于治疗或其他医疗用途的药物和其他活性剂。本发明还公开了制备可在受控条件下释放药物的可生物裂解环糊精胶束载体的方法。 本发明还公开了生物可裂解或生物可降解胶束组合物，这些组合物与生物识别分子耦合，用于将药物靶向输送到其作用部位。
• Cyclodextrin polymer compositions for use as drug carriers
  申请人：——

  公开号：US20010034333A1

  公开（公告）日：2001-10-25

  This invention discloses compositions of cyclodextrin polymers for carrying drugs and other active agents. Compositions are also disclosed of cyclodextrin polymer carriers that release drugs under controlled conditions. The invention also discloses compositions of cyclodextrin polymer carriers that are coupled to biorecognition molecules for targeting the delivery of drugs to their site of action. The advantages of the water-soluble cyclodextrin polymer carrier are: (1) Drugs can be used based on efficacy without solubility or conjugation requirements. (2) Drugs can be delivered as macromolecules and released within the cell. (3) Drugs can be targeted by coupling the carrier to biorecognition molecules. (4) Synthesis methods are independent of the drug to facilitate multiple drug therapies.

  本发明公开了用于携带药物和其他活性剂的环糊精聚合物组合物。本发明还公开了可在受控条件下释放药物的环糊精聚合物载体组合物。本发明还公开了环糊精聚合物载体的组合物，这些载体与生物识别分子结合，可将药物定向输送到其作用部位。 水溶性环糊精聚合物载体的优点是 (1) 可根据药效使用药物，无需溶解度或共轭要求。 (2) 可将药物作为大分子递送并在细胞内释放。 (3) 通过将载体与生物识别分子耦合，可实现药物的靶向性。 (4) 合成方法与药物无关，便于进行多种药物治疗。
• Sanecki, Przemyslaw; Rokaszewski, Edward, Canadian Journal of Chemistry, 1988, vol. 66, p. 3056 - 3059
  作者：Sanecki, Przemyslaw、Rokaszewski, Edward

  DOI：——

  日期：——
• Bhatt; Parekh; Parikh, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 1, p. 57 - 61
  作者：Bhatt、Parekh、Parikh、Parikh

  DOI：——

  日期：——