1-(2,2-Dibromo-1-methylcyclopropyl)-4-nitrobenzene | 301326-36-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,2-Dibromo-1-methylcyclopropyl)-4-nitrobenzene
• CAS: 301326-36-3
• 化学式: C₁₀H₉Br₂NO₂
• 分子量: 334.995
• InChiKey: ZQQPIDLGDLMCEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  三溴甲烷 、 1-isopropenyl-4-nitro-benzene 在 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 以85%的产率得到1-(2,2-Dibromo-1-methylcyclopropyl)-4-nitrobenzene
  参考文献：
  名称：

  Improved preparative route toward 3-arylcyclopropenes

  摘要：

  A convenient preparative protocol for the synthesis of various 3-arylcyclopropenes in a multigram, scale is disclosed. Optimization of the reaction conditions and isolation procedures allowed for significant improvement of the chemical yields of these strained products. The described protocol was used for efficient preparation of a series of 3-methyl-3-arylcyclopropenes possessing different substituents in the aromatic ring. The effect of substitution in the aryl group on the stability of 3-arylcyclopropenes, as well as the corresponding precursors, is discussed. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.06.087

文献信息

• Improved preparative route toward 3-arylcyclopropenes
  作者：William M. Sherrill、Ryan Kim、Michael Rubin

  DOI：10.1016/j.tet.2008.06.087

  日期：2008.9

  A convenient preparative protocol for the synthesis of various 3-arylcyclopropenes in a multigram, scale is disclosed. Optimization of the reaction conditions and isolation procedures allowed for significant improvement of the chemical yields of these strained products. The described protocol was used for efficient preparation of a series of 3-methyl-3-arylcyclopropenes possessing different substituents in the aromatic ring. The effect of substitution in the aryl group on the stability of 3-arylcyclopropenes, as well as the corresponding precursors, is discussed. (c) 2008 Elsevier Ltd. All rights reserved.