17-vinyl testosterone | 1235-98-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17-vinyl testosterone
• 英文别名: 17α-Vinylandrost-4-en-17β-ol-3-on；17-Vinyl-testosteron；(10R,13S,17R)-17-ethenyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
• CAS: 1235-98-9；4244-02-4
• 化学式: C₂₁H₃₀O₂
• 分子量: 314.468
• InChiKey: ILGPJZIKYMIGMU-AYUYWISESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  ethisterone 在 palladium, 5% on calcium carbonate, poisoned with lead 1-己烯 、 氢气 作用下， 以 甲醇 为溶剂， 40.0~60.0 ℃ 、172.37 kPa 条件下， 反应 5.5h， 以96.7%的产率得到17-vinyl testosterone
  参考文献：
  名称：

  [EN] STEROID SPIROLACTONIZATION
  [FR] SPIROLACTONISATION DE STEROIDES

  摘要：

  公开号：

  WO2004085458A3

文献信息

• "METHODS AND PRODUCTS FOR TREATMENT OF DISEASES"
  申请人：Bar-Or David

  公开号：US20070111972A1

  公开（公告）日：2007-05-17

  The present invention relates to the treatment of diseases and conditions with an effective amount of a steroid having those formulas given in the specification, or a pharmacologically-acceptable salt or ester thereof. The disease or conditions treatable according to the invention include angiogenic diseases and conditions of the eye, angiogenic diseases and conditions of the brain, inflammatory diseases and conditions of the eye, inflammatory diseases and conditions of the brain and neurodegenerative diseases.
• METHODS AND PRODUCTS FOR TREATMENT OF DISEASES
  申请人：Bar-Or David

  公开号：US20110171306A1

  公开（公告）日：2011-07-14

  The present invention relates to the treatment of diseases and conditions with an effective amount of a steroid having those formulas given in the specification, or a pharmacologically-acceptable salt or ester thereof. The disease or conditions treatable according to the invention include angiogenic diseases and conditions of the eye, angiogenic diseases and conditions of the brain, inflammatory diseases and conditions of the eye, inflammatory diseases and conditions of the brain and neurodegenerative diseases.
• [EN] STEROID SPIROLACTONIZATION<br/>[FR] SPIROLACTONISATION DE STEROIDES
  申请人：PHARMACIA CORP

  公开号：WO2004085458A3

  公开（公告）日：2006-03-16