2-(4-(2,2,2-trifluoroacetamido)phenyl)acetic acid | 105113-62-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-(2,2,2-trifluoroacetamido)phenyl)acetic acid
• 英文别名: {4-[(Trifluoroacetyl)amino]phenyl}acetic acid；2-[4-[(2,2,2-trifluoroacetyl)amino]phenyl]acetic acid
• CAS: 105113-62-0
• 化学式: C₁₀H₈F₃NO₃
• 分子量: 247.174
• InChiKey: PXOSUSANPOVCLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(4-(2,2,2-trifluoroacetamido)phenyl)acetic acid 在 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 phenyl 4-(trifluoroacetamido)phenylacetate
  参考文献：
  名称：

  Antibody catalysis approaching the activity of enzymes

  摘要：

  DOI：

  10.1021/ja00215a045
• 作为产物：
  描述：

  4'-(4''-carboxybutyramido)phenyl 4-(trifluoroacetamido)phenylacetate 在 antibody 50D₈ 水 作用下， 生成 2-(4-(2,2,2-trifluoroacetamido)phenyl)acetic acid
  参考文献：
  名称：

  Antibody catalysis approaching the activity of enzymes

  摘要：

  DOI：

  10.1021/ja00215a045

文献信息

• [EN] NOVEL LUMINESCENT LANTHANIDE CHELATE REPORTERS, BIOSPECIFIC BINDING REACTANTS LABELLED WITH NOVEL LUMINESCENT LANTHANIDE CHELATE REPORTERS AND THEIR USE<br/>[FR] NOUVEAUX RAPPORTEURS LUMINESCENTS DE CHÉLATES DE LANTHANIDES, RÉACTIFS DE LIAISON BIOSPÉCIFIQUES MARQUÉS AVEC DE NOUVEAUX RAPPORTEURS LUMINESCENTS DE CHÉLATES DE LANTHANIDES ET LEUR UTILISATION
  申请人：RADIOMETER TURKU OY

  公开号：WO2020260384A1

  公开（公告）日：2020-12-30

  The present invention relates to novel luminescent lanthanide chelate reporters which are formed from two to three separate lanthanide chelate moieties covalently conjugated to each other to act as an unique labelling reactant, and which can be attached to a biospecific reactant and used in various assays.

  本发明涉及一种新型的发光镧系螯合物报告物，它由两到三个独立的镧系螯合物基团共价结合在一起形成，作为一种独特的标记试剂，并且可以附着在生物特异性试剂上，并用于各种分析中。
• Amide substituted xanthine derivatives
  申请人：——

  公开号：US20040014766A1

  公开（公告）日：2004-01-22

  The present invention is a 1,3,8 substituted xanthine derivative of formula I 1 or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 and R 3 are as defined in the specification. Compounds of formula I and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.

  本发明是一种具有如下结构的1,3,8取代黄嘌呤衍生物（I1）或其药学上可接受的盐，其中R1、R2和R3如规范中定义。公式I的化合物及其药学上可接受的盐或前药显示出作为糖异生调节剂的活性。
• [EN] AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY<br/>[FR] DERIVES DE XANTHINE A SUBSTITUTION AMIDE A ACTIVITE DE MODULATION DE LA GLUCONEOGENESE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2003106459A1

  公开（公告）日：2003-12-24

  The present invention is a 1,3,8 substituted xanthine derivative of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2 and R3 are as defined in the specification. Compounds of formula (I) and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.

  本发明是一种式（I）的1,3,8取代黄嘌呤衍生物或其药用盐，其中R1、R2和R3如规范中所定义。式（I）化合物及其药用盐或前药显示为糖异生调节剂的活性。
• Polyaminated ligands and metal complexes thereof
  申请人：Guerbet S.A.

  公开号：US05712389A1

  公开（公告）日：1998-01-27

  Poly(amino acid) derivatives, which are chelating agents of paramagnetic metal ions, in which at least 3 of the donor nitrogen atoms carry identical or different substituents, of formula CH (R.sub.1) --X, in which X represents CO.sub.2 R.sub.a, CONR.sub.b R.sub.c or P(R.sub.d)O.sub.2 H and R.sub.a, R.sub.b and R.sub.c, which are identical or different, represent H or optionally hydroxylated (C.sub.1 -C.sub.8)alkyl, R.sub.d represents OH, (C.sub.1 -C.sub.8)alkyl or (C.sub.1 -C.sub.8)alkoxy and R.sub.1 represents a hydrophilic group with a molecular weight greater than 200 containing at least 3 oxygen atoms, with the proviso that at least 3 of the X groups are optionally salified acid functional groups.

  聚（氨基酸）衍生物，是顺磁金属离子的螯合剂，其中至少有3个供体氮原子携带相同或不同的取代基，其化学式为CH（R.sub.1）--X，其中X代表CO.sub.2R.sub.a，CONR.sub.bR.sub.c或P(R.sub.d)O.sub.2H，而R.sub.a、R.sub.b和R.sub.c是相同或不同的，代表H或可选择羟基化的（C.sub.1-C.sub.8）烷基，R.sub.d代表OH，（C.sub.1-C.sub.8）烷基或（C.sub.1-C.sub.8）烷氧基，R.sub.1代表具有分子量大于200的至少3个氧原子的亲水基团，但至少3个X基团是可选择盐化的酸功能基团。
• [EN] LUMINESCENT LANTHANIDE CHELATES AND THEIR USE<br/>[FR] CHÉLATES DE LANTHANIDES LUMINESCENTS ET LEUR UTILISATION
  申请人：RADIOMETER TURKU OY

  公开号：WO2019179798A1

  公开（公告）日：2019-09-26

  The present application discloses a lanthanide chelate of formula (I) or a salt thereof, wherein at least one of Ch1 and Ch2 is an amide that forms a coordinate bond with the lanthanide. The application also discloses a detection agent comprising a biospecific binding reactant conjugated to the compound of formula (I). Disclosed are also methods of labelling a biospecific binding reactant as well as methods of detection an analyte therewith. Further, a solid support material conjugated with the compound of formula (I) is disclosed.

  本申请公开了一种配方(I)的镧系螯合物或其盐，其中Ch1和Ch2中至少有一个是与镧系元素形成配位键的酰胺。该申请还公开了一种检测试剂，其包括与配方(I)化合物结合的生物特异性结合试剂。还公开了一种标记生物特异性结合试剂的方法，以及用其检测分析物的方法。此外，还公开了与配方(I)化合物结合的固体支持材料。