(2S,6R)-1,7,8,9,10,10-Hexachloro-4-oxa-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,6R)-1,7,8,9,10,10-Hexachloro-4-oxa-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione
• 英文别名: (2R,6S)-1,7,8,9,10,10-hexachloro-4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
• 化学式: C₉H₂Cl₆O₃
• 分子量: 370.831
• InChiKey: FLBJFXNAEMSXGL-BDCSLDPFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2S,6R)-1,7,8,9,10,10-Hexachloro-4-oxa-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione 、 6-氨基己酸 在 三乙胺 作用下， 以 甲苯 为溶剂， 反应 8.0h， 以99%的产率得到
  参考文献：
  名称：

  Fiber Optic Biosensor for Cyclodiene Insecticides

  摘要：

  Chlorendic caproic acid (CCA) was used to synthesize hexachlorocyclopentadienefluorescein (FL) and bovine serum albumin (BSA) conjugates. Anti-CCA antibodies (CCA-Abs), which were raised against BSA-CCA and immobilized on quartz fibers, bound FL-CCA selectively and reversibly. Fluorescence generated by evanescent excitation of the bound FL-CCA was used to monitor the binding event. The affinity of CCA-Abs for FL-CCA (K-D = 1.9 nM) was calculated from the time courses of association and dissociation of FL-CCA. The cyclodiene insecticides chlordane, heptachlor, dieldrin, endrin, aldrin, and endosulfan competed with FL-CCA for binding to CCA-Abs and reduced fluorescence in a concentration-dependent manner with the following rank order: chlordane > heptachlor > dieldrin > aldrin > endosulfan. This fiber optic fluoroimmunosensor detects cyclodiene insecticides at the ppb level, has low cross-reactivity with gamma-hexachlorocyclohexane, and does not detect (p,p'-dichlorodiphenyl)trichloroethane (DDT).

  DOI：

  10.1021/jf9701190

文献信息

• Inhibition and Dispersion of Bacterial Biofilms with Benzimidazole Derivatives
  申请人：Melander Christian

  公开号：US20120171129A1

  公开（公告）日：2012-07-05

  Disclosure is provided for benzimidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions including these compounds, devices including these compounds, and methods of using the same.

  本发明提供一种苯并咪唑衍生物化合物，可预防、去除和/或抑制生物膜的形成，包括这些化合物的组合物、包括这些化合物的设备，以及使用它们的方法。
• Ivanov, E. I.; Polishchuk, A. A.; Terent'ev, P. B., Journal of Organic Chemistry USSR (English Translation), 1991, vol. 27, # 1.2, p. 122 - 124
  作者：Ivanov, E. I.、Polishchuk, A. A.、Terent'ev, P. B.、Salakhov, F. M.、Salakhov, M. S.

  DOI：——

  日期：——
• US9221765B2
  申请人：——

  公开号：US9221765B2

  公开（公告）日：2015-12-29