2,4,5-trimethoxy-benzenesulfonyl chloride | 85477-01-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4,5-trimethoxy-benzenesulfonyl chloride
• 英文别名: 2,4,5-Trimethoxy-benzolsulfonylchlorid；3,4,6-trimethoxy benzene sulfonyl chloride；2,4,5-trimethoxy benzenesulfonyl chloride；2,4,5-Trimethoxybenzene-1-sulfonyl chloride；2,4,5-trimethoxybenzenesulfonyl chloride
• CAS: 85477-01-6
• 化学式: C₉H₁₁ClO₅S
• 分子量: 266.702
• InChiKey: LSFOYENWQJZHKY-UHFFFAOYSA-N

物化性质

• 沸点：
  400.1±45.0 °C(Predicted)
• 密度：
  1.346±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  70.2
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 储存条件：
  2-8°C

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 2,4,5-trimethoxy-benzenesulfonyl chloride
  参考文献：
  名称：

  Certain Derivatives of the Ethers of Hydroxyhydroquinone

  摘要：

  DOI：

  10.1021/ja01870a047

文献信息

• 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle
  申请人：Sekiguchi Yoshinori

  公开号：US20080318923A1

  公开（公告）日：2008-12-25

  It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. As the results of intensive studies, a novel 1,3-dihydro-2H-indol-2-one compound and a pyrrolidin-2-one compound fused with a heteroaromatic ring, which are highly selective antagonists of arginine-vasopressin V1b receptor, have high metabolic stabilities and show favorable brain penetration and high plasma concentrations, are found, thereby achieving the above objective.

  旨在提供一种对与精氨酸加压素V1b受体相关的病理状况具有疗效的药物。更具体地说，旨在提供一种对抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、消化系统疾病、药物成瘾、癫痫、脑梗死、脑缺血、脑水肿、头部损伤、炎症、免疫疾病、脱发等具有治疗或预防作用的药物。经过深入研究，发现了一种新颖的1,3-二氢-2H-吲哚-2-酮化合物和与杂芳环融合的吡咯烷-2-酮化合物，它们是高度选择性的精氨酸加压素V1b受体拮抗剂，具有高代谢稳定性，表现出有利的血脑屏障穿透和高血浆浓度，从而实现了上述目标。
• N-substituted 2,4-dialkoxy benzenesulfonamides and pharmaceutical
  申请人：Choay S.A.

  公开号：US04714700A1

  公开（公告）日：1987-12-22

  The invention relates to new N-substituted benzenesulfonamides, the process for their preparation and their use. The compounds according to the invention correspond to the general formula (I): ##STR1## in which: n and m have values from 0 to 4; R.sub.3 and R.sub.4 represent in particular a lower alkyl radical; R.sub.1 and R.sub.2 represent in particular hydrogen atoms, linear or branched alkyl groups having from 1 to 4 carbon atoms; R.sub.5 represents particularly a hydrogen atom, a halogen, the NO.sub.2, NH.sub.2, or CF.sub.3 group; R.sub.6 and R.sub.7 represent in particular a hydrogen atom, an alkyl radical of 1 to 6 carbon atoms. The invention is useful in the preparation of tranquilizing or anxiolytic medicines.

  该发明涉及新的N-取代苯磺酰胺，其制备过程及其用途。根据该发明的化合物对应于一般式(I)：##STR1## 其中：n和m的值为0到4；R.sub.3和R.sub.4特别表示较低的烷基基团；R.sub.1和R.sub.2特别表示氢原子，具有1到4个碳原子的直链或支链烷基基团；R.sub.5特别表示氢原子，卤素，NO.sub.2，NH.sub.2或CF.sub.3基团；R.sub.6和R.sub.7特别表示1到6个碳原子的烷基基团。该发明在制备镇静或抗焦虑药物方面是有用的。
• [EN] SULFONAMIDES<br/>[FR] SULFONAMIDES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2002089792A1

  公开（公告）日：2002-11-14

  The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.

  本发明涉及磺酰胺类化合物、含有它们的药物组合物以及它们作为尿泰松Ⅱ拮抗剂的用途。
• Sulfonamides
  申请人：——

  公开号：US20040152906A1

  公开（公告）日：2004-08-05

  The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.

  本发明涉及磺酰胺、含有它们的药物组合物，以及它们作为尿嘧啶II拮抗剂的用途。
• 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle
  申请人：Taisho Pharmaceutical Co., Ltd.

  公开号：US08030499B2

  公开（公告）日：2011-10-04

  It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. As the results of intensive studies, a novel 1,3-dihydro-2H-indol-2-one compound and a pyrrolidin-2-one compound fused with a heteroaromatic ring, which are highly selective antagonists of arginine-vasopressin V1b receptor, have high metabolic stabilities and show favorable brain penetration and high plasma concentrations, are found, thereby achieving the above objective.

  本发明旨在提供一种对精氨酸加压素V1b受体相关的病理状况有效的药物。更具体地说，本发明旨在提供一种对抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、饮食失调、高血压、消化系统疾病、药物成瘾、癫痫、脑梗死、脑缺血、脑水肿、头部损伤、炎症、免疫性疾病、脱发等具有治疗或预防作用的药物。经过密集研究，发现了一种新型的1,3-二氢吲哚-2-酮化合物和一种与杂环芳香环融合的吡咯烷-2-酮化合物，它们是高度选择性的精氨酸加压素V1b受体拮抗剂，具有高代谢稳定性、良好的脑穿透性和高血浆浓度，从而实现了上述目标。