5-benzyl-3-methylcyclopent-2-enone | 439901-25-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-benzyl-3-methylcyclopent-2-enone
• 英文别名: 5-Benzyl-3-methylcyclopent-2-en-1-one
• CAS: 439901-25-4
• 化学式: C₁₃H₁₄O
• 分子量: 186.254
• InChiKey: NPJQJEACACCZCF-UHFFFAOYSA-N

物化性质

• 沸点：
  306.9±12.0 °C(Predicted)
• 密度：
  1.065±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  manganese triacetate 、 5-benzyl-3-methylcyclopent-2-enone 以 苯 为溶剂， 反应 18.0h， 以51%的产率得到(+/-)-5-acetoxy-5-benzyl-3-methyl-2-cyclopenten-1-one
  参考文献：
  名称：

  乙酸锰（III）氧化环状α，β-不饱和酮上的α'-取代基

  摘要：

  描述了用乙酸锰（III）选择性氧化各种2-环戊烯酮，2-环己烯酮和芳族酮衍生物上的叔α'-位置。

  DOI：

  10.1016/s0040-4020(03)01094-9
• 作为产物：
  描述：

  3-甲基-2-环戊烯-1-酮 、 溴甲苯 在 manganese triacetate 作用下， 以 苯 为溶剂， 反应 9.0h， 以65%的产率得到5-benzyl-3-methylcyclopent-2-enone
  参考文献：
  名称：

  Mn(III) acetate-mediated regioselective benzylation of various α,β-unsaturated and β-alkoxy-α,β-unsaturated ketones

  摘要：

  We describe herein the results of manganese(III) acetate mediated alpha'-benzylation of various a,p-unsaturated and beta-alkoxy-alpha,beta-unsaturated ketones in moderate yields. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.08.001

文献信息

• The first enzymatic resolution of quaternary α′-acetoxy α,β-unsaturated cyclohexenones and cyclopentenones
  作者：Cihangir Tanyeli、Fazilet Devrim Özdemirhan、Çiğdem İyigün

  DOI：10.1016/j.tetasy.2005.11.016

  日期：2005.12

  The enantio selective resolution of various quaternary alpha'-acetoxy alpha,beta-unsaturated cyclohexenones and cyclopentenones was performed with the commercially available enzyme CCL in pH = 8.0 phosphate buffer. Various parameters that would affect the enantioselectivities were tested and the best enzymatic resolution conditions were found to afford the enantiomerically enriched quaternary acetoxylated substrates with high ee varying between 36% and 99%. (c) 2005 Elsevier Ltd. All rights reserved.
• Manganese(III) acetate based oxidation of substituted α′-position on cyclic α,β-unsaturated ketones
  作者：Cihangir Tanyeli、Çigdem Iyigün

  DOI：10.1016/s0040-4020(03)01094-9

  日期：2003.9

  Selective oxidation of the tertiary α′-position on various 2-cyclopentenone, 2-cyclohexenone and aromatic ketone derivatives with manganese(III) acetate is described.

  描述了用乙酸锰（III）选择性氧化各种2-环戊烯酮，2-环己烯酮和芳族酮衍生物上的叔α'-位置。
• Mn(III) acetate-mediated regioselective benzylation of various α,β-unsaturated and β-alkoxy-α,β-unsaturated ketones
  作者：Cihangir Tanyeli、Devrim Özdemirhan

  DOI：10.1016/j.tetlet.2003.08.001

  日期：2003.9

  We describe herein the results of manganese(III) acetate mediated alpha'-benzylation of various a,p-unsaturated and beta-alkoxy-alpha,beta-unsaturated ketones in moderate yields. (C) 2003 Elsevier Ltd. All rights reserved.